Metagenomic analysis of a throat swab sample collected in China on a patient infected with Varicella Zoster Virus

Abstract Varicella Zoster Virus (VZV) is endemic worldwide, causing varicella in children and zoster upon reactivation in adults. This study concerned a metagenomic analysis of a throat swab sample collected in China, on a young patient suffering from Systemic Lupus Erythematosus (SLE) and diagnosed...

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Autores principales: Hong Guo, Pierre Rivailler, Jiangxia Wang, Huanyu Wang, Wenbo Xu, Songtao Xu, Hongmei Xu, Ruiping Hu
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ad877ef3d7204a87910aad26e4b650ac
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spelling oai:doaj.org-article:ad877ef3d7204a87910aad26e4b650ac2021-12-02T16:14:46ZMetagenomic analysis of a throat swab sample collected in China on a patient infected with Varicella Zoster Virus10.1038/s41598-021-93230-82045-2322https://doaj.org/article/ad877ef3d7204a87910aad26e4b650ac2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93230-8https://doaj.org/toc/2045-2322Abstract Varicella Zoster Virus (VZV) is endemic worldwide, causing varicella in children and zoster upon reactivation in adults. This study concerned a metagenomic analysis of a throat swab sample collected in China, on a young patient suffering from Systemic Lupus Erythematosus (SLE) and diagnosed with varicella. The complete genome sequence of a VZV strain of clade 2 has been generated. Clade 2 strains are the most prevalent in Asian countries. A comparison of 223 VZV genomes identified 77 clade specific markers, 20 of them specific to clade 2. The metagenomic analysis also identified sequences covering most of the genome of the bacteria Schaalia odontolytica also known as Actinomyces odontolyticus. VZV infection and bacterial infection in the context of SLE is further discussed. Even though the patient presented only mild symptoms, this study is a reminder that vaccination against VZV is critical to avoid severe complications like bacterial superinfection or even death in the case of immunodeficiency.Hong GuoPierre RivaillerJiangxia WangHuanyu WangWenbo XuSongtao XuHongmei XuRuiping HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Hong Guo
Pierre Rivailler
Jiangxia Wang
Huanyu Wang
Wenbo Xu
Songtao Xu
Hongmei Xu
Ruiping Hu
Metagenomic analysis of a throat swab sample collected in China on a patient infected with Varicella Zoster Virus
description Abstract Varicella Zoster Virus (VZV) is endemic worldwide, causing varicella in children and zoster upon reactivation in adults. This study concerned a metagenomic analysis of a throat swab sample collected in China, on a young patient suffering from Systemic Lupus Erythematosus (SLE) and diagnosed with varicella. The complete genome sequence of a VZV strain of clade 2 has been generated. Clade 2 strains are the most prevalent in Asian countries. A comparison of 223 VZV genomes identified 77 clade specific markers, 20 of them specific to clade 2. The metagenomic analysis also identified sequences covering most of the genome of the bacteria Schaalia odontolytica also known as Actinomyces odontolyticus. VZV infection and bacterial infection in the context of SLE is further discussed. Even though the patient presented only mild symptoms, this study is a reminder that vaccination against VZV is critical to avoid severe complications like bacterial superinfection or even death in the case of immunodeficiency.
format article
author Hong Guo
Pierre Rivailler
Jiangxia Wang
Huanyu Wang
Wenbo Xu
Songtao Xu
Hongmei Xu
Ruiping Hu
author_facet Hong Guo
Pierre Rivailler
Jiangxia Wang
Huanyu Wang
Wenbo Xu
Songtao Xu
Hongmei Xu
Ruiping Hu
author_sort Hong Guo
title Metagenomic analysis of a throat swab sample collected in China on a patient infected with Varicella Zoster Virus
title_short Metagenomic analysis of a throat swab sample collected in China on a patient infected with Varicella Zoster Virus
title_full Metagenomic analysis of a throat swab sample collected in China on a patient infected with Varicella Zoster Virus
title_fullStr Metagenomic analysis of a throat swab sample collected in China on a patient infected with Varicella Zoster Virus
title_full_unstemmed Metagenomic analysis of a throat swab sample collected in China on a patient infected with Varicella Zoster Virus
title_sort metagenomic analysis of a throat swab sample collected in china on a patient infected with varicella zoster virus
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ad877ef3d7204a87910aad26e4b650ac
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