Multinucleation associated DNA damage blocks proliferation in p53-compromised cells

Hart et al. track newborn single cells by live microscopy after inducing a variety of nuclear atypia by CENP-E inhibitor treatment. They find that that multinucleation, unlike other forms of nuclear atypia, blocks proliferation independently of p53 and is associated with persistent 53BP1 DNA damage...

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Autores principales:	Madeleine Hart, Sophie D. Adams, Viji M. Draviam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ad8b367f74aa42028c6ccf97367274c0
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spelling	oai:doaj.org-article:ad8b367f74aa42028c6ccf97367274c02021-12-02T18:15:35ZMultinucleation associated DNA damage blocks proliferation in p53-compromised cells10.1038/s42003-021-01979-52399-3642https://doaj.org/article/ad8b367f74aa42028c6ccf97367274c02021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01979-5https://doaj.org/toc/2399-3642Hart et al. track newborn single cells by live microscopy after inducing a variety of nuclear atypia by CENP-E inhibitor treatment. They find that that multinucleation, unlike other forms of nuclear atypia, blocks proliferation independently of p53 and is associated with persistent 53BP1 DNA damage foci, thus providing insights into the consequences of multinucleation, often observed in disease states.Madeleine HartSophie D. AdamsViji M. DraviamNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Madeleine Hart Sophie D. Adams Viji M. Draviam Multinucleation associated DNA damage blocks proliferation in p53-compromised cells
description	Hart et al. track newborn single cells by live microscopy after inducing a variety of nuclear atypia by CENP-E inhibitor treatment. They find that that multinucleation, unlike other forms of nuclear atypia, blocks proliferation independently of p53 and is associated with persistent 53BP1 DNA damage foci, thus providing insights into the consequences of multinucleation, often observed in disease states.
format	article
author	Madeleine Hart Sophie D. Adams Viji M. Draviam
author_facet	Madeleine Hart Sophie D. Adams Viji M. Draviam
author_sort	Madeleine Hart
title	Multinucleation associated DNA damage blocks proliferation in p53-compromised cells
title_short	Multinucleation associated DNA damage blocks proliferation in p53-compromised cells
title_full	Multinucleation associated DNA damage blocks proliferation in p53-compromised cells
title_fullStr	Multinucleation associated DNA damage blocks proliferation in p53-compromised cells
title_full_unstemmed	Multinucleation associated DNA damage blocks proliferation in p53-compromised cells
title_sort	multinucleation associated dna damage blocks proliferation in p53-compromised cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad8b367f74aa42028c6ccf97367274c0
work_keys_str_mv	AT madeleinehart multinucleationassociateddnadamageblocksproliferationinp53compromisedcells AT sophiedadams multinucleationassociateddnadamageblocksproliferationinp53compromisedcells AT vijimdraviam multinucleationassociateddnadamageblocksproliferationinp53compromisedcells
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Multinucleation associated DNA damage blocks proliferation in p53-compromised cells

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