Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study

Abstract Serum sodium concentration within the normal range could act as an indicator of age-related changes such as decrease in muscle strength and impairment of capillary function. Since endothelial injury stimulates endothelial repair by enhancing CD34-positive cell production, the level of serum...

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Autores principales:	Yuji Shimizu, Hirotomo Yamanashi, Shoichi Fukui, Shin-Ya Kawashiri, Yasuhiro Nagata, Takahiro Maeda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad8b58a0b22e4b7d9a69aec9ad294e3c
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spelling	oai:doaj.org-article:ad8b58a0b22e4b7d9a69aec9ad294e3c2021-12-02T15:23:08ZAssociation between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study10.1038/s41598-020-80163-x2045-2322https://doaj.org/article/ad8b58a0b22e4b7d9a69aec9ad294e3c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80163-xhttps://doaj.org/toc/2045-2322Abstract Serum sodium concentration within the normal range could act as an indicator of age-related changes such as decrease in muscle strength and impairment of capillary function. Since endothelial injury stimulates endothelial repair by enhancing CD34-positive cell production, the level of serum sodium may be inversely associated with that of circulating CD34-positive cells, thus indicating the degree of age-related endothelial injury. We conducted a cross-sectional study of 246 elderly Japanese men aged 60–69 years. Subjects were stratified by hypertension status because hypertension should act as a strong confounding factor for the analyses performed in this study. Serum sodium concentration was positively associated with handgrip strength in non-hypertensive subjects [standardized parameter estimate (β) = 0.29; p = 0.003], but not for hypertensive subjects (β = 0.01; p = 0.878), while it was inversely associated with circulating CD34-positive cell levels in non-hypertensive subjects [simple correlation coefficient (r) = − 0.28; p = 0.002] but not for hypertensive subjects (r = − 0.07; p = 0.454). For non-hypertensive elderly subjects, serum sodium concentration within the normal range is positively associated with handgrip strength and inversely associated with CD34-positive cells, thus partly indicating the degree of age-related endothelium injury. These associations could prove to be an efficient tool for clarifying the background mechanism governing the decrease in age-related muscle strength.Yuji ShimizuHirotomo YamanashiShoichi FukuiShin-Ya KawashiriYasuhiro NagataTakahiro MaedaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuji Shimizu Hirotomo Yamanashi Shoichi Fukui Shin-Ya Kawashiri Yasuhiro Nagata Takahiro Maeda Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study
description	Abstract Serum sodium concentration within the normal range could act as an indicator of age-related changes such as decrease in muscle strength and impairment of capillary function. Since endothelial injury stimulates endothelial repair by enhancing CD34-positive cell production, the level of serum sodium may be inversely associated with that of circulating CD34-positive cells, thus indicating the degree of age-related endothelial injury. We conducted a cross-sectional study of 246 elderly Japanese men aged 60–69 years. Subjects were stratified by hypertension status because hypertension should act as a strong confounding factor for the analyses performed in this study. Serum sodium concentration was positively associated with handgrip strength in non-hypertensive subjects [standardized parameter estimate (β) = 0.29; p = 0.003], but not for hypertensive subjects (β = 0.01; p = 0.878), while it was inversely associated with circulating CD34-positive cell levels in non-hypertensive subjects [simple correlation coefficient (r) = − 0.28; p = 0.002] but not for hypertensive subjects (r = − 0.07; p = 0.454). For non-hypertensive elderly subjects, serum sodium concentration within the normal range is positively associated with handgrip strength and inversely associated with CD34-positive cells, thus partly indicating the degree of age-related endothelium injury. These associations could prove to be an efficient tool for clarifying the background mechanism governing the decrease in age-related muscle strength.
format	article
author	Yuji Shimizu Hirotomo Yamanashi Shoichi Fukui Shin-Ya Kawashiri Yasuhiro Nagata Takahiro Maeda
author_facet	Yuji Shimizu Hirotomo Yamanashi Shoichi Fukui Shin-Ya Kawashiri Yasuhiro Nagata Takahiro Maeda
author_sort	Yuji Shimizu
title	Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study
title_short	Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study
title_full	Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study
title_fullStr	Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study
title_full_unstemmed	Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study
title_sort	association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad8b58a0b22e4b7d9a69aec9ad294e3c
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Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study

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