Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis

Microsomal glutathione S-transferase 2 (MGST2) produces leukotriene C4, an intracrine mediator of cell death. Structural, biochemical and computational analyses of human MGST2 suggest a mechanism employed by the enzyme to restrict catalysis to only one active site within the MGST2 trimer.

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Autores principales:	Madhuranayaki Thulasingam, Laura Orellana, Emmanuel Nji, Shabbir Ahmad, Agnes Rinaldo-Matthis, Jesper Z. Haeggström
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad8bc33695d24df2a94e100658df694b
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spelling	oai:doaj.org-article:ad8bc33695d24df2a94e100658df694b2021-12-02T16:30:42ZCrystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis10.1038/s41467-021-21924-82041-1723https://doaj.org/article/ad8bc33695d24df2a94e100658df694b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21924-8https://doaj.org/toc/2041-1723Microsomal glutathione S-transferase 2 (MGST2) produces leukotriene C4, an intracrine mediator of cell death. Structural, biochemical and computational analyses of human MGST2 suggest a mechanism employed by the enzyme to restrict catalysis to only one active site within the MGST2 trimer.Madhuranayaki ThulasingamLaura OrellanaEmmanuel NjiShabbir AhmadAgnes Rinaldo-MatthisJesper Z. HaeggströmNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Madhuranayaki Thulasingam Laura Orellana Emmanuel Nji Shabbir Ahmad Agnes Rinaldo-Matthis Jesper Z. Haeggström Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
description	Microsomal glutathione S-transferase 2 (MGST2) produces leukotriene C4, an intracrine mediator of cell death. Structural, biochemical and computational analyses of human MGST2 suggest a mechanism employed by the enzyme to restrict catalysis to only one active site within the MGST2 trimer.
format	article
author	Madhuranayaki Thulasingam Laura Orellana Emmanuel Nji Shabbir Ahmad Agnes Rinaldo-Matthis Jesper Z. Haeggström
author_facet	Madhuranayaki Thulasingam Laura Orellana Emmanuel Nji Shabbir Ahmad Agnes Rinaldo-Matthis Jesper Z. Haeggström
author_sort	Madhuranayaki Thulasingam
title	Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
title_short	Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
title_full	Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
title_fullStr	Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
title_full_unstemmed	Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
title_sort	crystal structures of human mgst2 reveal synchronized conformational changes regulating catalysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad8bc33695d24df2a94e100658df694b
work_keys_str_mv	AT madhuranayakithulasingam crystalstructuresofhumanmgst2revealsynchronizedconformationalchangesregulatingcatalysis AT lauraorellana crystalstructuresofhumanmgst2revealsynchronizedconformationalchangesregulatingcatalysis AT emmanuelnji crystalstructuresofhumanmgst2revealsynchronizedconformationalchangesregulatingcatalysis AT shabbirahmad crystalstructuresofhumanmgst2revealsynchronizedconformationalchangesregulatingcatalysis AT agnesrinaldomatthis crystalstructuresofhumanmgst2revealsynchronizedconformationalchangesregulatingcatalysis AT jesperzhaeggstrom crystalstructuresofhumanmgst2revealsynchronizedconformationalchangesregulatingcatalysis
_version_	1718383950590640128

Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis

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