Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes

Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes

Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malar...

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Auteurs principaux: Marek Cyrklaff, Sirikamol Srismith, Britta Nyboer, Kvetoslava Burda, Angelika Hoffmann, Felix Lasitschka, Sophie Adjalley, Cyrille Bisseye, Jacques Simpore, Ann-Kristin Mueller, Cecilia P. Sanchez, Friedrich Frischknecht, Michael Lanzer
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Q
Accès en ligne:https://doaj.org/article/ad8f730d0ece4e689ceb8d952125110c
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spelling oai:doaj.org-article:ad8f730d0ece4e689ceb8d952125110c2021-12-02T14:39:13ZOxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes10.1038/ncomms134012041-1723https://doaj.org/article/ad8f730d0ece4e689ceb8d952125110c2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13401https://doaj.org/toc/2041-1723Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malaria in mice.Marek CyrklaffSirikamol SrismithBritta NyboerKvetoslava BurdaAngelika HoffmannFelix LasitschkaSophie AdjalleyCyrille BisseyeJacques SimporeAnn-Kristin MuellerCecilia P. SanchezFriedrich FrischknechtMichael LanzerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marek Cyrklaff
Sirikamol Srismith
Britta Nyboer
Kvetoslava Burda
Angelika Hoffmann
Felix Lasitschka
Sophie Adjalley
Cyrille Bisseye
Jacques Simpore
Ann-Kristin Mueller
Cecilia P. Sanchez
Friedrich Frischknecht
Michael Lanzer
Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
description Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malaria in mice.
format article
author Marek Cyrklaff
Sirikamol Srismith
Britta Nyboer
Kvetoslava Burda
Angelika Hoffmann
Felix Lasitschka
Sophie Adjalley
Cyrille Bisseye
Jacques Simpore
Ann-Kristin Mueller
Cecilia P. Sanchez
Friedrich Frischknecht
Michael Lanzer
author_facet Marek Cyrklaff
Sirikamol Srismith
Britta Nyboer
Kvetoslava Burda
Angelika Hoffmann
Felix Lasitschka
Sophie Adjalley
Cyrille Bisseye
Jacques Simpore
Ann-Kristin Mueller
Cecilia P. Sanchez
Friedrich Frischknecht
Michael Lanzer
author_sort Marek Cyrklaff
title Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
title_short Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
title_full Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
title_fullStr Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
title_full_unstemmed Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
title_sort oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/ad8f730d0ece4e689ceb8d952125110c
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AT michaellanzer oxidativeinsultcaninducemalariaprotectivetraitofsickleandfetalerythrocytes
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