Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes

Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malar...

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Autores principales:	Marek Cyrklaff, Sirikamol Srismith, Britta Nyboer, Kvetoslava Burda, Angelika Hoffmann, Felix Lasitschka, Sophie Adjalley, Cyrille Bisseye, Jacques Simpore, Ann-Kristin Mueller, Cecilia P. Sanchez, Friedrich Frischknecht, Michael Lanzer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad8f730d0ece4e689ceb8d952125110c
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spelling	oai:doaj.org-article:ad8f730d0ece4e689ceb8d952125110c2021-12-02T14:39:13ZOxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes10.1038/ncomms134012041-1723https://doaj.org/article/ad8f730d0ece4e689ceb8d952125110c2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13401https://doaj.org/toc/2041-1723Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malaria in mice.Marek CyrklaffSirikamol SrismithBritta NyboerKvetoslava BurdaAngelika HoffmannFelix LasitschkaSophie AdjalleyCyrille BisseyeJacques SimporeAnn-Kristin MuellerCecilia P. SanchezFriedrich FrischknechtMichael LanzerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marek Cyrklaff Sirikamol Srismith Britta Nyboer Kvetoslava Burda Angelika Hoffmann Felix Lasitschka Sophie Adjalley Cyrille Bisseye Jacques Simpore Ann-Kristin Mueller Cecilia P. Sanchez Friedrich Frischknecht Michael Lanzer Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
description	Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malaria in mice.
format	article
author	Marek Cyrklaff Sirikamol Srismith Britta Nyboer Kvetoslava Burda Angelika Hoffmann Felix Lasitschka Sophie Adjalley Cyrille Bisseye Jacques Simpore Ann-Kristin Mueller Cecilia P. Sanchez Friedrich Frischknecht Michael Lanzer
author_facet	Marek Cyrklaff Sirikamol Srismith Britta Nyboer Kvetoslava Burda Angelika Hoffmann Felix Lasitschka Sophie Adjalley Cyrille Bisseye Jacques Simpore Ann-Kristin Mueller Cecilia P. Sanchez Friedrich Frischknecht Michael Lanzer
author_sort	Marek Cyrklaff
title	Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
title_short	Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
title_full	Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
title_fullStr	Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
title_full_unstemmed	Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
title_sort	oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ad8f730d0ece4e689ceb8d952125110c
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Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes

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