Glomerulonephritis in Two Patients with SpA Treated with TNF-α Blockers and a Review of the Literature
Constantina A Bounia,1 Eftichia N Theodoropoulou,1 Stamatic-Nick C Liossis1,2 1Division of Rheumatology, Patras University Hospital, Patras, Greece; 2Department of Internal Medicine, University of Patras Medical School, Patras, GreeceCorrespondence: Stamatic-Nick C LiossisDiv. of Rheumatology, Patra...
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Dove Medical Press
2021
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oai:doaj.org-article:ad9096b4f0684a9b98876462563f1d882021-12-02T13:34:19ZGlomerulonephritis in Two Patients with SpA Treated with TNF-α Blockers and a Review of the Literature1177-5491https://doaj.org/article/ad9096b4f0684a9b98876462563f1d882021-03-01T00:00:00Zhttps://www.dovepress.com/glomerulonephritis-in-two-patients-with-spa-treated-with-tnf-alpha-blo-peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Constantina A Bounia,1 Eftichia N Theodoropoulou,1 Stamatic-Nick C Liossis1,2 1Division of Rheumatology, Patras University Hospital, Patras, Greece; 2Department of Internal Medicine, University of Patras Medical School, Patras, GreeceCorrespondence: Stamatic-Nick C LiossisDiv. of Rheumatology, Patras University Hospital, GR 26500, Rion, Patras, GreeceTel +30 2613 603 693Fax +30 2610 993 982Email snliossis@med.upatras.grAbstract: Renal failure or acute/chronic kidney damage may present as a clinical manifestation of rheumatic diseases. In addition treatment with DMARDs or biologic drugs may induce nephrotoxicity. In this case-based review, we present two patients with SpA under anti-TNF-α treatment admitted to our hospital because of renal failure and proteinuria. We review previously published yet isolated cases of TNF-α blocker-induced glomerular disease in patients with SpA. Renal manifestations are occasionally seen in patients with ankylosing spondylitis and psoriatic arthritis with IgA nephropathy being the most common of them. Anti-TNF-α agents although reportedly used for the treatment of glomerular nephropathy as a disease manifestation, they have been considered responsible for provoking renal damage in some cases. A diagnostic approach for patients with SpA treated with anti-TNF-α agents presenting with renal manifestations is proposed herein.Keywords: spondylarthritides, glomerular disease, proteinuria, kidney biopsy, anti-TNF-alpha agentsBounia CATheodoropoulou ENLiossis SNCDove Medical Pressarticlespondylarthritidesglomerular diseaseproteinuriakidney biopsyanti-tnf-alpha agentsMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 15, Pp 61-66 (2021) |
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spondylarthritides glomerular disease proteinuria kidney biopsy anti-tnf-alpha agents Medicine (General) R5-920 |
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spondylarthritides glomerular disease proteinuria kidney biopsy anti-tnf-alpha agents Medicine (General) R5-920 Bounia CA Theodoropoulou EN Liossis SNC Glomerulonephritis in Two Patients with SpA Treated with TNF-α Blockers and a Review of the Literature |
| description |
Constantina A Bounia,1 Eftichia N Theodoropoulou,1 Stamatic-Nick C Liossis1,2 1Division of Rheumatology, Patras University Hospital, Patras, Greece; 2Department of Internal Medicine, University of Patras Medical School, Patras, GreeceCorrespondence: Stamatic-Nick C LiossisDiv. of Rheumatology, Patras University Hospital, GR 26500, Rion, Patras, GreeceTel +30 2613 603 693Fax +30 2610 993 982Email snliossis@med.upatras.grAbstract: Renal failure or acute/chronic kidney damage may present as a clinical manifestation of rheumatic diseases. In addition treatment with DMARDs or biologic drugs may induce nephrotoxicity. In this case-based review, we present two patients with SpA under anti-TNF-α treatment admitted to our hospital because of renal failure and proteinuria. We review previously published yet isolated cases of TNF-α blocker-induced glomerular disease in patients with SpA. Renal manifestations are occasionally seen in patients with ankylosing spondylitis and psoriatic arthritis with IgA nephropathy being the most common of them. Anti-TNF-α agents although reportedly used for the treatment of glomerular nephropathy as a disease manifestation, they have been considered responsible for provoking renal damage in some cases. A diagnostic approach for patients with SpA treated with anti-TNF-α agents presenting with renal manifestations is proposed herein.Keywords: spondylarthritides, glomerular disease, proteinuria, kidney biopsy, anti-TNF-alpha agents |
| format |
article |
| author |
Bounia CA Theodoropoulou EN Liossis SNC |
| author_facet |
Bounia CA Theodoropoulou EN Liossis SNC |
| author_sort |
Bounia CA |
| title |
Glomerulonephritis in Two Patients with SpA Treated with TNF-α Blockers and a Review of the Literature |
| title_short |
Glomerulonephritis in Two Patients with SpA Treated with TNF-α Blockers and a Review of the Literature |
| title_full |
Glomerulonephritis in Two Patients with SpA Treated with TNF-α Blockers and a Review of the Literature |
| title_fullStr |
Glomerulonephritis in Two Patients with SpA Treated with TNF-α Blockers and a Review of the Literature |
| title_full_unstemmed |
Glomerulonephritis in Two Patients with SpA Treated with TNF-α Blockers and a Review of the Literature |
| title_sort |
glomerulonephritis in two patients with spa treated with tnf-α blockers and a review of the literature |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/ad9096b4f0684a9b98876462563f1d88 |
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