Tenascin-C drives persistence of organ fibrosis

Systemic sclerosis (SSc) is a fibrotic disease affecting multiple organs. Here the authors use patient samples plus mouse studies to show a central role for tenascin C as a TLR4 activator responsible for persistence of fibrosis in the context of SSc and SSc-like disease.

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Detalles Bibliográficos
Autores principales:	Swati Bhattacharyya, Wenxia Wang, Luisa Morales-Nebreda, Gang Feng, Minghua Wu, Xiaodong Zhou, Robert Lafyatis, Jungwha Lee, Monique Hinchcliff, Carol Feghali-Bostwick, Katja Lakota, G. R. Scott Budinger, Kirtee Raparia, Zenshiro Tamaki, John Varga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad972eca9c0b4547b31a8d0ec137cae1
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spelling	oai:doaj.org-article:ad972eca9c0b4547b31a8d0ec137cae12021-12-02T15:35:26ZTenascin-C drives persistence of organ fibrosis10.1038/ncomms117032041-1723https://doaj.org/article/ad972eca9c0b4547b31a8d0ec137cae12016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11703https://doaj.org/toc/2041-1723Systemic sclerosis (SSc) is a fibrotic disease affecting multiple organs. Here the authors use patient samples plus mouse studies to show a central role for tenascin C as a TLR4 activator responsible for persistence of fibrosis in the context of SSc and SSc-like disease.Swati BhattacharyyaWenxia WangLuisa Morales-NebredaGang FengMinghua WuXiaodong ZhouRobert LafyatisJungwha LeeMonique HinchcliffCarol Feghali-BostwickKatja LakotaG. R. Scott BudingerKirtee RapariaZenshiro TamakiJohn VargaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Swati Bhattacharyya Wenxia Wang Luisa Morales-Nebreda Gang Feng Minghua Wu Xiaodong Zhou Robert Lafyatis Jungwha Lee Monique Hinchcliff Carol Feghali-Bostwick Katja Lakota G. R. Scott Budinger Kirtee Raparia Zenshiro Tamaki John Varga Tenascin-C drives persistence of organ fibrosis
description	Systemic sclerosis (SSc) is a fibrotic disease affecting multiple organs. Here the authors use patient samples plus mouse studies to show a central role for tenascin C as a TLR4 activator responsible for persistence of fibrosis in the context of SSc and SSc-like disease.
format	article
author	Swati Bhattacharyya Wenxia Wang Luisa Morales-Nebreda Gang Feng Minghua Wu Xiaodong Zhou Robert Lafyatis Jungwha Lee Monique Hinchcliff Carol Feghali-Bostwick Katja Lakota G. R. Scott Budinger Kirtee Raparia Zenshiro Tamaki John Varga
author_facet	Swati Bhattacharyya Wenxia Wang Luisa Morales-Nebreda Gang Feng Minghua Wu Xiaodong Zhou Robert Lafyatis Jungwha Lee Monique Hinchcliff Carol Feghali-Bostwick Katja Lakota G. R. Scott Budinger Kirtee Raparia Zenshiro Tamaki John Varga
author_sort	Swati Bhattacharyya
title	Tenascin-C drives persistence of organ fibrosis
title_short	Tenascin-C drives persistence of organ fibrosis
title_full	Tenascin-C drives persistence of organ fibrosis
title_fullStr	Tenascin-C drives persistence of organ fibrosis
title_full_unstemmed	Tenascin-C drives persistence of organ fibrosis
title_sort	tenascin-c drives persistence of organ fibrosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ad972eca9c0b4547b31a8d0ec137cae1
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Tenascin-C drives persistence of organ fibrosis

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