Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications

Baozhang Guan,1 Xingwang Zhang2 1Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, People’s Republic of China; 2Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, People’s Republic of ChinaCorresponde...

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Autores principales:	Guan B, Zhang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	aptamer theranostics biosensor biomedical imaging drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ad9a238bd2614f5eb3c45de64fdf6a19
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spelling	oai:doaj.org-article:ad9a238bd2614f5eb3c45de64fdf6a192021-12-02T09:17:47ZAptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications1178-2013https://doaj.org/article/ad9a238bd2614f5eb3c45de64fdf6a192020-02-01T00:00:00Zhttps://www.dovepress.com/aptamers-as-versatile-ligands-for-biomedical-and-pharmaceutical-applic-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Baozhang Guan,1 Xingwang Zhang2 1Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, People’s Republic of China; 2Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, People’s Republic of ChinaCorrespondence: Xingwang ZhangDepartment of Pharmaceutics, College of Pharmacy, Jinan University, 601 West Huangpu Avenue, Guangzhou 510632, People’s Republic of ChinaEmail zhangxw@jnu.edu.cnAbstract: Aptamers are a class of targeting ligands that bind exclusively to biomarkers of interest. Aptamers have been identified as candidates for the construction of various smart systems for therapy, diagnosis, bioimaging, and drug delivery due to their high target affinity and specificity. Aptamers are accounted as chemical antibodies that can be readily linked to drugs, sensors, signal enhancers, or nanocarriers for functionalization. Use of aptamer-guided medications, especially nanomedicines, has resulted in encouraging outcomes compared to those use of aptamer-free counterparts. This article reviews recent advances in the use of aptamers as targeting ligands for various biomedical and pharmaceutical purposes. Special interests focus on aptamer-based theranostics, biosensing, bioimaging, drug potentiation, and targeted drug delivery.Keywords: aptamer, theranostics, biosensor, biomedical imaging, drug deliveryGuan BZhang XDove Medical Pressarticleaptamertheranosticsbiosensorbiomedical imagingdrug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 1059-1071 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	aptamer theranostics biosensor biomedical imaging drug delivery Medicine (General) R5-920
spellingShingle	aptamer theranostics biosensor biomedical imaging drug delivery Medicine (General) R5-920 Guan B Zhang X Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications
description	Baozhang Guan,1 Xingwang Zhang2 1Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, People’s Republic of China; 2Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, People’s Republic of ChinaCorrespondence: Xingwang ZhangDepartment of Pharmaceutics, College of Pharmacy, Jinan University, 601 West Huangpu Avenue, Guangzhou 510632, People’s Republic of ChinaEmail zhangxw@jnu.edu.cnAbstract: Aptamers are a class of targeting ligands that bind exclusively to biomarkers of interest. Aptamers have been identified as candidates for the construction of various smart systems for therapy, diagnosis, bioimaging, and drug delivery due to their high target affinity and specificity. Aptamers are accounted as chemical antibodies that can be readily linked to drugs, sensors, signal enhancers, or nanocarriers for functionalization. Use of aptamer-guided medications, especially nanomedicines, has resulted in encouraging outcomes compared to those use of aptamer-free counterparts. This article reviews recent advances in the use of aptamers as targeting ligands for various biomedical and pharmaceutical purposes. Special interests focus on aptamer-based theranostics, biosensing, bioimaging, drug potentiation, and targeted drug delivery.Keywords: aptamer, theranostics, biosensor, biomedical imaging, drug delivery
format	article
author	Guan B Zhang X
author_facet	Guan B Zhang X
author_sort	Guan B
title	Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications
title_short	Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications
title_full	Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications
title_fullStr	Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications
title_full_unstemmed	Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications
title_sort	aptamers as versatile ligands for biomedical and pharmaceutical applications
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ad9a238bd2614f5eb3c45de64fdf6a19
work_keys_str_mv	AT guanb aptamersasversatileligandsforbiomedicalandpharmaceuticalapplications AT zhangx aptamersasversatileligandsforbiomedicalandpharmaceuticalapplications
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Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications

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