Predictability of painful stimulation modulates the somatosensory-evoked potential in the rat.

Somatosensory-evoked potentials (SEPs) are used in humans and animals to increase knowledge about nociception and pain. Since the SEP in humans increases when noxious stimuli are administered unpredictably, predictability potentially influences the SEP in animals as well. To assess the effect of pre...

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Autores principales:	Manon W H Schaap, Hugo van Oostrom, Arie Doornenbal, Annemarie M Baars, Saskia S Arndt, Ludo J Hellebrekers
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad9ce3be871f4af78218020a382d37a8
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spelling	oai:doaj.org-article:ad9ce3be871f4af78218020a382d37a82021-11-18T07:49:19ZPredictability of painful stimulation modulates the somatosensory-evoked potential in the rat.1932-620310.1371/journal.pone.0061487https://doaj.org/article/ad9ce3be871f4af78218020a382d37a82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23613862/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Somatosensory-evoked potentials (SEPs) are used in humans and animals to increase knowledge about nociception and pain. Since the SEP in humans increases when noxious stimuli are administered unpredictably, predictability potentially influences the SEP in animals as well. To assess the effect of predictability on the SEP in animals, classical fear conditioning was applied to compare SEPs between rats receiving SEP-evoking electrical stimuli either predictably or unpredictably. As in humans, the rat's SEP increased when SEP-evoking stimuli were administered unpredictably. These data support the hypothesis that the predictability of noxious stimuli plays a distinctive role in the processing of these stimuli in animals. The influence of predictability should be considered when studying nociception and pain in animals. Additionally, this finding suggests that animals confronted with (un)predictable noxious stimuli can be used to investigate the mechanisms underlying the influence of predictability on central processing of noxious stimuli.Manon W H SchaapHugo van OostromArie DoornenbalAnnemarie M BaarsSaskia S ArndtLudo J HellebrekersPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61487 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manon W H Schaap Hugo van Oostrom Arie Doornenbal Annemarie M Baars Saskia S Arndt Ludo J Hellebrekers Predictability of painful stimulation modulates the somatosensory-evoked potential in the rat.
description	Somatosensory-evoked potentials (SEPs) are used in humans and animals to increase knowledge about nociception and pain. Since the SEP in humans increases when noxious stimuli are administered unpredictably, predictability potentially influences the SEP in animals as well. To assess the effect of predictability on the SEP in animals, classical fear conditioning was applied to compare SEPs between rats receiving SEP-evoking electrical stimuli either predictably or unpredictably. As in humans, the rat's SEP increased when SEP-evoking stimuli were administered unpredictably. These data support the hypothesis that the predictability of noxious stimuli plays a distinctive role in the processing of these stimuli in animals. The influence of predictability should be considered when studying nociception and pain in animals. Additionally, this finding suggests that animals confronted with (un)predictable noxious stimuli can be used to investigate the mechanisms underlying the influence of predictability on central processing of noxious stimuli.
format	article
author	Manon W H Schaap Hugo van Oostrom Arie Doornenbal Annemarie M Baars Saskia S Arndt Ludo J Hellebrekers
author_facet	Manon W H Schaap Hugo van Oostrom Arie Doornenbal Annemarie M Baars Saskia S Arndt Ludo J Hellebrekers
author_sort	Manon W H Schaap
title	Predictability of painful stimulation modulates the somatosensory-evoked potential in the rat.
title_short	Predictability of painful stimulation modulates the somatosensory-evoked potential in the rat.
title_full	Predictability of painful stimulation modulates the somatosensory-evoked potential in the rat.
title_fullStr	Predictability of painful stimulation modulates the somatosensory-evoked potential in the rat.
title_full_unstemmed	Predictability of painful stimulation modulates the somatosensory-evoked potential in the rat.
title_sort	predictability of painful stimulation modulates the somatosensory-evoked potential in the rat.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ad9ce3be871f4af78218020a382d37a8
work_keys_str_mv	AT manonwhschaap predictabilityofpainfulstimulationmodulatesthesomatosensoryevokedpotentialintherat AT hugovanoostrom predictabilityofpainfulstimulationmodulatesthesomatosensoryevokedpotentialintherat AT ariedoornenbal predictabilityofpainfulstimulationmodulatesthesomatosensoryevokedpotentialintherat AT annemariembaars predictabilityofpainfulstimulationmodulatesthesomatosensoryevokedpotentialintherat AT saskiasarndt predictabilityofpainfulstimulationmodulatesthesomatosensoryevokedpotentialintherat AT ludojhellebrekers predictabilityofpainfulstimulationmodulatesthesomatosensoryevokedpotentialintherat
_version_	1718422931966525440

Predictability of painful stimulation modulates the somatosensory-evoked potential in the rat.

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