A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital

Absract Background To describe the course and intervention of an hospital-wide IMI-Producing Enterobacter ludwigii outbreak. Methods This was an outbreak interventional study, done at a tertiary care center in Tel-Aviv, Israel. Data was collected on the course of the outbreak and the demographic and...

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Autores principales:	Vered Schechner, Katya Levytskyi, Ohad Shalom, Alexander Yalek, Amos Adler
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	IMI Outbreak Carbapenemase Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/ad9d7e5985294d8c91921b60fcca024a
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spelling	oai:doaj.org-article:ad9d7e5985294d8c91921b60fcca024a2021-12-05T12:24:05ZA hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital10.1186/s13756-021-01036-02047-2994https://doaj.org/article/ad9d7e5985294d8c91921b60fcca024a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13756-021-01036-0https://doaj.org/toc/2047-2994Absract Background To describe the course and intervention of an hospital-wide IMI-Producing Enterobacter ludwigii outbreak. Methods This was an outbreak interventional study, done at a tertiary care center in Tel-Aviv, Israel. Data was collected on the course of the outbreak and the demographic and clinical characteristics of all patients involved in the outbreak. The intervention measures included patients’ cohorting, contact isolation precautions, environmental cleaning and screening of contacts. The molecular features and phylogeny of outbreak-related isolates were studied by whole-genome based analysis. Results The outbreak included 34 patients that were colonized by IMI-Producing E. ludwigii and were identified in 24 wards throughout the hospital. Colonization was identified in the first 72 h of admission in 13/34 patients (38.2%). Most patients (91.2%) were admitted from home and had relatively low level of comorbidities. The majority of them (88%) had no recent use of invasive catheters and none had previous carriage of other multi-drug resistant bacteria. All available isolates harbored the bla IMI-17 allele and belonged to Sequence-Type 385. With the exception of two isolates, all isolates were closely related with less than a 20-SNP difference between them. Conclusions This outbreak had most likely originated in the community and subsequently disseminated inside our institution. More studies are required in order to elucidate the epidemiology of IMI-Producing E. ludwigii and the possible role of environmental sources in its dissemination.Vered SchechnerKatya LevytskyiOhad ShalomAlexander YalekAmos AdlerBMCarticleIMIOutbreakCarbapenemaseInfectious and parasitic diseasesRC109-216ENAntimicrobial Resistance and Infection Control, Vol 10, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IMI Outbreak Carbapenemase Infectious and parasitic diseases RC109-216
spellingShingle	IMI Outbreak Carbapenemase Infectious and parasitic diseases RC109-216 Vered Schechner Katya Levytskyi Ohad Shalom Alexander Yalek Amos Adler A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
description	Absract Background To describe the course and intervention of an hospital-wide IMI-Producing Enterobacter ludwigii outbreak. Methods This was an outbreak interventional study, done at a tertiary care center in Tel-Aviv, Israel. Data was collected on the course of the outbreak and the demographic and clinical characteristics of all patients involved in the outbreak. The intervention measures included patients’ cohorting, contact isolation precautions, environmental cleaning and screening of contacts. The molecular features and phylogeny of outbreak-related isolates were studied by whole-genome based analysis. Results The outbreak included 34 patients that were colonized by IMI-Producing E. ludwigii and were identified in 24 wards throughout the hospital. Colonization was identified in the first 72 h of admission in 13/34 patients (38.2%). Most patients (91.2%) were admitted from home and had relatively low level of comorbidities. The majority of them (88%) had no recent use of invasive catheters and none had previous carriage of other multi-drug resistant bacteria. All available isolates harbored the bla IMI-17 allele and belonged to Sequence-Type 385. With the exception of two isolates, all isolates were closely related with less than a 20-SNP difference between them. Conclusions This outbreak had most likely originated in the community and subsequently disseminated inside our institution. More studies are required in order to elucidate the epidemiology of IMI-Producing E. ludwigii and the possible role of environmental sources in its dissemination.
format	article
author	Vered Schechner Katya Levytskyi Ohad Shalom Alexander Yalek Amos Adler
author_facet	Vered Schechner Katya Levytskyi Ohad Shalom Alexander Yalek Amos Adler
author_sort	Vered Schechner
title	A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
title_short	A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
title_full	A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
title_fullStr	A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
title_full_unstemmed	A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
title_sort	hospital-wide outbreak of imi-17-producing enterobacter ludwigii in an israeli hospital
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ad9d7e5985294d8c91921b60fcca024a
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A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital

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