Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition

Preeclampsia is one of the most common obstetrical complications worldwide. The pathomechanism of this disease begins with abnormal placentation in early pregnancy, which is associated with inappropriate decidualization, vasculogenesis, angiogenesis, and spiral artery remodeling, leading to endothel...

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Autores principales:	Angga Wiratama Lokeswara, Rabbania Hiksas, Rima Irwinda, Noroyono Wibowo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cellular wellness cell death apoptosis autophagy preeclampsia nutrition Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ad9ef47e79ab4335b602a62ed5a913b0
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spelling	oai:doaj.org-article:ad9ef47e79ab4335b602a62ed5a913b02021-11-05T13:22:01ZPreeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition2296-634X10.3389/fcell.2021.726513https://doaj.org/article/ad9ef47e79ab4335b602a62ed5a913b02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.726513/fullhttps://doaj.org/toc/2296-634XPreeclampsia is one of the most common obstetrical complications worldwide. The pathomechanism of this disease begins with abnormal placentation in early pregnancy, which is associated with inappropriate decidualization, vasculogenesis, angiogenesis, and spiral artery remodeling, leading to endothelial dysfunction. In these processes, appropriate cellular deaths have been proposed to play a pivotal role, including apoptosis and autophagy. The proper functioning of these physiological cell deaths for placentation depends on the wellbeing of the trophoblasts, affected by the structural and functional integrity of each cellular component including the cell membrane, mitochondria, endoplasmic reticulum, genetics, and epigenetics. This cellular wellness, which includes optimal cellular integrity and function, is heavily influenced by nutritional adequacy. In contrast, nutritional deficiencies may result in the alteration of plasma membrane, mitochondrial dysfunction, endoplasmic reticulum stress, and changes in gene expression, DNA methylation, and miRNA expression, as well as weakened defense against environmental contaminants, hence inducing a series of inappropriate cellular deaths such as abnormal apoptosis and necrosis, and autophagy dysfunction and resulting in abnormal trophoblast invasion. Despite their inherent connection, the currently available studies examined the functions of each organelle, the cellular death mechanisms and the nutrition involved, both physiologically in the placenta and in preeclampsia, separately. Therefore, this review aims to comprehensively discuss the relationship between each organelle in maintaining the physiological cell death mechanisms and the nutrition involved, and the interconnection between the disruptions in the cellular organelles and inappropriate cell death mechanisms, resulting in poor trophoblast invasion and differentiation, as seen in preeclampsia.Angga Wiratama LokeswaraRabbania HiksasRima IrwindaNoroyono WibowoFrontiers Media S.A.articlecellular wellnesscell deathapoptosisautophagypreeclampsianutritionBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cellular wellness cell death apoptosis autophagy preeclampsia nutrition Biology (General) QH301-705.5
spellingShingle	cellular wellness cell death apoptosis autophagy preeclampsia nutrition Biology (General) QH301-705.5 Angga Wiratama Lokeswara Rabbania Hiksas Rima Irwinda Noroyono Wibowo Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition
description	Preeclampsia is one of the most common obstetrical complications worldwide. The pathomechanism of this disease begins with abnormal placentation in early pregnancy, which is associated with inappropriate decidualization, vasculogenesis, angiogenesis, and spiral artery remodeling, leading to endothelial dysfunction. In these processes, appropriate cellular deaths have been proposed to play a pivotal role, including apoptosis and autophagy. The proper functioning of these physiological cell deaths for placentation depends on the wellbeing of the trophoblasts, affected by the structural and functional integrity of each cellular component including the cell membrane, mitochondria, endoplasmic reticulum, genetics, and epigenetics. This cellular wellness, which includes optimal cellular integrity and function, is heavily influenced by nutritional adequacy. In contrast, nutritional deficiencies may result in the alteration of plasma membrane, mitochondrial dysfunction, endoplasmic reticulum stress, and changes in gene expression, DNA methylation, and miRNA expression, as well as weakened defense against environmental contaminants, hence inducing a series of inappropriate cellular deaths such as abnormal apoptosis and necrosis, and autophagy dysfunction and resulting in abnormal trophoblast invasion. Despite their inherent connection, the currently available studies examined the functions of each organelle, the cellular death mechanisms and the nutrition involved, both physiologically in the placenta and in preeclampsia, separately. Therefore, this review aims to comprehensively discuss the relationship between each organelle in maintaining the physiological cell death mechanisms and the nutrition involved, and the interconnection between the disruptions in the cellular organelles and inappropriate cell death mechanisms, resulting in poor trophoblast invasion and differentiation, as seen in preeclampsia.
format	article
author	Angga Wiratama Lokeswara Rabbania Hiksas Rima Irwinda Noroyono Wibowo
author_facet	Angga Wiratama Lokeswara Rabbania Hiksas Rima Irwinda Noroyono Wibowo
author_sort	Angga Wiratama Lokeswara
title	Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition
title_short	Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition
title_full	Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition
title_fullStr	Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition
title_full_unstemmed	Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition
title_sort	preeclampsia: from cellular wellness to inappropriate cell death, and the roles of nutrition
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ad9ef47e79ab4335b602a62ed5a913b0
work_keys_str_mv	AT anggawiratamalokeswara preeclampsiafromcellularwellnesstoinappropriatecelldeathandtherolesofnutrition AT rabbaniahiksas preeclampsiafromcellularwellnesstoinappropriatecelldeathandtherolesofnutrition AT rimairwinda preeclampsiafromcellularwellnesstoinappropriatecelldeathandtherolesofnutrition AT noroyonowibowo preeclampsiafromcellularwellnesstoinappropriatecelldeathandtherolesofnutrition
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Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition

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