Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study
Abstract The objective of the study was to evaluate the clinicopathological characteristics and investigate the clinical determinants of patient and renal survival in the first 12 months after diagnosis in anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis (AAV) patients with hy...
Guardado en:
Autores principales: | , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/ad9f52da1b0848c2ab2a861bb9be2d44 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:ad9f52da1b0848c2ab2a861bb9be2d44 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:ad9f52da1b0848c2ab2a861bb9be2d442021-12-02T15:23:47ZClinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study10.1038/s41598-021-81664-z2045-2322https://doaj.org/article/ad9f52da1b0848c2ab2a861bb9be2d442021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81664-zhttps://doaj.org/toc/2045-2322Abstract The objective of the study was to evaluate the clinicopathological characteristics and investigate the clinical determinants of patient and renal survival in the first 12 months after diagnosis in anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis (AAV) patients with hyperuricemia. This was a retrospective case-control study in patients with AAV-related renal injury in the First Affiliated Hospital of Zhengzhou University from January 2014 to April 2019. Patients who met the study criteria were divided into two groups: patients without hyperuricemia (n = 92) and patients with hyperuricemia (n = 55). Participants were followed-up for 12 months, and progressing to end-stage renal disease (ESRD) and death was treated as the endpoint event. We found that the level of serum creatinine was an independent risk factor for hyperuricemia, and the level of serum uric acid was an independent risk factors for renal survival and patient survival in ANCA-associated renal vasculitis patients. The crescents formation and the proportion of fibrous crescent likely contributed to severe clinical characteristics and renal pathological changes in ANCA-associated renal vasculitis patients with hyperuricemia. Hyperuricemia has an important influence on the progression of ANCA-associated renal vasculitis. A good control of serum uric acid may improve the prognosis.Ruiqiang WangDongyue AnYunqi WuPupu MaYuanyuan GuoLin TangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Ruiqiang Wang Dongyue An Yunqi Wu Pupu Ma Yuanyuan Guo Lin Tang Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study |
description |
Abstract The objective of the study was to evaluate the clinicopathological characteristics and investigate the clinical determinants of patient and renal survival in the first 12 months after diagnosis in anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis (AAV) patients with hyperuricemia. This was a retrospective case-control study in patients with AAV-related renal injury in the First Affiliated Hospital of Zhengzhou University from January 2014 to April 2019. Patients who met the study criteria were divided into two groups: patients without hyperuricemia (n = 92) and patients with hyperuricemia (n = 55). Participants were followed-up for 12 months, and progressing to end-stage renal disease (ESRD) and death was treated as the endpoint event. We found that the level of serum creatinine was an independent risk factor for hyperuricemia, and the level of serum uric acid was an independent risk factors for renal survival and patient survival in ANCA-associated renal vasculitis patients. The crescents formation and the proportion of fibrous crescent likely contributed to severe clinical characteristics and renal pathological changes in ANCA-associated renal vasculitis patients with hyperuricemia. Hyperuricemia has an important influence on the progression of ANCA-associated renal vasculitis. A good control of serum uric acid may improve the prognosis. |
format |
article |
author |
Ruiqiang Wang Dongyue An Yunqi Wu Pupu Ma Yuanyuan Guo Lin Tang |
author_facet |
Ruiqiang Wang Dongyue An Yunqi Wu Pupu Ma Yuanyuan Guo Lin Tang |
author_sort |
Ruiqiang Wang |
title |
Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study |
title_short |
Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study |
title_full |
Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study |
title_fullStr |
Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study |
title_full_unstemmed |
Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study |
title_sort |
clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/ad9f52da1b0848c2ab2a861bb9be2d44 |
work_keys_str_mv |
AT ruiqiangwang clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy AT dongyuean clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy AT yunqiwu clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy AT pupuma clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy AT yuanyuanguo clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy AT lintang clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy |
_version_ |
1718387284547469312 |