Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study

Abstract The objective of the study was to evaluate the clinicopathological characteristics and investigate the clinical determinants of patient and renal survival in the first 12 months after diagnosis in anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis (AAV) patients with hy...

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Autores principales:	Ruiqiang Wang, Dongyue An, Yunqi Wu, Pupu Ma, Yuanyuan Guo, Lin Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad9f52da1b0848c2ab2a861bb9be2d44
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spelling	oai:doaj.org-article:ad9f52da1b0848c2ab2a861bb9be2d442021-12-02T15:23:47ZClinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study10.1038/s41598-021-81664-z2045-2322https://doaj.org/article/ad9f52da1b0848c2ab2a861bb9be2d442021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81664-zhttps://doaj.org/toc/2045-2322Abstract The objective of the study was to evaluate the clinicopathological characteristics and investigate the clinical determinants of patient and renal survival in the first 12 months after diagnosis in anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis (AAV) patients with hyperuricemia. This was a retrospective case-control study in patients with AAV-related renal injury in the First Affiliated Hospital of Zhengzhou University from January 2014 to April 2019. Patients who met the study criteria were divided into two groups: patients without hyperuricemia (n = 92) and patients with hyperuricemia (n = 55). Participants were followed-up for 12 months, and progressing to end-stage renal disease (ESRD) and death was treated as the endpoint event. We found that the level of serum creatinine was an independent risk factor for hyperuricemia, and the level of serum uric acid was an independent risk factors for renal survival and patient survival in ANCA-associated renal vasculitis patients. The crescents formation and the proportion of fibrous crescent likely contributed to severe clinical characteristics and renal pathological changes in ANCA-associated renal vasculitis patients with hyperuricemia. Hyperuricemia has an important influence on the progression of ANCA-associated renal vasculitis. A good control of serum uric acid may improve the prognosis.Ruiqiang WangDongyue AnYunqi WuPupu MaYuanyuan GuoLin TangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruiqiang Wang Dongyue An Yunqi Wu Pupu Ma Yuanyuan Guo Lin Tang Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study
description	Abstract The objective of the study was to evaluate the clinicopathological characteristics and investigate the clinical determinants of patient and renal survival in the first 12 months after diagnosis in anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis (AAV) patients with hyperuricemia. This was a retrospective case-control study in patients with AAV-related renal injury in the First Affiliated Hospital of Zhengzhou University from January 2014 to April 2019. Patients who met the study criteria were divided into two groups: patients without hyperuricemia (n = 92) and patients with hyperuricemia (n = 55). Participants were followed-up for 12 months, and progressing to end-stage renal disease (ESRD) and death was treated as the endpoint event. We found that the level of serum creatinine was an independent risk factor for hyperuricemia, and the level of serum uric acid was an independent risk factors for renal survival and patient survival in ANCA-associated renal vasculitis patients. The crescents formation and the proportion of fibrous crescent likely contributed to severe clinical characteristics and renal pathological changes in ANCA-associated renal vasculitis patients with hyperuricemia. Hyperuricemia has an important influence on the progression of ANCA-associated renal vasculitis. A good control of serum uric acid may improve the prognosis.
format	article
author	Ruiqiang Wang Dongyue An Yunqi Wu Pupu Ma Yuanyuan Guo Lin Tang
author_facet	Ruiqiang Wang Dongyue An Yunqi Wu Pupu Ma Yuanyuan Guo Lin Tang
author_sort	Ruiqiang Wang
title	Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study
title_short	Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study
title_full	Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study
title_fullStr	Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study
title_full_unstemmed	Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study
title_sort	clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad9f52da1b0848c2ab2a861bb9be2d44
work_keys_str_mv	AT ruiqiangwang clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy AT dongyuean clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy AT yunqiwu clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy AT pupuma clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy AT yuanyuanguo clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy AT lintang clinicopathologicalcharacteristicsandoutcomesofantineutrophilcytoplasmicautoantibodyrelatedrenalvasculitiswithhyperuricemiaaretrospectivecasecontrolstudy
_version_	1718387284547469312

Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study

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