CHARACTERISTICS OF NEUTROPHILIC GRANULOCYTES IN POLYPOUS RHINOSINUSITIS

We have studied functional parameters of neutrophilic granulocytes in patients with polypous rhinosinusitis by means of luminol- or lucigeninependent chemiluminescence induced by zymosan and Staphylococcus aureus. Luminol-enhanced chemiluminescence registered the entire pool of reactive oxygen speci...

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Autores principales:	O. A. Kolenchukova, S. V. Smirnova, A. A. Savchenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	neutrophilic granulocytes functional activity staphylococcus aureus zimozan luminol lucigenin polypous rhinosinusitis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ada1b22182194697ad391c46506a03ab
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spelling	oai:doaj.org-article:ada1b22182194697ad391c46506a03ab2021-11-18T08:03:43ZCHARACTERISTICS OF NEUTROPHILIC GRANULOCYTES IN POLYPOUS RHINOSINUSITIS1563-06252313-741X10.15789/1563-0625-2014-4-385-390https://doaj.org/article/ada1b22182194697ad391c46506a03ab2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/706https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe have studied functional parameters of neutrophilic granulocytes in patients with polypous rhinosinusitis by means of luminol- or lucigeninependent chemiluminescence induced by zymosan and Staphylococcus aureus. Luminol-enhanced chemiluminescence registered the entire pool of reactive oxygen species (ROS), reflecting total activity of myeloperoxidase and NADPH oxidase etc., whereas lucigenindependent chemiluminescence detected production of superoxide radical anion (·О2 -), as well as NADPH oxidase activivity. Usage of the in vitro stimulation tests allows both modeling of disease conditions, and to suggest origins of granulocyte stimulation, their mobilization potential and integration of intracellular processes. We found the increased rate of ROS formation, both in spontaneous and induced chemiluminescent reaction in luminol-dependent process. We have studied neutrophilic granulocyte response to different stimuli and found an increased luminol-dependent ROS formation in polypous rhinosinusitis in response to bacterial induction.O. A. KolenchukovaS. V. SmirnovaA. A. SavchenkoSPb RAACIarticleneutrophilic granulocytesfunctional activitystaphylococcus aureuszimozanluminollucigeninpolypous rhinosinusitisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 4, Pp 385-390 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	neutrophilic granulocytes functional activity staphylococcus aureus zimozan luminol lucigenin polypous rhinosinusitis Immunologic diseases. Allergy RC581-607
spellingShingle	neutrophilic granulocytes functional activity staphylococcus aureus zimozan luminol lucigenin polypous rhinosinusitis Immunologic diseases. Allergy RC581-607 O. A. Kolenchukova S. V. Smirnova A. A. Savchenko CHARACTERISTICS OF NEUTROPHILIC GRANULOCYTES IN POLYPOUS RHINOSINUSITIS
description	We have studied functional parameters of neutrophilic granulocytes in patients with polypous rhinosinusitis by means of luminol- or lucigeninependent chemiluminescence induced by zymosan and Staphylococcus aureus. Luminol-enhanced chemiluminescence registered the entire pool of reactive oxygen species (ROS), reflecting total activity of myeloperoxidase and NADPH oxidase etc., whereas lucigenindependent chemiluminescence detected production of superoxide radical anion (·О2 -), as well as NADPH oxidase activivity. Usage of the in vitro stimulation tests allows both modeling of disease conditions, and to suggest origins of granulocyte stimulation, their mobilization potential and integration of intracellular processes. We found the increased rate of ROS formation, both in spontaneous and induced chemiluminescent reaction in luminol-dependent process. We have studied neutrophilic granulocyte response to different stimuli and found an increased luminol-dependent ROS formation in polypous rhinosinusitis in response to bacterial induction.
format	article
author	O. A. Kolenchukova S. V. Smirnova A. A. Savchenko
author_facet	O. A. Kolenchukova S. V. Smirnova A. A. Savchenko
author_sort	O. A. Kolenchukova
title	CHARACTERISTICS OF NEUTROPHILIC GRANULOCYTES IN POLYPOUS RHINOSINUSITIS
title_short	CHARACTERISTICS OF NEUTROPHILIC GRANULOCYTES IN POLYPOUS RHINOSINUSITIS
title_full	CHARACTERISTICS OF NEUTROPHILIC GRANULOCYTES IN POLYPOUS RHINOSINUSITIS
title_fullStr	CHARACTERISTICS OF NEUTROPHILIC GRANULOCYTES IN POLYPOUS RHINOSINUSITIS
title_full_unstemmed	CHARACTERISTICS OF NEUTROPHILIC GRANULOCYTES IN POLYPOUS RHINOSINUSITIS
title_sort	characteristics of neutrophilic granulocytes in polypous rhinosinusitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ada1b22182194697ad391c46506a03ab
work_keys_str_mv	AT oakolenchukova characteristicsofneutrophilicgranulocytesinpolypousrhinosinusitis AT svsmirnova characteristicsofneutrophilicgranulocytesinpolypousrhinosinusitis AT aasavchenko characteristicsofneutrophilicgranulocytesinpolypousrhinosinusitis
_version_	1718422441264414720

CHARACTERISTICS OF NEUTROPHILIC GRANULOCYTES IN POLYPOUS RHINOSINUSITIS

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