Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology

Abstract Increasing evidence has shown that Chinese herbal medicine (CHM) has promising therapeutic effects in colorectal cancer (CRC); however, the active ingredients and potential targets remain unclear. In this study, we aimed to investigate the relative molecular targets of the Chinese herbs tha...

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Autores principales:	Hongxu Zhu, Jian Hao, Yangyang Niu, Dan Liu, Dan Chen, Xiongzhi Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ada55a25927e4f579ffc749cc3c3fe0e
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spelling	oai:doaj.org-article:ada55a25927e4f579ffc749cc3c3fe0e2021-12-02T16:08:02ZMolecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology10.1038/s41598-018-25500-x2045-2322https://doaj.org/article/ada55a25927e4f579ffc749cc3c3fe0e2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25500-xhttps://doaj.org/toc/2045-2322Abstract Increasing evidence has shown that Chinese herbal medicine (CHM) has promising therapeutic effects in colorectal cancer (CRC); however, the active ingredients and potential targets remain unclear. In this study, we aimed to investigate the relative molecular targets of the Chinese herbs that have been found effective in treating metastatic CRC (mCRC) based on clinical data and network pharmacology. In multivariate analysis CHM resulted an independent prognostic factor. The hazard ratio was 0.103 (95% confidence interval = 0.064–0.164; P < 0.001). Compared with the non-CHM group, the median survival time of the CHM group was also improved (40 versus 12 months; P < 0.001). Eighteen out of 295 herbs showed significant correlation with survival results (P < 0.05). Bioinformatics analysis indicated that the 18 herbs realize anti-CRC activity mainly through suppressing the proliferative activity of ERBB2, peroxisome proliferator-activated receptor gamma, and retinoid X receptor, suppressing angiogenesis via inhibition of VEGFR and VEGFA expression, inhibiting the phosphatidylinositol-3-kinase/AKT1 signaling pathway directly through SRC and AKT1, and reducing tumor necrosis factor-induced inflammation.Hongxu ZhuJian HaoYangyang NiuDan LiuDan ChenXiongzhi WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongxu Zhu Jian Hao Yangyang Niu Dan Liu Dan Chen Xiongzhi Wu Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology
description	Abstract Increasing evidence has shown that Chinese herbal medicine (CHM) has promising therapeutic effects in colorectal cancer (CRC); however, the active ingredients and potential targets remain unclear. In this study, we aimed to investigate the relative molecular targets of the Chinese herbs that have been found effective in treating metastatic CRC (mCRC) based on clinical data and network pharmacology. In multivariate analysis CHM resulted an independent prognostic factor. The hazard ratio was 0.103 (95% confidence interval = 0.064–0.164; P < 0.001). Compared with the non-CHM group, the median survival time of the CHM group was also improved (40 versus 12 months; P < 0.001). Eighteen out of 295 herbs showed significant correlation with survival results (P < 0.05). Bioinformatics analysis indicated that the 18 herbs realize anti-CRC activity mainly through suppressing the proliferative activity of ERBB2, peroxisome proliferator-activated receptor gamma, and retinoid X receptor, suppressing angiogenesis via inhibition of VEGFR and VEGFA expression, inhibiting the phosphatidylinositol-3-kinase/AKT1 signaling pathway directly through SRC and AKT1, and reducing tumor necrosis factor-induced inflammation.
format	article
author	Hongxu Zhu Jian Hao Yangyang Niu Dan Liu Dan Chen Xiongzhi Wu
author_facet	Hongxu Zhu Jian Hao Yangyang Niu Dan Liu Dan Chen Xiongzhi Wu
author_sort	Hongxu Zhu
title	Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology
title_short	Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology
title_full	Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology
title_fullStr	Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology
title_full_unstemmed	Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology
title_sort	molecular targets of chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ada55a25927e4f579ffc749cc3c3fe0e
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Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology

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