Fractionated deep-inspiration breath-hold ZTE Compared with Free-breathing four-dimensional ZTE for detecting pulmonary nodules in oncological patients underwent PET/MRI

Abstract The zero echo time (ZTE) technique has improved the detection of lung nodules in PET/MRI but respiratory motion remains a challenge in lung scan. We investigated the feasibility and performance of fractionated deep-inspiration breath-hold (FDIBH) three-dimensional (3D) ZTE FDG PET/MRI for a...

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Autores principales:	Chih-Yung Chang, Tse-Hao Lee, Ren-Shyan Liu, Chien-Ying Li, Bang-Hung Yang, Wen-Yi Chang, Tzu-Ping Lin, Chi-Wei Chang, Shan-Fan Yao, Tzu-Chun Wei, Chien-Yuan Lin, Charng-Chyi Shieh, Chia-Feng Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/adb01b8e06a44964a4827dee11015ee6
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spelling	oai:doaj.org-article:adb01b8e06a44964a4827dee11015ee62021-12-02T15:28:46ZFractionated deep-inspiration breath-hold ZTE Compared with Free-breathing four-dimensional ZTE for detecting pulmonary nodules in oncological patients underwent PET/MRI10.1038/s41598-021-94702-72045-2322https://doaj.org/article/adb01b8e06a44964a4827dee11015ee62021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94702-7https://doaj.org/toc/2045-2322Abstract The zero echo time (ZTE) technique has improved the detection of lung nodules in PET/MRI but respiratory motion remains a challenge in lung scan. We investigated the feasibility and performance of fractionated deep-inspiration breath-hold (FDIBH) three-dimensional (3D) ZTE FDG PET/MRI for assessing lung nodules in patients with proved malignancy. Sixty patients who had undergone ZTE FDG PET/MRI and chest CT within a three-day interval were retrospectively included. Lung nodules less than 2 mm were excluded for analysis. Two physicians checked the adequacy of FDIBH ZTE and compared the lung nodule detection rates of FDIBH 3D ZTE and free-breathing (FB) four-dimensional (4D) ZTE, with chest CT as the reference standard. FDIBH resolved the effect of respiratory motion in 49 patients. The mean number and size of the pulmonary nodules identified in CT were 15 ± 31.3 per patient and 5.9 ± 4.6 mm in diameter. The overall nodule detection rate was 71% for FDIBH 3D ZTE and 70% for FB 4D ZTE (p = 0.73). FDIBH 3D ZTE significantly outperformed FB 4DZTE in detecting lung base nodules (72% and 68%; p = 0.03), especially for detecting those less than 6 mm (61% and 55%; p = 0.03). High inter-rater reliability for FDIBH 3D ZTE and FB 4D ZTE (k = 0.9 and 0.92) was noted. In conclusion, the capability of FDIBH 3D ZTE in respiratory motion resolution was limited with a technical failure rate of 18%. However, it could provide full expansion of the lung in a shorter scan time which enabled better detection of nodules (< 6 mm) in basal lungs, compared to FB 4D ZTE.Chih-Yung ChangTse-Hao LeeRen-Shyan LiuChien-Ying LiBang-Hung YangWen-Yi ChangTzu-Ping LinChi-Wei ChangShan-Fan YaoTzu-Chun WeiChien-Yuan LinCharng-Chyi ShiehChia-Feng LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chih-Yung Chang Tse-Hao Lee Ren-Shyan Liu Chien-Ying Li Bang-Hung Yang Wen-Yi Chang Tzu-Ping Lin Chi-Wei Chang Shan-Fan Yao Tzu-Chun Wei Chien-Yuan Lin Charng-Chyi Shieh Chia-Feng Lu Fractionated deep-inspiration breath-hold ZTE Compared with Free-breathing four-dimensional ZTE for detecting pulmonary nodules in oncological patients underwent PET/MRI
description	Abstract The zero echo time (ZTE) technique has improved the detection of lung nodules in PET/MRI but respiratory motion remains a challenge in lung scan. We investigated the feasibility and performance of fractionated deep-inspiration breath-hold (FDIBH) three-dimensional (3D) ZTE FDG PET/MRI for assessing lung nodules in patients with proved malignancy. Sixty patients who had undergone ZTE FDG PET/MRI and chest CT within a three-day interval were retrospectively included. Lung nodules less than 2 mm were excluded for analysis. Two physicians checked the adequacy of FDIBH ZTE and compared the lung nodule detection rates of FDIBH 3D ZTE and free-breathing (FB) four-dimensional (4D) ZTE, with chest CT as the reference standard. FDIBH resolved the effect of respiratory motion in 49 patients. The mean number and size of the pulmonary nodules identified in CT were 15 ± 31.3 per patient and 5.9 ± 4.6 mm in diameter. The overall nodule detection rate was 71% for FDIBH 3D ZTE and 70% for FB 4D ZTE (p = 0.73). FDIBH 3D ZTE significantly outperformed FB 4DZTE in detecting lung base nodules (72% and 68%; p = 0.03), especially for detecting those less than 6 mm (61% and 55%; p = 0.03). High inter-rater reliability for FDIBH 3D ZTE and FB 4D ZTE (k = 0.9 and 0.92) was noted. In conclusion, the capability of FDIBH 3D ZTE in respiratory motion resolution was limited with a technical failure rate of 18%. However, it could provide full expansion of the lung in a shorter scan time which enabled better detection of nodules (< 6 mm) in basal lungs, compared to FB 4D ZTE.
format	article
author	Chih-Yung Chang Tse-Hao Lee Ren-Shyan Liu Chien-Ying Li Bang-Hung Yang Wen-Yi Chang Tzu-Ping Lin Chi-Wei Chang Shan-Fan Yao Tzu-Chun Wei Chien-Yuan Lin Charng-Chyi Shieh Chia-Feng Lu
author_facet	Chih-Yung Chang Tse-Hao Lee Ren-Shyan Liu Chien-Ying Li Bang-Hung Yang Wen-Yi Chang Tzu-Ping Lin Chi-Wei Chang Shan-Fan Yao Tzu-Chun Wei Chien-Yuan Lin Charng-Chyi Shieh Chia-Feng Lu
author_sort	Chih-Yung Chang
title	Fractionated deep-inspiration breath-hold ZTE Compared with Free-breathing four-dimensional ZTE for detecting pulmonary nodules in oncological patients underwent PET/MRI
title_short	Fractionated deep-inspiration breath-hold ZTE Compared with Free-breathing four-dimensional ZTE for detecting pulmonary nodules in oncological patients underwent PET/MRI
title_full	Fractionated deep-inspiration breath-hold ZTE Compared with Free-breathing four-dimensional ZTE for detecting pulmonary nodules in oncological patients underwent PET/MRI
title_fullStr	Fractionated deep-inspiration breath-hold ZTE Compared with Free-breathing four-dimensional ZTE for detecting pulmonary nodules in oncological patients underwent PET/MRI
title_full_unstemmed	Fractionated deep-inspiration breath-hold ZTE Compared with Free-breathing four-dimensional ZTE for detecting pulmonary nodules in oncological patients underwent PET/MRI
title_sort	fractionated deep-inspiration breath-hold zte compared with free-breathing four-dimensional zte for detecting pulmonary nodules in oncological patients underwent pet/mri
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/adb01b8e06a44964a4827dee11015ee6
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Fractionated deep-inspiration breath-hold ZTE Compared with Free-breathing four-dimensional ZTE for detecting pulmonary nodules in oncological patients underwent PET/MRI

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