Optimization the Spray-Drying Process of Moldavian Balm Plant Extract using Response Surface Methodology and TOPSIS Method

Introduction Dracocephalum moldavica L. is an annual plant with blue or white flowers and fragrant leaves which belongs to the family of Lamiaceae with the height of up to 80 cm. This plant is native to Central Asia and is accepted in Central and Eastern Europe. In Iran, it is mainly grown in the pr...

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Autores principales:	E Rahmati, F Sharifian, M Fattahi, Gh Najafi
Formato:	article
Lenguaje:	EN FA
Publicado:	Ferdowsi University of Mashhad 2020
Materias:	optimization spray-drying topsis method rsm method drying conditions moldavian balm powder Agriculture (General) S1-972 Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/adb140abdaf04519bf115564011251da
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id	oai:doaj.org-article:adb140abdaf04519bf115564011251da
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN FA
topic	optimization spray-drying topsis method rsm method drying conditions moldavian balm powder Agriculture (General) S1-972 Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	optimization spray-drying topsis method rsm method drying conditions moldavian balm powder Agriculture (General) S1-972 Engineering (General). Civil engineering (General) TA1-2040 E Rahmati F Sharifian M Fattahi Gh Najafi Optimization the Spray-Drying Process of Moldavian Balm Plant Extract using Response Surface Methodology and TOPSIS Method
description	Introduction Dracocephalum moldavica L. is an annual plant with blue or white flowers and fragrant leaves which belongs to the family of Lamiaceae with the height of up to 80 cm. This plant is native to Central Asia and is accepted in Central and Eastern Europe. In Iran, it is mainly grown in the province of West Azarbaijan and the Alborz Mountains. The essential oils and extracts derived from the secondary metabolisms which are mainly used in the pharmaceutical industry, dietary, cosmetic, flavoring and also as tea and beverage with sugar or honey. The liquid extract of the herb contains a high percentage of water, which should evaporate to increase shelf-life, easy transport, handling and storage, the ease of standardization and preservation of the product quality. On the other hand, the active compounds of the extracts are affected by temperature, oxygen, light and enzymes. Therefore, because of the uses and benefits of herbal extracts, they need to be dried by a practical and effective method like spray drying. In literature still there are no studies taking into account to the comparisons between RSM and TOPSIS as two important optimization methods. So, as the main objective of the present work, the effects of moisture content, drying performance, total phenol content, total flavonoid content and antioxidant activity have been surveyed. Finally, the optimal point of each process variable was presented by two optimization methods. Materials and Methods Aerial parts of Moldavian balm plant were cleaned and drying of plant was carried out under shade and thin layer conditions. The extraction of Moldavian balm was obtained by maceration method using ethanol 50 % (v/v), plant to solvent ratio of 1/10 (w/v). After 48h, the extract was concentrated in a rotary evaporator (Buchi Rotavapor R-205, Switzerland) to obtain a solid concentration of 6%. The used carrier was: Maltodextrin and apple pectin. Different ratios of carrier were prepared, then the ratio was added to distilled water and stirred by a magnetic stirrer. Finally, the solution was mixed with extract. The drying of Moldavian Balm plant extract was performed using a spray-dryer (Büchi B-191, Switzerland) with co-current flow regime. The powders provided by the spray drying were stored in refrigerator until they were needed for the experiment. Results and Discussion The results of variance analysis showed that the Box-Behnken design with the second-order model has led to the meaningfulness of the model, insignificant of the Lack of Fit and the appropriate correlation coefficient for each of the responses. A total number of 15 experiments were conducted to investigate the effect of process variables such as inlet air temperature, compressed air flow rate and concentration of carriers on moisture content, drying performance, total phenolic content, total flavonoid content and antioxidant activity of Moldavian balm powder. Inlet air temperature and compressed air flow rate had the most significant effect on moisture content and drying performance, while Chemical properties of the powder affected by changing the concentration of carriers. Optimization parameters of the spray drying process was performed using surface response and TOPSIS methods. The optimum predicted conditions in the response surface method and TOPSIS method were obtained at inlet air temperature, compressed air flow rate and concentration of carrier (152.5-150°C), (8.046-7.5 lit min-1) and 20%, respectively. Conclusions By comparing two methods, it can be concluded that although they could provide the same optimum points, the RSM is more efficient. Because RSM offers a mathematical model that can be used at any desired point of variables to predict the output quantities as well as describing the process trend, while TOPSIS method is unable to predict the process trend and only provides the ranking of alternatives.
format	article
author	E Rahmati F Sharifian M Fattahi Gh Najafi
author_facet	E Rahmati F Sharifian M Fattahi Gh Najafi
author_sort	E Rahmati
title	Optimization the Spray-Drying Process of Moldavian Balm Plant Extract using Response Surface Methodology and TOPSIS Method
title_short	Optimization the Spray-Drying Process of Moldavian Balm Plant Extract using Response Surface Methodology and TOPSIS Method
title_full	Optimization the Spray-Drying Process of Moldavian Balm Plant Extract using Response Surface Methodology and TOPSIS Method
title_fullStr	Optimization the Spray-Drying Process of Moldavian Balm Plant Extract using Response Surface Methodology and TOPSIS Method
title_full_unstemmed	Optimization the Spray-Drying Process of Moldavian Balm Plant Extract using Response Surface Methodology and TOPSIS Method
title_sort	optimization the spray-drying process of moldavian balm plant extract using response surface methodology and topsis method
publisher	Ferdowsi University of Mashhad
publishDate	2020
url	https://doaj.org/article/adb140abdaf04519bf115564011251da
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spelling	oai:doaj.org-article:adb140abdaf04519bf115564011251da2021-11-14T06:35:26ZOptimization the Spray-Drying Process of Moldavian Balm Plant Extract using Response Surface Methodology and TOPSIS Method2228-68292423-394310.22067/jam.v10i2.78344https://doaj.org/article/adb140abdaf04519bf115564011251da2020-09-01T00:00:00Zhttps://jame.um.ac.ir/article_34248_993db918bf6f3f3319069b835d78288a.pdfhttps://doaj.org/toc/2228-6829https://doaj.org/toc/2423-3943Introduction Dracocephalum moldavica L. is an annual plant with blue or white flowers and fragrant leaves which belongs to the family of Lamiaceae with the height of up to 80 cm. This plant is native to Central Asia and is accepted in Central and Eastern Europe. In Iran, it is mainly grown in the province of West Azarbaijan and the Alborz Mountains. The essential oils and extracts derived from the secondary metabolisms which are mainly used in the pharmaceutical industry, dietary, cosmetic, flavoring and also as tea and beverage with sugar or honey. The liquid extract of the herb contains a high percentage of water, which should evaporate to increase shelf-life, easy transport, handling and storage, the ease of standardization and preservation of the product quality. On the other hand, the active compounds of the extracts are affected by temperature, oxygen, light and enzymes. Therefore, because of the uses and benefits of herbal extracts, they need to be dried by a practical and effective method like spray drying. In literature still there are no studies taking into account to the comparisons between RSM and TOPSIS as two important optimization methods. So, as the main objective of the present work, the effects of moisture content, drying performance, total phenol content, total flavonoid content and antioxidant activity have been surveyed. Finally, the optimal point of each process variable was presented by two optimization methods. Materials and Methods Aerial parts of Moldavian balm plant were cleaned and drying of plant was carried out under shade and thin layer conditions. The extraction of Moldavian balm was obtained by maceration method using ethanol 50 % (v/v), plant to solvent ratio of 1/10 (w/v). After 48h, the extract was concentrated in a rotary evaporator (Buchi Rotavapor R-205, Switzerland) to obtain a solid concentration of 6%. The used carrier was: Maltodextrin and apple pectin. Different ratios of carrier were prepared, then the ratio was added to distilled water and stirred by a magnetic stirrer. Finally, the solution was mixed with extract. The drying of Moldavian Balm plant extract was performed using a spray-dryer (Büchi B-191, Switzerland) with co-current flow regime. The powders provided by the spray drying were stored in refrigerator until they were needed for the experiment. Results and Discussion The results of variance analysis showed that the Box-Behnken design with the second-order model has led to the meaningfulness of the model, insignificant of the Lack of Fit and the appropriate correlation coefficient for each of the responses. A total number of 15 experiments were conducted to investigate the effect of process variables such as inlet air temperature, compressed air flow rate and concentration of carriers on moisture content, drying performance, total phenolic content, total flavonoid content and antioxidant activity of Moldavian balm powder. Inlet air temperature and compressed air flow rate had the most significant effect on moisture content and drying performance, while Chemical properties of the powder affected by changing the concentration of carriers. Optimization parameters of the spray drying process was performed using surface response and TOPSIS methods. The optimum predicted conditions in the response surface method and TOPSIS method were obtained at inlet air temperature, compressed air flow rate and concentration of carrier (152.5-150°C), (8.046-7.5 lit min-1) and 20%, respectively. Conclusions By comparing two methods, it can be concluded that although they could provide the same optimum points, the RSM is more efficient. Because RSM offers a mathematical model that can be used at any desired point of variables to predict the output quantities as well as describing the process trend, while TOPSIS method is unable to predict the process trend and only provides the ranking of alternatives.E RahmatiF SharifianM FattahiGh NajafiFerdowsi University of Mashhadarticleoptimizationspray-dryingtopsis methodrsm methoddrying conditionsmoldavian balm powderAgriculture (General)S1-972Engineering (General). Civil engineering (General)TA1-2040ENFAJournal of Agricultural Machinery, Vol 10, Iss 2, Pp 201-212 (2020)

Optimization the Spray-Drying Process of Moldavian Balm Plant Extract using Response Surface Methodology and TOPSIS Method

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