Prolonged carriage of ESBL-producing enterobacterales and potential cross-transmission among residents in geriatric long-term care facilities

Abstract Previous studies indicated residents in geriatric long-term care facilities (LTCFs) had much higher prevalence of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) carriage than the general population. Most ESBL-E carriers are asymptomatic. The study tested the hypothesis...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ryusuke Ae, Teppei Sasahara, Akio Yoshimura, Koki Kosami, Shuji Hatakeyama, Kazumasa Sasaki, Yumiko Kimura, Dai Akine, Masanori Ogawa, Kenji Hamabata, Longzhu Cui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/adb3b3e343184c619a10a040edfb2d77
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:adb3b3e343184c619a10a040edfb2d77
record_format	dspace
spelling	oai:doaj.org-article:adb3b3e343184c619a10a040edfb2d772021-11-08T10:52:18ZProlonged carriage of ESBL-producing enterobacterales and potential cross-transmission among residents in geriatric long-term care facilities10.1038/s41598-021-01190-w2045-2322https://doaj.org/article/adb3b3e343184c619a10a040edfb2d772021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01190-whttps://doaj.org/toc/2045-2322Abstract Previous studies indicated residents in geriatric long-term care facilities (LTCFs) had much higher prevalence of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) carriage than the general population. Most ESBL-E carriers are asymptomatic. The study tested the hypothesis that residents with ESBL-E carriage may accumulate inside geriatric LTCFs through potential cross-transmission after exposure to residents with prolonged ESBL-E carriage. 260 residents from four Japanese LTCFs underwent ESBL-E testing of fecal specimens and were divided into two cohorts: Cohort 1,75 patients with ≥ 2 months residence at study onset; Cohort 2, 185 patients with < 2 months residence at study onset or new admission during the study period. Three analyses were performed: (1) ESBL-E carriage statuses in Cohort 1 and Cohort 2; (2) changes in ESBL-E carriage statuses 3–12 months after the first testing and ≥ 12 months after the second testing; and (3) lengths of positive ESBL-E carriage statuses. Compared with the residents in Cohort 1, a significantly larger proportion of residents in Cohort 2 were positive for ESBL-E carriage (28.0% in Cohort 1 vs 40.0% in Cohort 2). In the subsequent testing results, 18.3% of residents who were negative in the first testing showed positive conversion to ESBL-E carriage in the second testing, while no patients who were negative in the second testing showed positive conversion in the third testing. The maximum length of ESBL-E carriage was 17 months. The findings indicated that some residents acquired ESBL-E through potential cross-transmission inside the LTCFs after short-term residence. However, no residents showed positive conversion after long-term residence, which indicates that residents with ESBL-E carriage may not accumulate inside LTCFs. Practical infection control and prevention measures could improve the ESBL-E prevalence in geriatric LTCFs.Ryusuke AeTeppei SasaharaAkio YoshimuraKoki KosamiShuji HatakeyamaKazumasa SasakiYumiko KimuraDai AkineMasanori OgawaKenji HamabataLongzhu CuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryusuke Ae Teppei Sasahara Akio Yoshimura Koki Kosami Shuji Hatakeyama Kazumasa Sasaki Yumiko Kimura Dai Akine Masanori Ogawa Kenji Hamabata Longzhu Cui Prolonged carriage of ESBL-producing enterobacterales and potential cross-transmission among residents in geriatric long-term care facilities
description	Abstract Previous studies indicated residents in geriatric long-term care facilities (LTCFs) had much higher prevalence of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) carriage than the general population. Most ESBL-E carriers are asymptomatic. The study tested the hypothesis that residents with ESBL-E carriage may accumulate inside geriatric LTCFs through potential cross-transmission after exposure to residents with prolonged ESBL-E carriage. 260 residents from four Japanese LTCFs underwent ESBL-E testing of fecal specimens and were divided into two cohorts: Cohort 1,75 patients with ≥ 2 months residence at study onset; Cohort 2, 185 patients with < 2 months residence at study onset or new admission during the study period. Three analyses were performed: (1) ESBL-E carriage statuses in Cohort 1 and Cohort 2; (2) changes in ESBL-E carriage statuses 3–12 months after the first testing and ≥ 12 months after the second testing; and (3) lengths of positive ESBL-E carriage statuses. Compared with the residents in Cohort 1, a significantly larger proportion of residents in Cohort 2 were positive for ESBL-E carriage (28.0% in Cohort 1 vs 40.0% in Cohort 2). In the subsequent testing results, 18.3% of residents who were negative in the first testing showed positive conversion to ESBL-E carriage in the second testing, while no patients who were negative in the second testing showed positive conversion in the third testing. The maximum length of ESBL-E carriage was 17 months. The findings indicated that some residents acquired ESBL-E through potential cross-transmission inside the LTCFs after short-term residence. However, no residents showed positive conversion after long-term residence, which indicates that residents with ESBL-E carriage may not accumulate inside LTCFs. Practical infection control and prevention measures could improve the ESBL-E prevalence in geriatric LTCFs.
format	article
author	Ryusuke Ae Teppei Sasahara Akio Yoshimura Koki Kosami Shuji Hatakeyama Kazumasa Sasaki Yumiko Kimura Dai Akine Masanori Ogawa Kenji Hamabata Longzhu Cui
author_facet	Ryusuke Ae Teppei Sasahara Akio Yoshimura Koki Kosami Shuji Hatakeyama Kazumasa Sasaki Yumiko Kimura Dai Akine Masanori Ogawa Kenji Hamabata Longzhu Cui
author_sort	Ryusuke Ae
title	Prolonged carriage of ESBL-producing enterobacterales and potential cross-transmission among residents in geriatric long-term care facilities
title_short	Prolonged carriage of ESBL-producing enterobacterales and potential cross-transmission among residents in geriatric long-term care facilities
title_full	Prolonged carriage of ESBL-producing enterobacterales and potential cross-transmission among residents in geriatric long-term care facilities
title_fullStr	Prolonged carriage of ESBL-producing enterobacterales and potential cross-transmission among residents in geriatric long-term care facilities
title_full_unstemmed	Prolonged carriage of ESBL-producing enterobacterales and potential cross-transmission among residents in geriatric long-term care facilities
title_sort	prolonged carriage of esbl-producing enterobacterales and potential cross-transmission among residents in geriatric long-term care facilities
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/adb3b3e343184c619a10a040edfb2d77
work_keys_str_mv	AT ryusukeae prolongedcarriageofesblproducingenterobacteralesandpotentialcrosstransmissionamongresidentsingeriatriclongtermcarefacilities AT teppeisasahara prolongedcarriageofesblproducingenterobacteralesandpotentialcrosstransmissionamongresidentsingeriatriclongtermcarefacilities AT akioyoshimura prolongedcarriageofesblproducingenterobacteralesandpotentialcrosstransmissionamongresidentsingeriatriclongtermcarefacilities AT kokikosami prolongedcarriageofesblproducingenterobacteralesandpotentialcrosstransmissionamongresidentsingeriatriclongtermcarefacilities AT shujihatakeyama prolongedcarriageofesblproducingenterobacteralesandpotentialcrosstransmissionamongresidentsingeriatriclongtermcarefacilities AT kazumasasasaki prolongedcarriageofesblproducingenterobacteralesandpotentialcrosstransmissionamongresidentsingeriatriclongtermcarefacilities AT yumikokimura prolongedcarriageofesblproducingenterobacteralesandpotentialcrosstransmissionamongresidentsingeriatriclongtermcarefacilities AT daiakine prolongedcarriageofesblproducingenterobacteralesandpotentialcrosstransmissionamongresidentsingeriatriclongtermcarefacilities AT masanoriogawa prolongedcarriageofesblproducingenterobacteralesandpotentialcrosstransmissionamongresidentsingeriatriclongtermcarefacilities AT kenjihamabata prolongedcarriageofesblproducingenterobacteralesandpotentialcrosstransmissionamongresidentsingeriatriclongtermcarefacilities AT longzhucui prolongedcarriageofesblproducingenterobacteralesandpotentialcrosstransmissionamongresidentsingeriatriclongtermcarefacilities
_version_	1718442557607772160

Prolonged carriage of ESBL-producing enterobacterales and potential cross-transmission among residents in geriatric long-term care facilities

Ejemplares similares