New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants

The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational simulations in combination with scale-down experim...

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Autores principales:	Thierry Furrer, Benedikt Müller, Christoph Hasler, Bernhard Berger, Michael K. Levis, Andreas Zogg
Formato:	article
Lenguaje:	DE EN FR
Publicado:	Swiss Chemical Society 2021
Materias:	agitated vessel hydrogenation process modelling quality by design (qbd) scale-up / scale-down Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/adb47e6580514b6f905cd4df21c8f1c4
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id	oai:doaj.org-article:adb47e6580514b6f905cd4df21c8f1c4
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spelling	oai:doaj.org-article:adb47e6580514b6f905cd4df21c8f1c42021-11-26T10:08:51ZNew Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants10.2533/chimia.2021.9480009-42932673-2424https://doaj.org/article/adb47e6580514b6f905cd4df21c8f1c42021-11-01T00:00:00Zhttps://doaj.org/toc/0009-4293https://doaj.org/toc/2673-2424The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational simulations in combination with scale-down experiments. With only a few laboratory-scale experiments and information about the production-scale reactor, a chemical process model is developed. This computational model can be used to simulate the production-scale process with a range of different process parameters. Those simulations are then validated by only a few experiments in an advanced scale-down reactor. The scale-down reactor has to be geometrically identical to the corresponding production-scale reactor and should show a similar mass transfer behaviour. Closest similarity in terms of heat transfer behaviour is ensured by a sophisticated 3D-printed heating/cooling finger, offering the same heat exchange area per volume and overall heat-transfer coefficient as in production-scale. The proposed scale-up strategy and the custom-designed scale-down reactor will be tested by proof of concept with model reactions. Those results will be described in a future publication. This project is an excellent example of a collaboration between academia and industry, which was funded by the Aargau Research Fund. The interest of academia is to study and understand all physical and chemical processes involved, whereas industry is interested in generating a robust and simple to use tool to improve scale-up and make reliable predictions.Thierry FurrerBenedikt MüllerChristoph HaslerBernhard BergerMichael K. LevisAndreas ZoggSwiss Chemical Societyarticleagitated vesselhydrogenationprocess modellingquality by design (qbd)scale-up / scale-downChemistryQD1-999DEENFRCHIMIA, Vol 75, Iss 11, Pp 948-956 (2021)
institution	DOAJ
collection	DOAJ
language	DE EN FR
topic	agitated vessel hydrogenation process modelling quality by design (qbd) scale-up / scale-down Chemistry QD1-999
spellingShingle	agitated vessel hydrogenation process modelling quality by design (qbd) scale-up / scale-down Chemistry QD1-999 Thierry Furrer Benedikt Müller Christoph Hasler Bernhard Berger Michael K. Levis Andreas Zogg New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants
description	The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational simulations in combination with scale-down experiments. With only a few laboratory-scale experiments and information about the production-scale reactor, a chemical process model is developed. This computational model can be used to simulate the production-scale process with a range of different process parameters. Those simulations are then validated by only a few experiments in an advanced scale-down reactor. The scale-down reactor has to be geometrically identical to the corresponding production-scale reactor and should show a similar mass transfer behaviour. Closest similarity in terms of heat transfer behaviour is ensured by a sophisticated 3D-printed heating/cooling finger, offering the same heat exchange area per volume and overall heat-transfer coefficient as in production-scale. The proposed scale-up strategy and the custom-designed scale-down reactor will be tested by proof of concept with model reactions. Those results will be described in a future publication. This project is an excellent example of a collaboration between academia and industry, which was funded by the Aargau Research Fund. The interest of academia is to study and understand all physical and chemical processes involved, whereas industry is interested in generating a robust and simple to use tool to improve scale-up and make reliable predictions.
format	article
author	Thierry Furrer Benedikt Müller Christoph Hasler Bernhard Berger Michael K. Levis Andreas Zogg
author_facet	Thierry Furrer Benedikt Müller Christoph Hasler Bernhard Berger Michael K. Levis Andreas Zogg
author_sort	Thierry Furrer
title	New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants
title_short	New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants
title_full	New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants
title_fullStr	New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants
title_full_unstemmed	New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants
title_sort	new scale-up technologies for hydrogenation reactions in multipurpose pharmaceutical production plants
publisher	Swiss Chemical Society
publishDate	2021
url	https://doaj.org/article/adb47e6580514b6f905cd4df21c8f1c4
work_keys_str_mv	AT thierryfurrer newscaleuptechnologiesforhydrogenationreactionsinmultipurposepharmaceuticalproductionplants AT benediktmuller newscaleuptechnologiesforhydrogenationreactionsinmultipurposepharmaceuticalproductionplants AT christophhasler newscaleuptechnologiesforhydrogenationreactionsinmultipurposepharmaceuticalproductionplants AT bernhardberger newscaleuptechnologiesforhydrogenationreactionsinmultipurposepharmaceuticalproductionplants AT michaelklevis newscaleuptechnologiesforhydrogenationreactionsinmultipurposepharmaceuticalproductionplants AT andreaszogg newscaleuptechnologiesforhydrogenationreactionsinmultipurposepharmaceuticalproductionplants
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New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants

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