Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

Lactobacillus plantarum ZJUFB2 is a novel probiotic isolate derived from Chinese traditional sourdough that possesses promising probiotics properties. This study aimed to investigate the effects of L. plantarum ZJUFB2 (B2) on insulin sensitivity using mice fed on a high-fat diet (HFD) as well as to...

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Autores principales:	Hao Zhong, Jian Wang, Abdullah, Muhammad Adnan Hafeez, Rongfa Guan, Fengqin Feng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Lactobacillus plantarum metabolic syndrome insulin resistance gut microbiota bile acids Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/adb60e92de6f4ea9be30e05f2b4fdd13
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spelling	oai:doaj.org-article:adb60e92de6f4ea9be30e05f2b4fdd132021-11-05T17:24:15ZLactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota2296-861X10.3389/fnut.2021.754222https://doaj.org/article/adb60e92de6f4ea9be30e05f2b4fdd132021-10-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.754222/fullhttps://doaj.org/toc/2296-861XLactobacillus plantarum ZJUFB2 is a novel probiotic isolate derived from Chinese traditional sourdough that possesses promising probiotics properties. This study aimed to investigate the effects of L. plantarum ZJUFB2 (B2) on insulin sensitivity using mice fed on a high-fat diet (HFD) as well as to explore the involved mechanisms. Purposely, male C57BL/6 mice continuously received an intervention of B2 (~109 CFU/day) for 16 weeks. The results showed that B2 treatment remarkably ameliorated insulin resistance and hyperglycemia in HFD-fed mice. The B2 intervention significantly decreased the hepatic lipid accumulation, serum low-density lipoproteins cholesterol, and lipopolysaccharides, and regulated the bile acids levels as well as liver mRNA expression involved in lipid metabolism. Moreover, the B2 intervention significantly changed the gut microbiota, specifically, showed a lower abundance of obesity-related and inflammation-associated microbes, e.g., Ruminococcus and Mogibacteriaceae. Furthermore, it exhibited a higher abundance of short-chain fatty acids and bile salt hydrolas-producing bacteria, such as Bifidobacterium and F16 compared with the HFD group. The findings of this study suggested that B2 is a novel probiotic, effective in preventing insulin resistance by improving the gut microbiota and bile acids.Hao ZhongJian Wang AbdullahMuhammad Adnan HafeezRongfa GuanFengqin FengFrontiers Media S.A.articleLactobacillus plantarummetabolic syndromeinsulin resistancegut microbiotabile acidsNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lactobacillus plantarum metabolic syndrome insulin resistance gut microbiota bile acids Nutrition. Foods and food supply TX341-641
spellingShingle	Lactobacillus plantarum metabolic syndrome insulin resistance gut microbiota bile acids Nutrition. Foods and food supply TX341-641 Hao Zhong Jian Wang Abdullah Muhammad Adnan Hafeez Rongfa Guan Fengqin Feng Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota
description	Lactobacillus plantarum ZJUFB2 is a novel probiotic isolate derived from Chinese traditional sourdough that possesses promising probiotics properties. This study aimed to investigate the effects of L. plantarum ZJUFB2 (B2) on insulin sensitivity using mice fed on a high-fat diet (HFD) as well as to explore the involved mechanisms. Purposely, male C57BL/6 mice continuously received an intervention of B2 (~109 CFU/day) for 16 weeks. The results showed that B2 treatment remarkably ameliorated insulin resistance and hyperglycemia in HFD-fed mice. The B2 intervention significantly decreased the hepatic lipid accumulation, serum low-density lipoproteins cholesterol, and lipopolysaccharides, and regulated the bile acids levels as well as liver mRNA expression involved in lipid metabolism. Moreover, the B2 intervention significantly changed the gut microbiota, specifically, showed a lower abundance of obesity-related and inflammation-associated microbes, e.g., Ruminococcus and Mogibacteriaceae. Furthermore, it exhibited a higher abundance of short-chain fatty acids and bile salt hydrolas-producing bacteria, such as Bifidobacterium and F16 compared with the HFD group. The findings of this study suggested that B2 is a novel probiotic, effective in preventing insulin resistance by improving the gut microbiota and bile acids.
format	article
author	Hao Zhong Jian Wang Abdullah Muhammad Adnan Hafeez Rongfa Guan Fengqin Feng
author_facet	Hao Zhong Jian Wang Abdullah Muhammad Adnan Hafeez Rongfa Guan Fengqin Feng
author_sort	Hao Zhong
title	Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota
title_short	Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota
title_full	Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota
title_fullStr	Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota
title_full_unstemmed	Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota
title_sort	lactobacillus plantarum zjufb2 prevents high fat diet-induced insulin resistance in association with modulation of the gut microbiota
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/adb60e92de6f4ea9be30e05f2b4fdd13
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Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

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