Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage

Knowledge of genomic features specific to humans may be important for understanding disease. Here the authors demonstrate a potential role for these human-lineage-specific sequences in brain development and neurological disease.

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Autores principales:	Zhongbo Chen, David Zhang, Regina H. Reynolds, Emil K. Gustavsson, Sonia García-Ruiz, Karishma D’Sa, Aine Fairbrother-Browne, Jana Vandrovcova, International Parkinson’s Disease Genomics Consortium (IPDGC), John Hardy, Henry Houlden, Sarah A. Gagliano Taliun, Juan Botía, Mina Ryten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/adb7017084874dddbf672c99a5595752
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spelling	oai:doaj.org-article:adb7017084874dddbf672c99a55957522021-12-02T14:21:15ZHuman-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage10.1038/s41467-021-22262-52041-1723https://doaj.org/article/adb7017084874dddbf672c99a55957522021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22262-5https://doaj.org/toc/2041-1723Knowledge of genomic features specific to humans may be important for understanding disease. Here the authors demonstrate a potential role for these human-lineage-specific sequences in brain development and neurological disease.Zhongbo ChenDavid ZhangRegina H. ReynoldsEmil K. GustavssonSonia García-RuizKarishma D’SaAine Fairbrother-BrowneJana VandrovcovaInternational Parkinson’s Disease Genomics Consortium (IPDGC)John HardyHenry HouldenSarah A. Gagliano TaliunJuan BotíaMina RytenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhongbo Chen David Zhang Regina H. Reynolds Emil K. Gustavsson Sonia García-Ruiz Karishma D’Sa Aine Fairbrother-Browne Jana Vandrovcova International Parkinson’s Disease Genomics Consortium (IPDGC) John Hardy Henry Houlden Sarah A. Gagliano Taliun Juan Botía Mina Ryten Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage
description	Knowledge of genomic features specific to humans may be important for understanding disease. Here the authors demonstrate a potential role for these human-lineage-specific sequences in brain development and neurological disease.
format	article
author	Zhongbo Chen David Zhang Regina H. Reynolds Emil K. Gustavsson Sonia García-Ruiz Karishma D’Sa Aine Fairbrother-Browne Jana Vandrovcova International Parkinson’s Disease Genomics Consortium (IPDGC) John Hardy Henry Houlden Sarah A. Gagliano Taliun Juan Botía Mina Ryten
author_facet	Zhongbo Chen David Zhang Regina H. Reynolds Emil K. Gustavsson Sonia García-Ruiz Karishma D’Sa Aine Fairbrother-Browne Jana Vandrovcova International Parkinson’s Disease Genomics Consortium (IPDGC) John Hardy Henry Houlden Sarah A. Gagliano Taliun Juan Botía Mina Ryten
author_sort	Zhongbo Chen
title	Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage
title_short	Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage
title_full	Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage
title_fullStr	Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage
title_full_unstemmed	Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage
title_sort	human-lineage-specific genomic elements are associated with neurodegenerative disease and apoe transcript usage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/adb7017084874dddbf672c99a5595752
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Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage

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