The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnologic...

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Autores principales:	Ana Gomes, Luísa Aguiar, Ricardo Ferraz, Cátia Teixeira, Paula Gomes
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	active pharmaceutical ingredients complicated skin and soft tissue infections cosmetics ionic liquids peptides transdermal delivery Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/adb9d6ab30ed474c8c02fa3267d85aab
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spelling	oai:doaj.org-article:adb9d6ab30ed474c8c02fa3267d85aab2021-11-11T17:25:08ZThe Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years10.3390/ijms2221119911422-00671661-6596https://doaj.org/article/adb9d6ab30ed474c8c02fa3267d85aab2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11991https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.Ana GomesLuísa AguiarRicardo FerrazCátia TeixeiraPaula GomesMDPI AGarticleactive pharmaceutical ingredientscomplicated skin and soft tissue infectionscosmeticsionic liquidspeptidestransdermal deliveryBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11991, p 11991 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	active pharmaceutical ingredients complicated skin and soft tissue infections cosmetics ionic liquids peptides transdermal delivery Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	active pharmaceutical ingredients complicated skin and soft tissue infections cosmetics ionic liquids peptides transdermal delivery Biology (General) QH301-705.5 Chemistry QD1-999 Ana Gomes Luísa Aguiar Ricardo Ferraz Cátia Teixeira Paula Gomes The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years
description	Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.
format	article
author	Ana Gomes Luísa Aguiar Ricardo Ferraz Cátia Teixeira Paula Gomes
author_facet	Ana Gomes Luísa Aguiar Ricardo Ferraz Cátia Teixeira Paula Gomes
author_sort	Ana Gomes
title	The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years
title_short	The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years
title_full	The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years
title_fullStr	The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years
title_full_unstemmed	The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years
title_sort	emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/adb9d6ab30ed474c8c02fa3267d85aab
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The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

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