GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor

Abstract Exendin-4 is a long acting glucagon-like peptide 1 (GLP-1) analogue that is an agonist for the GLP-1 receptor, a G-protein coupled receptor (GPCR). Exendin-4 is used to clinically improve glucose tolerance in diabetic patients due to its ability to enhance insulin secretion. In rodents, and...

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Autores principales:	Joseph Fusco, Xiangwei Xiao, Krishna Prasadan, Qingfeng Sheng, Congde Chen, Yung-Ching Ming, George Gittes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/adbf0b4c28d74aa08e9ef0b15bfa14d9
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spelling	oai:doaj.org-article:adbf0b4c28d74aa08e9ef0b15bfa14d92021-12-02T11:51:13ZGLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor10.1038/s41598-017-09898-42045-2322https://doaj.org/article/adbf0b4c28d74aa08e9ef0b15bfa14d92017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09898-4https://doaj.org/toc/2045-2322Abstract Exendin-4 is a long acting glucagon-like peptide 1 (GLP-1) analogue that is an agonist for the GLP-1 receptor, a G-protein coupled receptor (GPCR). Exendin-4 is used to clinically improve glucose tolerance in diabetic patients due to its ability to enhance insulin secretion. In rodents, and possibly in humans, exendin-4 can stimulate β-cell proliferation. The exact mechanism of action to induce β-cell proliferation is not well understood. Here, using a β-cell specific epidermal growth factor receptor (EGFR) null mouse, we show that exendin-4 induced an increase in proliferation and β-cell mass through EGFR. Thus, our study sheds light on the role of EGFR signaling in the effects of exendin-4 on the control of blood glucose metabolism and β-cell mass.Joseph FuscoXiangwei XiaoKrishna PrasadanQingfeng ShengCongde ChenYung-Ching MingGeorge GittesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph Fusco Xiangwei Xiao Krishna Prasadan Qingfeng Sheng Congde Chen Yung-Ching Ming George Gittes GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor
description	Abstract Exendin-4 is a long acting glucagon-like peptide 1 (GLP-1) analogue that is an agonist for the GLP-1 receptor, a G-protein coupled receptor (GPCR). Exendin-4 is used to clinically improve glucose tolerance in diabetic patients due to its ability to enhance insulin secretion. In rodents, and possibly in humans, exendin-4 can stimulate β-cell proliferation. The exact mechanism of action to induce β-cell proliferation is not well understood. Here, using a β-cell specific epidermal growth factor receptor (EGFR) null mouse, we show that exendin-4 induced an increase in proliferation and β-cell mass through EGFR. Thus, our study sheds light on the role of EGFR signaling in the effects of exendin-4 on the control of blood glucose metabolism and β-cell mass.
format	article
author	Joseph Fusco Xiangwei Xiao Krishna Prasadan Qingfeng Sheng Congde Chen Yung-Ching Ming George Gittes
author_facet	Joseph Fusco Xiangwei Xiao Krishna Prasadan Qingfeng Sheng Congde Chen Yung-Ching Ming George Gittes
author_sort	Joseph Fusco
title	GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor
title_short	GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor
title_full	GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor
title_fullStr	GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor
title_full_unstemmed	GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor
title_sort	glp-1/exendin-4 induces β-cell proliferation via the epidermal growth factor receptor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/adbf0b4c28d74aa08e9ef0b15bfa14d9
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GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor

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