Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults

Abstract Cocoa flavanols protect humans against vascular disease, as evidenced by improvements in peripheral endothelial function, likely through nitric oxide signalling. Emerging evidence also suggests that flavanol-rich diets protect against cognitive aging, but mechanisms remain elusive. In a ran...

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Autores principales:	Gabriele Gratton, Samuel R. Weaver, Claire V. Burley, Kathy A. Low, Edward L. Maclin, Paul W. Johns, Quang S. Pham, Samuel J. E. Lucas, Monica Fabiani, Catarina Rendeiro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/adc806851d454f9ebddaaa32ffbb9e74
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spelling	oai:doaj.org-article:adc806851d454f9ebddaaa32ffbb9e742021-12-02T16:08:37ZDietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults10.1038/s41598-020-76160-92045-2322https://doaj.org/article/adc806851d454f9ebddaaa32ffbb9e742020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-76160-9https://doaj.org/toc/2045-2322Abstract Cocoa flavanols protect humans against vascular disease, as evidenced by improvements in peripheral endothelial function, likely through nitric oxide signalling. Emerging evidence also suggests that flavanol-rich diets protect against cognitive aging, but mechanisms remain elusive. In a randomized double-blind within-subject acute study in healthy young adults, we link these two lines of research by showing, for the first time, that flavanol intake leads to faster and greater brain oxygenation responses to hypercapnia, as well as higher performance only when cognitive demand is high. Individual difference analyses further show that participants who benefit from flavanols intake during hypercapnia are also those who do so in the cognitive challenge. These data support the hypothesis that similar vascular mechanisms underlie both the peripheral and cerebral effects of flavanols. They further show the importance of studies combining physiological and graded cognitive challenges in young adults to investigate the actions of dietary flavanols on brain function.Gabriele GrattonSamuel R. WeaverClaire V. BurleyKathy A. LowEdward L. MaclinPaul W. JohnsQuang S. PhamSamuel J. E. LucasMonica FabianiCatarina RendeiroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gabriele Gratton Samuel R. Weaver Claire V. Burley Kathy A. Low Edward L. Maclin Paul W. Johns Quang S. Pham Samuel J. E. Lucas Monica Fabiani Catarina Rendeiro Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults
description	Abstract Cocoa flavanols protect humans against vascular disease, as evidenced by improvements in peripheral endothelial function, likely through nitric oxide signalling. Emerging evidence also suggests that flavanol-rich diets protect against cognitive aging, but mechanisms remain elusive. In a randomized double-blind within-subject acute study in healthy young adults, we link these two lines of research by showing, for the first time, that flavanol intake leads to faster and greater brain oxygenation responses to hypercapnia, as well as higher performance only when cognitive demand is high. Individual difference analyses further show that participants who benefit from flavanols intake during hypercapnia are also those who do so in the cognitive challenge. These data support the hypothesis that similar vascular mechanisms underlie both the peripheral and cerebral effects of flavanols. They further show the importance of studies combining physiological and graded cognitive challenges in young adults to investigate the actions of dietary flavanols on brain function.
format	article
author	Gabriele Gratton Samuel R. Weaver Claire V. Burley Kathy A. Low Edward L. Maclin Paul W. Johns Quang S. Pham Samuel J. E. Lucas Monica Fabiani Catarina Rendeiro
author_facet	Gabriele Gratton Samuel R. Weaver Claire V. Burley Kathy A. Low Edward L. Maclin Paul W. Johns Quang S. Pham Samuel J. E. Lucas Monica Fabiani Catarina Rendeiro
author_sort	Gabriele Gratton
title	Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults
title_short	Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults
title_full	Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults
title_fullStr	Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults
title_full_unstemmed	Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults
title_sort	dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/adc806851d454f9ebddaaa32ffbb9e74
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Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults

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