Simulation study on the effects of cancellous bone structure in the skull on ultrasonic wave propagation

Abstract The transcranial Doppler method (TCD) enables the measurement of cerebral blood flow velocity and detection of emboli by applying an ultrasound probe to the temporal bone window, or the orbital or greater occipital foramina. TCD is widely used for evaluation of cerebral vasospasm after suba...

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Autores principales:	Itsuki Michimoto, Kazuki Miyashita, Hidehisa Suzuyama, Keita Yano, Yasuyo Kobayashi, Kozue Saito, Mami Matsukawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/adc807357a7c483a8a2839aa86086acb
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spelling	oai:doaj.org-article:adc807357a7c483a8a2839aa86086acb2021-12-02T17:51:21ZSimulation study on the effects of cancellous bone structure in the skull on ultrasonic wave propagation10.1038/s41598-021-96502-52045-2322https://doaj.org/article/adc807357a7c483a8a2839aa86086acb2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96502-5https://doaj.org/toc/2045-2322Abstract The transcranial Doppler method (TCD) enables the measurement of cerebral blood flow velocity and detection of emboli by applying an ultrasound probe to the temporal bone window, or the orbital or greater occipital foramina. TCD is widely used for evaluation of cerebral vasospasm after subarachnoid hemorrhage, early detection of patients with arterial stenosis, and the assessment of brain death. However, measurements often become difficult in older women. Among various factors contributing to this problem, we focused on the effect of the diploe in the skull bone on the penetration of ultrasound into the brain. In particular, the effect of the cancellous bone structure in the diploe was investigated. Using a 2D digital bone model, wave propagation through the skull bone was investigated using the finite-difference time-domain (FDTD) method. We fabricated digital bone models with similar structure but different BV/TV (bone volume/total volume) values in the diploe. At a BV/TV of approximately 50–60% (similar to that of older women), the minimum ultrasound amplitude was observed as a result of scattering and multiple reflections in the cancellous diploe. These results suggest that structural changes such as osteoporosis may be one factor hampering TCD measurements.Itsuki MichimotoKazuki MiyashitaHidehisa SuzuyamaKeita YanoYasuyo KobayashiKozue SaitoMami MatsukawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Itsuki Michimoto Kazuki Miyashita Hidehisa Suzuyama Keita Yano Yasuyo Kobayashi Kozue Saito Mami Matsukawa Simulation study on the effects of cancellous bone structure in the skull on ultrasonic wave propagation
description	Abstract The transcranial Doppler method (TCD) enables the measurement of cerebral blood flow velocity and detection of emboli by applying an ultrasound probe to the temporal bone window, or the orbital or greater occipital foramina. TCD is widely used for evaluation of cerebral vasospasm after subarachnoid hemorrhage, early detection of patients with arterial stenosis, and the assessment of brain death. However, measurements often become difficult in older women. Among various factors contributing to this problem, we focused on the effect of the diploe in the skull bone on the penetration of ultrasound into the brain. In particular, the effect of the cancellous bone structure in the diploe was investigated. Using a 2D digital bone model, wave propagation through the skull bone was investigated using the finite-difference time-domain (FDTD) method. We fabricated digital bone models with similar structure but different BV/TV (bone volume/total volume) values in the diploe. At a BV/TV of approximately 50–60% (similar to that of older women), the minimum ultrasound amplitude was observed as a result of scattering and multiple reflections in the cancellous diploe. These results suggest that structural changes such as osteoporosis may be one factor hampering TCD measurements.
format	article
author	Itsuki Michimoto Kazuki Miyashita Hidehisa Suzuyama Keita Yano Yasuyo Kobayashi Kozue Saito Mami Matsukawa
author_facet	Itsuki Michimoto Kazuki Miyashita Hidehisa Suzuyama Keita Yano Yasuyo Kobayashi Kozue Saito Mami Matsukawa
author_sort	Itsuki Michimoto
title	Simulation study on the effects of cancellous bone structure in the skull on ultrasonic wave propagation
title_short	Simulation study on the effects of cancellous bone structure in the skull on ultrasonic wave propagation
title_full	Simulation study on the effects of cancellous bone structure in the skull on ultrasonic wave propagation
title_fullStr	Simulation study on the effects of cancellous bone structure in the skull on ultrasonic wave propagation
title_full_unstemmed	Simulation study on the effects of cancellous bone structure in the skull on ultrasonic wave propagation
title_sort	simulation study on the effects of cancellous bone structure in the skull on ultrasonic wave propagation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/adc807357a7c483a8a2839aa86086acb
work_keys_str_mv	AT itsukimichimoto simulationstudyontheeffectsofcancellousbonestructureintheskullonultrasonicwavepropagation AT kazukimiyashita simulationstudyontheeffectsofcancellousbonestructureintheskullonultrasonicwavepropagation AT hidehisasuzuyama simulationstudyontheeffectsofcancellousbonestructureintheskullonultrasonicwavepropagation AT keitayano simulationstudyontheeffectsofcancellousbonestructureintheskullonultrasonicwavepropagation AT yasuyokobayashi simulationstudyontheeffectsofcancellousbonestructureintheskullonultrasonicwavepropagation AT kozuesaito simulationstudyontheeffectsofcancellousbonestructureintheskullonultrasonicwavepropagation AT mamimatsukawa simulationstudyontheeffectsofcancellousbonestructureintheskullonultrasonicwavepropagation
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Simulation study on the effects of cancellous bone structure in the skull on ultrasonic wave propagation

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