Downregulation of blood serum microRNA 29 family in patients with Parkinson’s disease

Abstract There is currently no reliable and easily applicable diagnostic marker for Parkinson’s disease (PD). The aims of the present study were to compare the expression profiles of the microRNA29 family (miR-29s) in blood serum from patients with PD with healthy controls and to clarify whether the...

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Autores principales:	Xiaochen Bai, Yilin Tang, Mei Yu, Lei Wu, Fengtao Liu, Jianliang Ni, Zishan Wang, Jinghui Wang, Jian Fei, Wei Wang, Fang Huang, Jian Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/adcb7482eb524f7baf6de7cf27292178
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spelling	oai:doaj.org-article:adcb7482eb524f7baf6de7cf272921782021-12-02T12:32:38ZDownregulation of blood serum microRNA 29 family in patients with Parkinson’s disease10.1038/s41598-017-03887-32045-2322https://doaj.org/article/adcb7482eb524f7baf6de7cf272921782017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03887-3https://doaj.org/toc/2045-2322Abstract There is currently no reliable and easily applicable diagnostic marker for Parkinson’s disease (PD). The aims of the present study were to compare the expression profiles of the microRNA29 family (miR-29s) in blood serum from patients with PD with healthy controls and to clarify whether the expression of miR-29s is correlated with disease severity, duration or L-dopa therapy and whether expression depends on the gender and age of patients. The levels of blood serum miR-29s in 80 patients with PD and 80 unaffected controls were assessed by reverse transcription-quantitative real-time PCR. The PCR products were confirmed by cloning and sequencing. Additionally, the expression of miR-7 in the blood serum from PD patients and control subjects was assessed. Serum miR-29 levels were significantly downregulated in PD patients compared to healthy controls. The serum miR-29 levels in female PD patients were markedly higher than in male PD patients. The expression of serum miR-29a and miR-29c expression tended to decrease with disease severity. Moreover, we found that serum miR-7 levels did not differ between PD patients and control subjects. Therefore, the reduction of serum miR-29 levels, particularly miR-29a and miR-29c, warrants further investigation of its potential serving as biomarkers for PD.Xiaochen BaiYilin TangMei YuLei WuFengtao LiuJianliang NiZishan WangJinghui WangJian FeiWei WangFang HuangJian WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaochen Bai Yilin Tang Mei Yu Lei Wu Fengtao Liu Jianliang Ni Zishan Wang Jinghui Wang Jian Fei Wei Wang Fang Huang Jian Wang Downregulation of blood serum microRNA 29 family in patients with Parkinson’s disease
description	Abstract There is currently no reliable and easily applicable diagnostic marker for Parkinson’s disease (PD). The aims of the present study were to compare the expression profiles of the microRNA29 family (miR-29s) in blood serum from patients with PD with healthy controls and to clarify whether the expression of miR-29s is correlated with disease severity, duration or L-dopa therapy and whether expression depends on the gender and age of patients. The levels of blood serum miR-29s in 80 patients with PD and 80 unaffected controls were assessed by reverse transcription-quantitative real-time PCR. The PCR products were confirmed by cloning and sequencing. Additionally, the expression of miR-7 in the blood serum from PD patients and control subjects was assessed. Serum miR-29 levels were significantly downregulated in PD patients compared to healthy controls. The serum miR-29 levels in female PD patients were markedly higher than in male PD patients. The expression of serum miR-29a and miR-29c expression tended to decrease with disease severity. Moreover, we found that serum miR-7 levels did not differ between PD patients and control subjects. Therefore, the reduction of serum miR-29 levels, particularly miR-29a and miR-29c, warrants further investigation of its potential serving as biomarkers for PD.
format	article
author	Xiaochen Bai Yilin Tang Mei Yu Lei Wu Fengtao Liu Jianliang Ni Zishan Wang Jinghui Wang Jian Fei Wei Wang Fang Huang Jian Wang
author_facet	Xiaochen Bai Yilin Tang Mei Yu Lei Wu Fengtao Liu Jianliang Ni Zishan Wang Jinghui Wang Jian Fei Wei Wang Fang Huang Jian Wang
author_sort	Xiaochen Bai
title	Downregulation of blood serum microRNA 29 family in patients with Parkinson’s disease
title_short	Downregulation of blood serum microRNA 29 family in patients with Parkinson’s disease
title_full	Downregulation of blood serum microRNA 29 family in patients with Parkinson’s disease
title_fullStr	Downregulation of blood serum microRNA 29 family in patients with Parkinson’s disease
title_full_unstemmed	Downregulation of blood serum microRNA 29 family in patients with Parkinson’s disease
title_sort	downregulation of blood serum microrna 29 family in patients with parkinson’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/adcb7482eb524f7baf6de7cf27292178
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Downregulation of blood serum microRNA 29 family in patients with Parkinson’s disease

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