Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression

Mitochondrial redox metabolism is the central component in the cellular metabolic landscape, where anabolic and catabolic pathways are reprogrammed to maintain optimum redox homeostasis. During different stages of cancer, the mitochondrial redox status plays an active role in navigating cancer cells...

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Autor principal:	Feroza K. Choudhury
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mitochondrial redox metabolism ROS signaling tumor development metastasis distant colonization Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/adcb86488fbf411dbf004e7490036060
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spelling	oai:doaj.org-article:adcb86488fbf411dbf004e74900360602021-11-25T16:29:37ZMitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression10.3390/antiox101118382076-3921https://doaj.org/article/adcb86488fbf411dbf004e74900360602021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1838https://doaj.org/toc/2076-3921Mitochondrial redox metabolism is the central component in the cellular metabolic landscape, where anabolic and catabolic pathways are reprogrammed to maintain optimum redox homeostasis. During different stages of cancer, the mitochondrial redox status plays an active role in navigating cancer cells’ progression and regulating metabolic adaptation according to the constraints of each stage. Mitochondrial reactive oxygen species (ROS) accumulation induces malignant transformation. Once vigorous cell proliferation renders the core of the solid tumor hypoxic, the mitochondrial electron transport chain mediates ROS signaling for bringing about cellular adaptation to hypoxia. Highly aggressive cells are selected in this process, which are capable of progressing through the enhanced oxidative stress encountered during different stages of metastasis for distant colonization. Mitochondrial oxidative metabolism is suppressed to lower ROS generation, and the overall cellular metabolism is reprogrammed to maintain the optimum NADPH level in the mitochondria required for redox homeostasis. After reaching the distant organ, the intrinsic metabolic limitations of that organ dictate the success of colonization and flexibility of the mitochondrial metabolism of cancer cells plays a pivotal role in their adaptation to the new environment.Feroza K. ChoudhuryMDPI AGarticlemitochondrial redox metabolismROS signalingtumor developmentmetastasisdistant colonizationTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1838, p 1838 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondrial redox metabolism ROS signaling tumor development metastasis distant colonization Therapeutics. Pharmacology RM1-950
spellingShingle	mitochondrial redox metabolism ROS signaling tumor development metastasis distant colonization Therapeutics. Pharmacology RM1-950 Feroza K. Choudhury Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression
description	Mitochondrial redox metabolism is the central component in the cellular metabolic landscape, where anabolic and catabolic pathways are reprogrammed to maintain optimum redox homeostasis. During different stages of cancer, the mitochondrial redox status plays an active role in navigating cancer cells’ progression and regulating metabolic adaptation according to the constraints of each stage. Mitochondrial reactive oxygen species (ROS) accumulation induces malignant transformation. Once vigorous cell proliferation renders the core of the solid tumor hypoxic, the mitochondrial electron transport chain mediates ROS signaling for bringing about cellular adaptation to hypoxia. Highly aggressive cells are selected in this process, which are capable of progressing through the enhanced oxidative stress encountered during different stages of metastasis for distant colonization. Mitochondrial oxidative metabolism is suppressed to lower ROS generation, and the overall cellular metabolism is reprogrammed to maintain the optimum NADPH level in the mitochondria required for redox homeostasis. After reaching the distant organ, the intrinsic metabolic limitations of that organ dictate the success of colonization and flexibility of the mitochondrial metabolism of cancer cells plays a pivotal role in their adaptation to the new environment.
format	article
author	Feroza K. Choudhury
author_facet	Feroza K. Choudhury
author_sort	Feroza K. Choudhury
title	Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression
title_short	Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression
title_full	Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression
title_fullStr	Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression
title_full_unstemmed	Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression
title_sort	mitochondrial redox metabolism: the epicenter of metabolism during cancer progression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/adcb86488fbf411dbf004e7490036060
work_keys_str_mv	AT ferozakchoudhury mitochondrialredoxmetabolismtheepicenterofmetabolismduringcancerprogression
_version_	1718413159317897216

Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression

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