Biocompatible medical implant materials with binding sites for a biodegradable drug-delivery system

Haifa Al-Dubai1, Gisela Pittner1, Fritz Pittner1, Franz Gabor21Max F Perutz Laboratories, Department of Biochemistry, University of Vienna, Vienna, Austria; 2Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna, AustriaAbstract: Feasibi...

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Autores principales:	Al-Dubai H, Pittner G, Pittner F, Gabor F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medical technology R855-855.5 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/adcd1ba9e5e54a379fcfca252c616b8a
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spelling	oai:doaj.org-article:adcd1ba9e5e54a379fcfca252c616b8a2021-12-02T08:06:19ZBiocompatible medical implant materials with binding sites for a biodegradable drug-delivery system1177-8903https://doaj.org/article/adcd1ba9e5e54a379fcfca252c616b8a2011-10-01T00:00:00Zhttp://www.dovepress.com/biocompatible-medical-implant-materials-with-binding-sites-for-a-biode-a8396https://doaj.org/toc/1177-8903Haifa Al-Dubai1, Gisela Pittner1, Fritz Pittner1, Franz Gabor21Max F Perutz Laboratories, Department of Biochemistry, University of Vienna, Vienna, Austria; 2Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna, AustriaAbstract: Feasibility studies have been carried out for development of a biocompatible coating of medical implant materials allowing the binding of biodegradable drug-delivery systems in a way that their reloading might be possible. These novel coatings, able to bind biodegradable nanoparticles, may serve in the long run as drug carriers to mediate local pharmacological activity. After biodegradation of the nanoparticles, the binding sites could be reloaded with fresh drug-delivering particles. As a suitable receptor system for the nanoparticles, antibodies are anchored. The design of the receptor is of great importance as any bio- or chemorecognitive interaction with other components circulating in the blood has to be avoided. Furthermore, the binding between receptor and the particles has to be strong enough to keep them tightly bound during their lifetime, but on the other hand allow reloading after final degradation of the particles. The nanoparticles suggested as a drug-delivery system for medical implants can be loaded with different pharmaceuticals such as antibiotics, growth factors, or immunosuppressives. This concept may enable the changing of medication, even after implantation of the medical device, if afforded by patients&rsquo; needs.Keywords: antibody immobilization, biocompatible coating, chitosan nanoparticles, drug targeting, medical deviceAl-Dubai HPittner GPittner FGabor FDove Medical PressarticleMedical technologyR855-855.5Chemical technologyTP1-1185ENNanotechnology, Science and Applications, Vol 2011, Iss default, Pp 87-94 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5 Chemical technology TP1-1185
spellingShingle	Medical technology R855-855.5 Chemical technology TP1-1185 Al-Dubai H Pittner G Pittner F Gabor F Biocompatible medical implant materials with binding sites for a biodegradable drug-delivery system
description	Haifa Al-Dubai1, Gisela Pittner1, Fritz Pittner1, Franz Gabor21Max F Perutz Laboratories, Department of Biochemistry, University of Vienna, Vienna, Austria; 2Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna, AustriaAbstract: Feasibility studies have been carried out for development of a biocompatible coating of medical implant materials allowing the binding of biodegradable drug-delivery systems in a way that their reloading might be possible. These novel coatings, able to bind biodegradable nanoparticles, may serve in the long run as drug carriers to mediate local pharmacological activity. After biodegradation of the nanoparticles, the binding sites could be reloaded with fresh drug-delivering particles. As a suitable receptor system for the nanoparticles, antibodies are anchored. The design of the receptor is of great importance as any bio- or chemorecognitive interaction with other components circulating in the blood has to be avoided. Furthermore, the binding between receptor and the particles has to be strong enough to keep them tightly bound during their lifetime, but on the other hand allow reloading after final degradation of the particles. The nanoparticles suggested as a drug-delivery system for medical implants can be loaded with different pharmaceuticals such as antibiotics, growth factors, or immunosuppressives. This concept may enable the changing of medication, even after implantation of the medical device, if afforded by patients&rsquo; needs.Keywords: antibody immobilization, biocompatible coating, chitosan nanoparticles, drug targeting, medical device
format	article
author	Al-Dubai H Pittner G Pittner F Gabor F
author_facet	Al-Dubai H Pittner G Pittner F Gabor F
author_sort	Al-Dubai H
title	Biocompatible medical implant materials with binding sites for a biodegradable drug-delivery system
title_short	Biocompatible medical implant materials with binding sites for a biodegradable drug-delivery system
title_full	Biocompatible medical implant materials with binding sites for a biodegradable drug-delivery system
title_fullStr	Biocompatible medical implant materials with binding sites for a biodegradable drug-delivery system
title_full_unstemmed	Biocompatible medical implant materials with binding sites for a biodegradable drug-delivery system
title_sort	biocompatible medical implant materials with binding sites for a biodegradable drug-delivery system
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/adcd1ba9e5e54a379fcfca252c616b8a
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Biocompatible medical implant materials with binding sites for a biodegradable drug-delivery system

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