Cubosome nanoparticles potentiate immune properties of immunostimulants

Zhenguang Liu, Li Luo, Sisi Zheng, Yale Niu, Ruonan Bo, Yee Huang, Jie Xing, Zhihua Li, Deyun Wang Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China Abstract: Cubosomes have been expl...

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Autores principales:	Liu Z, Luo L, Zheng S, Niu Y, Bo R, Huang Y, Xing J, Li Z, Wang D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Cubosomes Polysaccharide Cryo-FESEM Lymph nodes Dendritic cells Memory T helper cell Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/adce3b721045460aa927bc1fa673fa63
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spelling	oai:doaj.org-article:adce3b721045460aa927bc1fa673fa632021-12-02T01:32:10ZCubosome nanoparticles potentiate immune properties of immunostimulants1178-2013https://doaj.org/article/adce3b721045460aa927bc1fa673fa632016-07-01T00:00:00Zhttps://www.dovepress.com/cubosome-nanoparticles-potentiate-immune-properties-of-immunostimulant-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zhenguang Liu, Li Luo, Sisi Zheng, Yale Niu, Ruonan Bo, Yee Huang, Jie Xing, Zhihua Li, Deyun Wang Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China Abstract: Cubosomes have been explored as drug and antigen carriers in the past few years. A few reports have described that cubosomes can enhance the ability of immunostimulants to generate strong immune responses. Polysaccharide (PS), an immunostimulant, has been reported to be a promising adjuvant for vaccines. Herein, we incorporated PS into cubosomes to generate PS–cubosome (Cub-PS) nanoparticles, and Cub-PS was characterized by small-angle X-ray scattering scattering and cryo-field emission scanning electron microscopy. The immunological activity of Cub-PS was compared with that of Cub and PS. The results demonstrated that Cub-PS elicited more potent immune responses than Cub or PS alone. The enhanced immune responses might be attributed to the promotion of antigen transport into draining lymph nodes and efficient dendritic cell activation and memory T-helper cell differentiation in draining lymph nodes. Overall, these findings indicate that cubosomes have the potential to enhance the ability of immunostimulants to generate an immune response. Keywords: cubosomes, polysaccharides, cryo-FESEM, lymph nodes, dendritic cells, memory T-helper cellsLiu ZLuo LZheng SNiu YBo RHuang YXing JLi ZWang DDove Medical PressarticleCubosomesPolysaccharideCryo-FESEMLymph nodesDendritic cellsMemory T helper cellMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 3571-3583 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cubosomes Polysaccharide Cryo-FESEM Lymph nodes Dendritic cells Memory T helper cell Medicine (General) R5-920
spellingShingle	Cubosomes Polysaccharide Cryo-FESEM Lymph nodes Dendritic cells Memory T helper cell Medicine (General) R5-920 Liu Z Luo L Zheng S Niu Y Bo R Huang Y Xing J Li Z Wang D Cubosome nanoparticles potentiate immune properties of immunostimulants
description	Zhenguang Liu, Li Luo, Sisi Zheng, Yale Niu, Ruonan Bo, Yee Huang, Jie Xing, Zhihua Li, Deyun Wang Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China Abstract: Cubosomes have been explored as drug and antigen carriers in the past few years. A few reports have described that cubosomes can enhance the ability of immunostimulants to generate strong immune responses. Polysaccharide (PS), an immunostimulant, has been reported to be a promising adjuvant for vaccines. Herein, we incorporated PS into cubosomes to generate PS–cubosome (Cub-PS) nanoparticles, and Cub-PS was characterized by small-angle X-ray scattering scattering and cryo-field emission scanning electron microscopy. The immunological activity of Cub-PS was compared with that of Cub and PS. The results demonstrated that Cub-PS elicited more potent immune responses than Cub or PS alone. The enhanced immune responses might be attributed to the promotion of antigen transport into draining lymph nodes and efficient dendritic cell activation and memory T-helper cell differentiation in draining lymph nodes. Overall, these findings indicate that cubosomes have the potential to enhance the ability of immunostimulants to generate an immune response. Keywords: cubosomes, polysaccharides, cryo-FESEM, lymph nodes, dendritic cells, memory T-helper cells
format	article
author	Liu Z Luo L Zheng S Niu Y Bo R Huang Y Xing J Li Z Wang D
author_facet	Liu Z Luo L Zheng S Niu Y Bo R Huang Y Xing J Li Z Wang D
author_sort	Liu Z
title	Cubosome nanoparticles potentiate immune properties of immunostimulants
title_short	Cubosome nanoparticles potentiate immune properties of immunostimulants
title_full	Cubosome nanoparticles potentiate immune properties of immunostimulants
title_fullStr	Cubosome nanoparticles potentiate immune properties of immunostimulants
title_full_unstemmed	Cubosome nanoparticles potentiate immune properties of immunostimulants
title_sort	cubosome nanoparticles potentiate immune properties of immunostimulants
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/adce3b721045460aa927bc1fa673fa63
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Cubosome nanoparticles potentiate immune properties of immunostimulants

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