Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics

In order to examine how central amygdala (CE) local circuitry interacts with brain-wide affective states, Wank et al performed gene expression analysis and optogenetic fMRI in mice, using basic nociception as a proxy. They found evidence for diverging roles of two major CE neuronal populations in mo...

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Autores principales: Isabel Wank, Pinelopi Pliota, Sylvia Badurek, Klaus Kraitsy, Joanna Kaczanowska, Johannes Griessner, Silke Kreitz, Andreas Hess, Wulf Haubensak
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/add3e663f08a42978501e1db0419ed1b
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Sumario:In order to examine how central amygdala (CE) local circuitry interacts with brain-wide affective states, Wank et al performed gene expression analysis and optogenetic fMRI in mice, using basic nociception as a proxy. They found evidence for diverging roles of two major CE neuronal populations in modulating global brain states, which impacts on aversive processing and nocifensive behaviour.