GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives

Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thick...

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Autores principales:	Gerardo Cazzato, Anna Colagrande, Antonietta Cimmino, Caterina Abbatepaolo, Emilio Bellitti, Paolo Romita, Lucia Lospalluti, Caterina Foti, Francesca Arezzo, Vera Loizzi, Teresa Lettini, Sara Sablone, Leonardo Resta, Gennaro Cormio, Giuseppe Ingravallo, Roberta Rossi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	GLUT1 GLUT3 malignant melanoma immunohistochemistry perspectives Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/add43add2b6a4482a075cc3b0644852e
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spelling	oai:doaj.org-article:add43add2b6a4482a075cc3b0644852e2021-11-25T17:11:23ZGLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives10.3390/cells101130902073-4409https://doaj.org/article/add43add2b6a4482a075cc3b0644852e2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3090https://doaj.org/toc/2073-4409Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thickness greater than 1 mm is still quite poor today. The study of how melanoma cells manage to survive and proliferate by consuming glucose has been partially addressed in the literature, but some rather interesting results are starting to be present. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a search of PubMed and Web of Sciences (WoS) databases was performed until 27 September 2021 using the terms: glucose transporter 1 and 3 and GLUT1/3 in combination with each of the following: melanoma, neoplasm and immunohistochemistry. Results: In total, 46 records were initially identified in the literature search, of which six were duplicates. After screening for eligibility and inclusion criteria, 16 publications were ultimately included. Conclusions: the results discussed regarding the role and expression of GLUT are still far from definitive, but further steps toward understanding and stopping this mechanism have, at least in part, been taken. New studies and new discoveries should lead to further clarification of some aspects since the various mechanisms of glucose uptake by neoplastic cells are not limited to the transporters of the GLUT family alone.Gerardo CazzatoAnna ColagrandeAntonietta CimminoCaterina AbbatepaoloEmilio BellittiPaolo RomitaLucia LospallutiCaterina FotiFrancesca ArezzoVera LoizziTeresa LettiniSara SabloneLeonardo RestaGennaro CormioGiuseppe IngravalloRoberta RossiMDPI AGarticleGLUT1GLUT3malignant melanomaimmunohistochemistryperspectivesBiology (General)QH301-705.5ENCells, Vol 10, Iss 3090, p 3090 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	GLUT1 GLUT3 malignant melanoma immunohistochemistry perspectives Biology (General) QH301-705.5
spellingShingle	GLUT1 GLUT3 malignant melanoma immunohistochemistry perspectives Biology (General) QH301-705.5 Gerardo Cazzato Anna Colagrande Antonietta Cimmino Caterina Abbatepaolo Emilio Bellitti Paolo Romita Lucia Lospalluti Caterina Foti Francesca Arezzo Vera Loizzi Teresa Lettini Sara Sablone Leonardo Resta Gennaro Cormio Giuseppe Ingravallo Roberta Rossi GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
description	Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thickness greater than 1 mm is still quite poor today. The study of how melanoma cells manage to survive and proliferate by consuming glucose has been partially addressed in the literature, but some rather interesting results are starting to be present. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a search of PubMed and Web of Sciences (WoS) databases was performed until 27 September 2021 using the terms: glucose transporter 1 and 3 and GLUT1/3 in combination with each of the following: melanoma, neoplasm and immunohistochemistry. Results: In total, 46 records were initially identified in the literature search, of which six were duplicates. After screening for eligibility and inclusion criteria, 16 publications were ultimately included. Conclusions: the results discussed regarding the role and expression of GLUT are still far from definitive, but further steps toward understanding and stopping this mechanism have, at least in part, been taken. New studies and new discoveries should lead to further clarification of some aspects since the various mechanisms of glucose uptake by neoplastic cells are not limited to the transporters of the GLUT family alone.
format	article
author	Gerardo Cazzato Anna Colagrande Antonietta Cimmino Caterina Abbatepaolo Emilio Bellitti Paolo Romita Lucia Lospalluti Caterina Foti Francesca Arezzo Vera Loizzi Teresa Lettini Sara Sablone Leonardo Resta Gennaro Cormio Giuseppe Ingravallo Roberta Rossi
author_facet	Gerardo Cazzato Anna Colagrande Antonietta Cimmino Caterina Abbatepaolo Emilio Bellitti Paolo Romita Lucia Lospalluti Caterina Foti Francesca Arezzo Vera Loizzi Teresa Lettini Sara Sablone Leonardo Resta Gennaro Cormio Giuseppe Ingravallo Roberta Rossi
author_sort	Gerardo Cazzato
title	GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
title_short	GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
title_full	GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
title_fullStr	GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
title_full_unstemmed	GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
title_sort	glut1, glut3 expression and 18fdg-pet/ct in human malignant melanoma: what relationship exists? new insights and perspectives
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/add43add2b6a4482a075cc3b0644852e
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GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives

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