Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study

Abstract Gastroesophageal reflux disease (GERD) and Barrett’s Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked to obstructive airways disease (OAD). We a...

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Autores principales:	Syed H. Haider, Sophia Kwon, Rachel Lam, Audrey K. Lee, Erin J. Caraher, George Crowley, Liqun Zhang, Theresa M. Schwartz, Rachel Zeig-Owens, Mengling Liu, David J. Prezant, Anna Nolan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/add5c302a0b84773bf330592a32303b5
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spelling	oai:doaj.org-article:add5c302a0b84773bf330592a32303b52021-12-02T15:07:59ZPredictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study10.1038/s41598-018-21334-92045-2322https://doaj.org/article/add5c302a0b84773bf330592a32303b52018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21334-9https://doaj.org/toc/2045-2322Abstract Gastroesophageal reflux disease (GERD) and Barrett’s Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked to obstructive airways disease (OAD). We aim to identify serum biomarkers of GERD/BE, and assess the respiratory and clinical phenotype of a longitudinal cohort of never-smoking, male, WTC-exposed rescue workers presenting with pulmonary symptoms. Biomarkers collected soon after WTC-exposure were evaluated in optimized predictive models of GERD/BE. In the WTC-exposed cohort, the prevalence of BE is at least 6 times higher than in the general population. GERD/BE cases had similar lung function, D LCO , bronchodilator response and long-acting β-agonist use compared to controls. In confounder-adjusted regression models, TNF-α ≥ 6 pg/mL predicted both GERD and BE. GERD was also predicted by C-peptide ≥ 360 pg/mL, while BE was predicted by fractalkine ≥ 250 pg/mL and IP-10 ≥ 290 pg/mL. Finally, participants with GERD had significantly increased use of short-acting β-agonist compared to controls. Overall, biomarkers sampled prior to GERD/BE presentation showed strong predictive abilities of disease development. This study frames future investigations to further our understanding of aerodigestive pathology due to particulate matter exposure.Syed H. HaiderSophia KwonRachel LamAudrey K. LeeErin J. CaraherGeorge CrowleyLiqun ZhangTheresa M. SchwartzRachel Zeig-OwensMengling LiuDavid J. PrezantAnna NolanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Syed H. Haider Sophia Kwon Rachel Lam Audrey K. Lee Erin J. Caraher George Crowley Liqun Zhang Theresa M. Schwartz Rachel Zeig-Owens Mengling Liu David J. Prezant Anna Nolan Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study
description	Abstract Gastroesophageal reflux disease (GERD) and Barrett’s Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked to obstructive airways disease (OAD). We aim to identify serum biomarkers of GERD/BE, and assess the respiratory and clinical phenotype of a longitudinal cohort of never-smoking, male, WTC-exposed rescue workers presenting with pulmonary symptoms. Biomarkers collected soon after WTC-exposure were evaluated in optimized predictive models of GERD/BE. In the WTC-exposed cohort, the prevalence of BE is at least 6 times higher than in the general population. GERD/BE cases had similar lung function, D LCO , bronchodilator response and long-acting β-agonist use compared to controls. In confounder-adjusted regression models, TNF-α ≥ 6 pg/mL predicted both GERD and BE. GERD was also predicted by C-peptide ≥ 360 pg/mL, while BE was predicted by fractalkine ≥ 250 pg/mL and IP-10 ≥ 290 pg/mL. Finally, participants with GERD had significantly increased use of short-acting β-agonist compared to controls. Overall, biomarkers sampled prior to GERD/BE presentation showed strong predictive abilities of disease development. This study frames future investigations to further our understanding of aerodigestive pathology due to particulate matter exposure.
format	article
author	Syed H. Haider Sophia Kwon Rachel Lam Audrey K. Lee Erin J. Caraher George Crowley Liqun Zhang Theresa M. Schwartz Rachel Zeig-Owens Mengling Liu David J. Prezant Anna Nolan
author_facet	Syed H. Haider Sophia Kwon Rachel Lam Audrey K. Lee Erin J. Caraher George Crowley Liqun Zhang Theresa M. Schwartz Rachel Zeig-Owens Mengling Liu David J. Prezant Anna Nolan
author_sort	Syed H. Haider
title	Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study
title_short	Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study
title_full	Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study
title_fullStr	Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study
title_full_unstemmed	Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study
title_sort	predictive biomarkers of gastroesophageal reflux disease and barrett’s esophagus in world trade center exposed firefighters: a 15 year longitudinal study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/add5c302a0b84773bf330592a32303b5
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Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study

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