Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity

Abstract Doxorubicin is a chemotherapeutic agent known to cause cardiotoxicity that is thought to be associated with oxidative stress. The aim of the current study is to investigate the role of grape polyphenols’ antioxidant property as cardioprotective against doxorubicin-induced cardiotoxicity. Ad...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shynggys Sergazy, Zarina Shulgau, Galina Fedotovskikh, Laura Chulenbayeva, Ayaulym Nurgozhina, Madiyar Nurgaziyev, Elena Krivyh, Yevgeny Kamyshanskiy, Almagul Kushugulova, Alexander Gulyayev, Mohamad Aljofan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/addb75b23a534e15b589a362043d8cef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:addb75b23a534e15b589a362043d8cef
record_format	dspace
spelling	oai:doaj.org-article:addb75b23a534e15b589a362043d8cef2021-12-02T19:12:33ZCardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity10.1038/s41598-020-71827-92045-2322https://doaj.org/article/addb75b23a534e15b589a362043d8cef2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-71827-9https://doaj.org/toc/2045-2322Abstract Doxorubicin is a chemotherapeutic agent known to cause cardiotoxicity that is thought to be associated with oxidative stress. The aim of the current study is to investigate the role of grape polyphenols’ antioxidant property as cardioprotective against doxorubicin-induced cardiotoxicity. Adult Wistar rats weighing 200 ± 20 g were divided into 3 different groups: a doxorubicin group that received a single intraperitoneal administration of doxorubicin (8.0 mg/kg body weight), an experimental group that received doxorubicin and grape polyphenol concentrate (25 mg/kg) via intragastric route, and the third group was a negative control group that received water only. On day 8, blood samples and tissues were harvested for analyses. The results indicated that grape polyphenol concentrate was able to reduce the signs of cardiotoxicity of doxorubicin through the reduction of aspartate aminotransferase activation, increasing the plasma antioxidant levels and decreasing the level of free radicals. The results also showed that grape polyphenol concentrate was able to reverse doxorubicin-induced microscopic myocardial damage. The myocardial protective effect of grape polyphenol might likely be due to the increase in the level and activity of the antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase. In conclusion, grape polyphenol concentrate displayed cardioprotective effect and was able to reverse doxorubicin-induced-cardiomyopathy in experimental rats.Shynggys SergazyZarina ShulgauGalina FedotovskikhLaura ChulenbayevaAyaulym NurgozhinaMadiyar NurgaziyevElena KrivyhYevgeny KamyshanskiyAlmagul KushugulovaAlexander GulyayevMohamad AljofanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shynggys Sergazy Zarina Shulgau Galina Fedotovskikh Laura Chulenbayeva Ayaulym Nurgozhina Madiyar Nurgaziyev Elena Krivyh Yevgeny Kamyshanskiy Almagul Kushugulova Alexander Gulyayev Mohamad Aljofan Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity
description	Abstract Doxorubicin is a chemotherapeutic agent known to cause cardiotoxicity that is thought to be associated with oxidative stress. The aim of the current study is to investigate the role of grape polyphenols’ antioxidant property as cardioprotective against doxorubicin-induced cardiotoxicity. Adult Wistar rats weighing 200 ± 20 g were divided into 3 different groups: a doxorubicin group that received a single intraperitoneal administration of doxorubicin (8.0 mg/kg body weight), an experimental group that received doxorubicin and grape polyphenol concentrate (25 mg/kg) via intragastric route, and the third group was a negative control group that received water only. On day 8, blood samples and tissues were harvested for analyses. The results indicated that grape polyphenol concentrate was able to reduce the signs of cardiotoxicity of doxorubicin through the reduction of aspartate aminotransferase activation, increasing the plasma antioxidant levels and decreasing the level of free radicals. The results also showed that grape polyphenol concentrate was able to reverse doxorubicin-induced microscopic myocardial damage. The myocardial protective effect of grape polyphenol might likely be due to the increase in the level and activity of the antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase. In conclusion, grape polyphenol concentrate displayed cardioprotective effect and was able to reverse doxorubicin-induced-cardiomyopathy in experimental rats.
format	article
author	Shynggys Sergazy Zarina Shulgau Galina Fedotovskikh Laura Chulenbayeva Ayaulym Nurgozhina Madiyar Nurgaziyev Elena Krivyh Yevgeny Kamyshanskiy Almagul Kushugulova Alexander Gulyayev Mohamad Aljofan
author_facet	Shynggys Sergazy Zarina Shulgau Galina Fedotovskikh Laura Chulenbayeva Ayaulym Nurgozhina Madiyar Nurgaziyev Elena Krivyh Yevgeny Kamyshanskiy Almagul Kushugulova Alexander Gulyayev Mohamad Aljofan
author_sort	Shynggys Sergazy
title	Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity
title_short	Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity
title_full	Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity
title_fullStr	Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity
title_full_unstemmed	Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity
title_sort	cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/addb75b23a534e15b589a362043d8cef
work_keys_str_mv	AT shynggyssergazy cardioprotectiveeffectofgrapepolyphenolextractagainstdoxorubicininducedcardiotoxicity AT zarinashulgau cardioprotectiveeffectofgrapepolyphenolextractagainstdoxorubicininducedcardiotoxicity AT galinafedotovskikh cardioprotectiveeffectofgrapepolyphenolextractagainstdoxorubicininducedcardiotoxicity AT laurachulenbayeva cardioprotectiveeffectofgrapepolyphenolextractagainstdoxorubicininducedcardiotoxicity AT ayaulymnurgozhina cardioprotectiveeffectofgrapepolyphenolextractagainstdoxorubicininducedcardiotoxicity AT madiyarnurgaziyev cardioprotectiveeffectofgrapepolyphenolextractagainstdoxorubicininducedcardiotoxicity AT elenakrivyh cardioprotectiveeffectofgrapepolyphenolextractagainstdoxorubicininducedcardiotoxicity AT yevgenykamyshanskiy cardioprotectiveeffectofgrapepolyphenolextractagainstdoxorubicininducedcardiotoxicity AT almagulkushugulova cardioprotectiveeffectofgrapepolyphenolextractagainstdoxorubicininducedcardiotoxicity AT alexandergulyayev cardioprotectiveeffectofgrapepolyphenolextractagainstdoxorubicininducedcardiotoxicity AT mohamadaljofan cardioprotectiveeffectofgrapepolyphenolextractagainstdoxorubicininducedcardiotoxicity
_version_	1718377025665761280

Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity

Ejemplares similares