Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review

Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is the most common periodic fever condition in children, with most cases appearing by the age of 5. Although PFAPA is generally a self-limited condition, it can have a major impact on a child's quality of life, as w...

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Autores principales:	Alicia Wang, Kalpana Manthiram, Fatma Dedeoglu, Greg R. Licameli
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	PFAPA Periodic fever Recurrent fever Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/addecba13b1f47bfb2620de92673a057
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spelling	oai:doaj.org-article:addecba13b1f47bfb2620de92673a0572021-12-02T14:51:52ZPeriodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review2095-881110.1016/j.wjorl.2021.05.004https://doaj.org/article/addecba13b1f47bfb2620de92673a0572021-07-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881121000482https://doaj.org/toc/2095-8811Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is the most common periodic fever condition in children, with most cases appearing by the age of 5. Although PFAPA is generally a self-limited condition, it can have a major impact on a child's quality of life, as well as that of their family. Recent research has continued to shed light on the genetic and immunologic factors that play a role in the pathogenesis of PFAPA. There also exists significant heterogeneity in treatment strategies, and progress has been made to develop evidence-based management strategies and establish a standard of care. This review will outline current knowledge regarding the pathogenesis of PFAPA, as well as treatment strategies and our clinical experience.Alicia WangKalpana ManthiramFatma DedeogluGreg R. LicameliKeAi Communications Co., Ltd.articlePFAPAPeriodic feverRecurrent feverOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 7, Iss 3, Pp 166-173 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PFAPA Periodic fever Recurrent fever Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	PFAPA Periodic fever Recurrent fever Otorhinolaryngology RF1-547 Surgery RD1-811 Alicia Wang Kalpana Manthiram Fatma Dedeoglu Greg R. Licameli Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review
description	Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is the most common periodic fever condition in children, with most cases appearing by the age of 5. Although PFAPA is generally a self-limited condition, it can have a major impact on a child's quality of life, as well as that of their family. Recent research has continued to shed light on the genetic and immunologic factors that play a role in the pathogenesis of PFAPA. There also exists significant heterogeneity in treatment strategies, and progress has been made to develop evidence-based management strategies and establish a standard of care. This review will outline current knowledge regarding the pathogenesis of PFAPA, as well as treatment strategies and our clinical experience.
format	article
author	Alicia Wang Kalpana Manthiram Fatma Dedeoglu Greg R. Licameli
author_facet	Alicia Wang Kalpana Manthiram Fatma Dedeoglu Greg R. Licameli
author_sort	Alicia Wang
title	Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review
title_short	Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review
title_full	Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review
title_fullStr	Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review
title_full_unstemmed	Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review
title_sort	periodic fever, aphthous stomatitis, pharyngitis, and adenitis (pfapa) syndrome: a review
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/addecba13b1f47bfb2620de92673a057
work_keys_str_mv	AT aliciawang periodicfeveraphthousstomatitispharyngitisandadenitispfapasyndromeareview AT kalpanamanthiram periodicfeveraphthousstomatitispharyngitisandadenitispfapasyndromeareview AT fatmadedeoglu periodicfeveraphthousstomatitispharyngitisandadenitispfapasyndromeareview AT gregrlicameli periodicfeveraphthousstomatitispharyngitisandadenitispfapasyndromeareview
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Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review

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