Structure of human RNA polymerase III

The eukaryotic RNA Polymerase III transcribes tRNAs, some ribosomal and spliceosomal RNAs. Here, the authors resolve a cryo-EM structure of human RNA Polymerase III in its apo form and complemented it with crystal structures and SAXS analysis of RPC5, revealing insights into the molecular mechanisms...

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Autores principales:	Ewan Phillip Ramsay, Guillermo Abascal-Palacios, Julia L. Daiß, Helen King, Jerome Gouge, Michael Pilsl, Fabienne Beuron, Edward Morris, Philip Gunkel, Christoph Engel, Alessandro Vannini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/addf731bc84249d4a4c0c47a0f5420f5
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spelling	oai:doaj.org-article:addf731bc84249d4a4c0c47a0f5420f52021-12-02T10:48:29ZStructure of human RNA polymerase III10.1038/s41467-020-20262-52041-1723https://doaj.org/article/addf731bc84249d4a4c0c47a0f5420f52020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20262-5https://doaj.org/toc/2041-1723The eukaryotic RNA Polymerase III transcribes tRNAs, some ribosomal and spliceosomal RNAs. Here, the authors resolve a cryo-EM structure of human RNA Polymerase III in its apo form and complemented it with crystal structures and SAXS analysis of RPC5, revealing insights into the molecular mechanisms of Pol III transcription.Ewan Phillip RamsayGuillermo Abascal-PalaciosJulia L. DaißHelen KingJerome GougeMichael PilslFabienne BeuronEdward MorrisPhilip GunkelChristoph EngelAlessandro VanniniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ewan Phillip Ramsay Guillermo Abascal-Palacios Julia L. Daiß Helen King Jerome Gouge Michael Pilsl Fabienne Beuron Edward Morris Philip Gunkel Christoph Engel Alessandro Vannini Structure of human RNA polymerase III
description	The eukaryotic RNA Polymerase III transcribes tRNAs, some ribosomal and spliceosomal RNAs. Here, the authors resolve a cryo-EM structure of human RNA Polymerase III in its apo form and complemented it with crystal structures and SAXS analysis of RPC5, revealing insights into the molecular mechanisms of Pol III transcription.
format	article
author	Ewan Phillip Ramsay Guillermo Abascal-Palacios Julia L. Daiß Helen King Jerome Gouge Michael Pilsl Fabienne Beuron Edward Morris Philip Gunkel Christoph Engel Alessandro Vannini
author_facet	Ewan Phillip Ramsay Guillermo Abascal-Palacios Julia L. Daiß Helen King Jerome Gouge Michael Pilsl Fabienne Beuron Edward Morris Philip Gunkel Christoph Engel Alessandro Vannini
author_sort	Ewan Phillip Ramsay
title	Structure of human RNA polymerase III
title_short	Structure of human RNA polymerase III
title_full	Structure of human RNA polymerase III
title_fullStr	Structure of human RNA polymerase III
title_full_unstemmed	Structure of human RNA polymerase III
title_sort	structure of human rna polymerase iii
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/addf731bc84249d4a4c0c47a0f5420f5
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Structure of human RNA polymerase III

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