Oral drug therapy in elderly with dysphagia: between a rock and a hard place!

Serena Logrippo,1,2 Giovanna Ricci,3 Matteo Sestili,4 Marco Cespi,2 Letizia Ferrara,4 Giovanni F Palmieri,2 Roberta Ganzetti,4 Giulia Bonacucina,2 Paolo Blasi2 1School of Advanced Studies, 2School of Pharmacy, 3School of Law, University of Camerino, Camerino, 4Italian National Research Centers on A...

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Autores principales:	Logrippo S, Ricci G, Sestili M, Cespi M, Ferrara L, Palmieri GF, Ganzetti R, Bonacucina G, Blasi P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Geriatric medicine dysphagia compounding modified-release formulations gastro-intestinal tract toxicity. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ade2d3aa119740c18af7fe28cb9be042
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spelling	oai:doaj.org-article:ade2d3aa119740c18af7fe28cb9be0422021-12-02T01:38:59ZOral drug therapy in elderly with dysphagia: between a rock and a hard place!1178-1998https://doaj.org/article/ade2d3aa119740c18af7fe28cb9be0422017-01-01T00:00:00Zhttps://www.dovepress.com/oral-drug-therapy-in-elderly-with-dysphagia-between-a-rock-and-a-hard--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Serena Logrippo,1,2 Giovanna Ricci,3 Matteo Sestili,4 Marco Cespi,2 Letizia Ferrara,4 Giovanni F Palmieri,2 Roberta Ganzetti,4 Giulia Bonacucina,2 Paolo Blasi2 1School of Advanced Studies, 2School of Pharmacy, 3School of Law, University of Camerino, Camerino, 4Italian National Research Centers on Ageing (INRCA), Ancona, Italy Abstract: Demographic indicators forecast that by 2050, the elderly will account for about one-third of the global population. Geriatric patients require a large number of medicines, and in most cases, these products are administered as solid oral solid dosage forms, as they are by far the most common formulations on the market. However, this population tends to suffer difficulties with swallowing. Caregivers in hospital geriatric units routinely compound in solid oral dosage forms for dysphagic patients by crushing the tablets or opening the capsules to facilitate administration. The manipulation of a tablet or a capsule, if not clearly indicated in the product labeling, is an off-label use of the medicine, and must be supported by documented scientific evidence and requires the patient’s informed consent. Compounding of marketed products has been recognized as being responsible for an increased number of adverse events and medical errors. Since extemporaneous compounding is the rule and not the exception in geriatrics departments, the seriousness and scope of issues caused by this daily practice are probably underestimated. In this article, the potential problems associated with the manipulation of authorized solid oral dosage forms are discussed. Keywords: geriatric medicine, dysphagia, compounding, modified-release formulations, gastrointestinal tract toxicityLogrippo SRicci GSestili MCespi MFerrara LPalmieri GFGanzetti RBonacucina GBlasi PDove Medical PressarticleGeriatric medicinedysphagiacompoundingmodified-release formulationsgastro-intestinal tract toxicity.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 241-251 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatric medicine dysphagia compounding modified-release formulations gastro-intestinal tract toxicity. Geriatrics RC952-954.6
spellingShingle	Geriatric medicine dysphagia compounding modified-release formulations gastro-intestinal tract toxicity. Geriatrics RC952-954.6 Logrippo S Ricci G Sestili M Cespi M Ferrara L Palmieri GF Ganzetti R Bonacucina G Blasi P Oral drug therapy in elderly with dysphagia: between a rock and a hard place!
description	Serena Logrippo,1,2 Giovanna Ricci,3 Matteo Sestili,4 Marco Cespi,2 Letizia Ferrara,4 Giovanni F Palmieri,2 Roberta Ganzetti,4 Giulia Bonacucina,2 Paolo Blasi2 1School of Advanced Studies, 2School of Pharmacy, 3School of Law, University of Camerino, Camerino, 4Italian National Research Centers on Ageing (INRCA), Ancona, Italy Abstract: Demographic indicators forecast that by 2050, the elderly will account for about one-third of the global population. Geriatric patients require a large number of medicines, and in most cases, these products are administered as solid oral solid dosage forms, as they are by far the most common formulations on the market. However, this population tends to suffer difficulties with swallowing. Caregivers in hospital geriatric units routinely compound in solid oral dosage forms for dysphagic patients by crushing the tablets or opening the capsules to facilitate administration. The manipulation of a tablet or a capsule, if not clearly indicated in the product labeling, is an off-label use of the medicine, and must be supported by documented scientific evidence and requires the patient’s informed consent. Compounding of marketed products has been recognized as being responsible for an increased number of adverse events and medical errors. Since extemporaneous compounding is the rule and not the exception in geriatrics departments, the seriousness and scope of issues caused by this daily practice are probably underestimated. In this article, the potential problems associated with the manipulation of authorized solid oral dosage forms are discussed. Keywords: geriatric medicine, dysphagia, compounding, modified-release formulations, gastrointestinal tract toxicity
format	article
author	Logrippo S Ricci G Sestili M Cespi M Ferrara L Palmieri GF Ganzetti R Bonacucina G Blasi P
author_facet	Logrippo S Ricci G Sestili M Cespi M Ferrara L Palmieri GF Ganzetti R Bonacucina G Blasi P
author_sort	Logrippo S
title	Oral drug therapy in elderly with dysphagia: between a rock and a hard place!
title_short	Oral drug therapy in elderly with dysphagia: between a rock and a hard place!
title_full	Oral drug therapy in elderly with dysphagia: between a rock and a hard place!
title_fullStr	Oral drug therapy in elderly with dysphagia: between a rock and a hard place!
title_full_unstemmed	Oral drug therapy in elderly with dysphagia: between a rock and a hard place!
title_sort	oral drug therapy in elderly with dysphagia: between a rock and a hard place!
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/ade2d3aa119740c18af7fe28cb9be042
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Oral drug therapy in elderly with dysphagia: between a rock and a hard place!

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