VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body

Abstract Only free drugs have been believed to be carried into tissues through active or passive transport. However, considering that lipoproteins function as carriers of serum lipids such as cholesterol and triglycerides, we hypothesized that lipoproteins can associate with certain drugs and mediat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hideaki Yamamoto, Tappei Takada, Yoshihide Yamanashi, Masatsune Ogura, Yusuke Masuo, Mariko Harada-Shiba, Hiroshi Suzuki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ade39f21094d45a2abb17fa1f743be7b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ade39f21094d45a2abb17fa1f743be7b
record_format	dspace
spelling	oai:doaj.org-article:ade39f21094d45a2abb17fa1f743be7b2021-12-02T11:53:13ZVLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body10.1038/s41598-017-00685-92045-2322https://doaj.org/article/ade39f21094d45a2abb17fa1f743be7b2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00685-9https://doaj.org/toc/2045-2322Abstract Only free drugs have been believed to be carried into tissues through active or passive transport. However, considering that lipoproteins function as carriers of serum lipids such as cholesterol and triglycerides, we hypothesized that lipoproteins can associate with certain drugs and mediate their transport into tissues in lipid-associated form. Here, in vitro and in vivo studies with low density lipoprotein receptor (LDLR)-overexpressing or -knockdown cells and wild-type or LDLR-mutant mice were used to show the association of various drugs with lipoproteins and the uptake of lipoprotein-associated drugs through a lipoprotein receptor-mediated process. In clinical studies, investigation of the effect of lipoprotein apheresis on serum drug concentrations in patients with familial hypercholesterolemia demonstrated that lipoprotein-mediated drug transport occurs in humans as well as in mice. These findings represent a new concept regarding the transport and metabolism of drugs in the body and suggest that the role of lipoprotein-mediated drug transport should be considered when developing effective and safe pharmacotherapies.Hideaki YamamotoTappei TakadaYoshihide YamanashiMasatsune OguraYusuke MasuoMariko Harada-ShibaHiroshi SuzukiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hideaki Yamamoto Tappei Takada Yoshihide Yamanashi Masatsune Ogura Yusuke Masuo Mariko Harada-Shiba Hiroshi Suzuki VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body
description	Abstract Only free drugs have been believed to be carried into tissues through active or passive transport. However, considering that lipoproteins function as carriers of serum lipids such as cholesterol and triglycerides, we hypothesized that lipoproteins can associate with certain drugs and mediate their transport into tissues in lipid-associated form. Here, in vitro and in vivo studies with low density lipoprotein receptor (LDLR)-overexpressing or -knockdown cells and wild-type or LDLR-mutant mice were used to show the association of various drugs with lipoproteins and the uptake of lipoprotein-associated drugs through a lipoprotein receptor-mediated process. In clinical studies, investigation of the effect of lipoprotein apheresis on serum drug concentrations in patients with familial hypercholesterolemia demonstrated that lipoprotein-mediated drug transport occurs in humans as well as in mice. These findings represent a new concept regarding the transport and metabolism of drugs in the body and suggest that the role of lipoprotein-mediated drug transport should be considered when developing effective and safe pharmacotherapies.
format	article
author	Hideaki Yamamoto Tappei Takada Yoshihide Yamanashi Masatsune Ogura Yusuke Masuo Mariko Harada-Shiba Hiroshi Suzuki
author_facet	Hideaki Yamamoto Tappei Takada Yoshihide Yamanashi Masatsune Ogura Yusuke Masuo Mariko Harada-Shiba Hiroshi Suzuki
author_sort	Hideaki Yamamoto
title	VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body
title_short	VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body
title_full	VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body
title_fullStr	VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body
title_full_unstemmed	VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body
title_sort	vldl/ldl acts as a drug carrier and regulates the transport and metabolism of drugs in the body
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ade39f21094d45a2abb17fa1f743be7b
work_keys_str_mv	AT hideakiyamamoto vldlldlactsasadrugcarrierandregulatesthetransportandmetabolismofdrugsinthebody AT tappeitakada vldlldlactsasadrugcarrierandregulatesthetransportandmetabolismofdrugsinthebody AT yoshihideyamanashi vldlldlactsasadrugcarrierandregulatesthetransportandmetabolismofdrugsinthebody AT masatsuneogura vldlldlactsasadrugcarrierandregulatesthetransportandmetabolismofdrugsinthebody AT yusukemasuo vldlldlactsasadrugcarrierandregulatesthetransportandmetabolismofdrugsinthebody AT marikoharadashiba vldlldlactsasadrugcarrierandregulatesthetransportandmetabolismofdrugsinthebody AT hiroshisuzuki vldlldlactsasadrugcarrierandregulatesthetransportandmetabolismofdrugsinthebody
_version_	1718394826704027648

VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body

Ejemplares similares