Altered intra- and interregional synchronization in relapsing–remitting multiple sclerosis: a resting-state fMRI study

Altered intra- and interregional synchronization in relapsing–remitting multiple sclerosis: a resting-state fMRI study

Lin Wu,1,2,* Yue Zhang,3,* Fuqing Zhou,1,2,* Lei Gao,2 Laichang He,1,2 Xianjun Zeng,1,2 Honghan Gong1,2 1Department of Radiology, The First Affiliated Hospital, Nanchang University, 2Jiangxi Province Medical Imaging Research Institute, 3Department of Radiology, The Affiliated Hospital of Jiangxi Un...

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Autores principales: Wu L, Zhang Y, Zhou F, Gao L, He L, Zeng X, Gong H
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
relapsing-remitting multiple sclerosis
functional MRI
resting-state
regional homogeneity
functional connectivity
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/ade6db5734d2476a9df641bff02c1527
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spelling oai:doaj.org-article:ade6db5734d2476a9df641bff02c15272021-12-02T07:20:58ZAltered intra- and interregional synchronization in relapsing–remitting multiple sclerosis: a resting-state fMRI study1178-2021https://doaj.org/article/ade6db5734d2476a9df641bff02c15272016-04-01T00:00:00Zhttps://www.dovepress.com/altered-intra--and-interregional-synchronization-in-relapsingndashremi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lin Wu,1,2,* Yue Zhang,3,* Fuqing Zhou,1,2,* Lei Gao,2 Laichang He,1,2 Xianjun Zeng,1,2 Honghan Gong1,2 1Department of Radiology, The First Affiliated Hospital, Nanchang University, 2Jiangxi Province Medical Imaging Research Institute, 3Department of Radiology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, People’s Republic of China *These authors contributed equally to this work Background and purpose: Neuroimaging studies of relapsing–remitting multiple sclerosis (RRMS) have found structural disconnection and large-scale neural network dysfunction. However, few studies have explored the local brain activity of RRMS patients in the resting state. Patients and methods: In this study, regional homogeneity (ReHo) and resting-state functional connectivity (FC) were used to investigate intra- and interregional synchronized activity in 22 patients with RRMS and 22 matched healthy controls (HCs). Results: Compared with HCs, patients with RRMS showed significantly decreased ReHo in the left insula and right caudate. Through further seed-based FC analysis, we found decreased FC between the left insula and left precentral gyrus in patients with RRMS compared with HCs, as well as increased FC between the right caudate and right dorsolateral prefrontal cortex. Pearson’s correlation analysis showed that a decreased ReHo value in the left insula was associated with an increased total white matter lesion loads (TWMLL) score (r=-0.594, P=0.004) or a worsened paced auditory serial addition test score (r=0.536, P=0.010). No other significant correlations were observed between the FC value (left insula - left precentral gyrus) and clinical scores (P=0.246–0.982). The ReHo value of the right caudate was negatively correlated with disease duration (r=-0.526, P=0.012) and with the TWMLL score (r=-0.596, P=0.003). Moreover, a positive correlation was observed between the FC value (right caudate - right dorsolateral prefrontal cortex) and the TWMLL score (r=0.523, P=0.012) or the modified fatigue impact scale-5 score (r=0.608, P=0.003). Conclusion: Together, these findings suggest that the insula with regional dysfunction involves disconnection with sensorimotor regions, and demyelinating lesion-related intra- and interregional dysfunction in the caudate is associated with the impact of fatigue on cognitive control functions. Abnormal synchronization of intra- and interregional activity in the insula and caudate may play important roles in the pathology of RRMS. Keywords: relapsing–remitting multiple sclerosis, functional MRI, resting state, regional homogeneity, functional connectivity, caudate, insulaWu LZhang YZhou FGao LHe LZeng XGong HDove Medical Pressarticlerelapsing-remitting multiple sclerosisfunctional MRIresting-stateregional homogeneityfunctional connectivityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 853-862 (2016)
institution DOAJ
collection DOAJ
language EN
topic relapsing-remitting multiple sclerosis
functional MRI
resting-state
regional homogeneity
functional connectivity
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle relapsing-remitting multiple sclerosis
functional MRI
resting-state
regional homogeneity
functional connectivity
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Wu L
Zhang Y
Zhou F
Gao L
He L
Zeng X
Gong H
Altered intra- and interregional synchronization in relapsing–remitting multiple sclerosis: a resting-state fMRI study
description Lin Wu,1,2,* Yue Zhang,3,* Fuqing Zhou,1,2,* Lei Gao,2 Laichang He,1,2 Xianjun Zeng,1,2 Honghan Gong1,2 1Department of Radiology, The First Affiliated Hospital, Nanchang University, 2Jiangxi Province Medical Imaging Research Institute, 3Department of Radiology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, People’s Republic of China *These authors contributed equally to this work Background and purpose: Neuroimaging studies of relapsing–remitting multiple sclerosis (RRMS) have found structural disconnection and large-scale neural network dysfunction. However, few studies have explored the local brain activity of RRMS patients in the resting state. Patients and methods: In this study, regional homogeneity (ReHo) and resting-state functional connectivity (FC) were used to investigate intra- and interregional synchronized activity in 22 patients with RRMS and 22 matched healthy controls (HCs). Results: Compared with HCs, patients with RRMS showed significantly decreased ReHo in the left insula and right caudate. Through further seed-based FC analysis, we found decreased FC between the left insula and left precentral gyrus in patients with RRMS compared with HCs, as well as increased FC between the right caudate and right dorsolateral prefrontal cortex. Pearson’s correlation analysis showed that a decreased ReHo value in the left insula was associated with an increased total white matter lesion loads (TWMLL) score (r=-0.594, P=0.004) or a worsened paced auditory serial addition test score (r=0.536, P=0.010). No other significant correlations were observed between the FC value (left insula - left precentral gyrus) and clinical scores (P=0.246–0.982). The ReHo value of the right caudate was negatively correlated with disease duration (r=-0.526, P=0.012) and with the TWMLL score (r=-0.596, P=0.003). Moreover, a positive correlation was observed between the FC value (right caudate - right dorsolateral prefrontal cortex) and the TWMLL score (r=0.523, P=0.012) or the modified fatigue impact scale-5 score (r=0.608, P=0.003). Conclusion: Together, these findings suggest that the insula with regional dysfunction involves disconnection with sensorimotor regions, and demyelinating lesion-related intra- and interregional dysfunction in the caudate is associated with the impact of fatigue on cognitive control functions. Abnormal synchronization of intra- and interregional activity in the insula and caudate may play important roles in the pathology of RRMS. Keywords: relapsing–remitting multiple sclerosis, functional MRI, resting state, regional homogeneity, functional connectivity, caudate, insula
format article
author Wu L
Zhang Y
Zhou F
Gao L
He L
Zeng X
Gong H
author_facet Wu L
Zhang Y
Zhou F
Gao L
He L
Zeng X
Gong H
author_sort Wu L
title Altered intra- and interregional synchronization in relapsing–remitting multiple sclerosis: a resting-state fMRI study
title_short Altered intra- and interregional synchronization in relapsing–remitting multiple sclerosis: a resting-state fMRI study
title_full Altered intra- and interregional synchronization in relapsing–remitting multiple sclerosis: a resting-state fMRI study
title_fullStr Altered intra- and interregional synchronization in relapsing–remitting multiple sclerosis: a resting-state fMRI study
title_full_unstemmed Altered intra- and interregional synchronization in relapsing–remitting multiple sclerosis: a resting-state fMRI study
title_sort altered intra- and interregional synchronization in relapsing–remitting multiple sclerosis: a resting-state fmri study
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/ade6db5734d2476a9df641bff02c1527
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