Viral Myocarditis—From Pathophysiology to Treatment

The diagnosis of acute and chronic myocarditis remains a challenge for clinicians. Characterization of this disease has been hampered by its diverse etiologies and heterogeneous clinical presentations. Most cases of myocarditis are caused by infectious agents. Despite successful research in the last...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Heinz-Peter Schultheiss, Christian Baumeier, Ganna Aleshcheva, C.-Thomas Bock, Felicitas Escher
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	viral myocarditis autoimmunity dilated cardiomyopathy pathophysiology endomyocardial biopsy therapeutic approach Medicine R
Acceso en línea:	https://doaj.org/article/ade72ae2107b4e46b9ef1710fb83763d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ade72ae2107b4e46b9ef1710fb83763d
record_format	dspace
spelling	oai:doaj.org-article:ade72ae2107b4e46b9ef1710fb83763d2021-11-25T18:00:47ZViral Myocarditis—From Pathophysiology to Treatment10.3390/jcm102252402077-0383https://doaj.org/article/ade72ae2107b4e46b9ef1710fb83763d2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5240https://doaj.org/toc/2077-0383The diagnosis of acute and chronic myocarditis remains a challenge for clinicians. Characterization of this disease has been hampered by its diverse etiologies and heterogeneous clinical presentations. Most cases of myocarditis are caused by infectious agents. Despite successful research in the last few years, the pathophysiology of viral myocarditis and its sequelae leading to severe heart failure with a poor prognosis is not fully understood and represents a significant public health issue globally. Most likely, at a certain point, besides viral persistence, several etiological types merge into a common pathogenic autoimmune process leading to chronic inflammation and tissue remodeling, ultimately resulting in the clinical phenotype of dilated cardiomyopathy. Understanding the underlying molecular mechanisms is necessary to assess the prognosis of patients and is fundamental to appropriate specific and personalized therapeutic strategies. To reach this clinical prerequisite, there is the need for advanced diagnostic tools, including an endomyocardial biopsy and guidelines to optimize the management of this disease. The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has currently led to the worst pandemic in a century and has awakened a special sensitivity throughout the world to viral infections. This work aims to summarize the pathophysiology of viral myocarditis, advanced diagnostic methods and the current state of treatment options.Heinz-Peter SchultheissChristian BaumeierGanna AleshchevaC.-Thomas BockFelicitas EscherMDPI AGarticleviral myocarditisautoimmunitydilated cardiomyopathypathophysiologyendomyocardial biopsytherapeutic approachMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5240, p 5240 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	viral myocarditis autoimmunity dilated cardiomyopathy pathophysiology endomyocardial biopsy therapeutic approach Medicine R
spellingShingle	viral myocarditis autoimmunity dilated cardiomyopathy pathophysiology endomyocardial biopsy therapeutic approach Medicine R Heinz-Peter Schultheiss Christian Baumeier Ganna Aleshcheva C.-Thomas Bock Felicitas Escher Viral Myocarditis—From Pathophysiology to Treatment
description	The diagnosis of acute and chronic myocarditis remains a challenge for clinicians. Characterization of this disease has been hampered by its diverse etiologies and heterogeneous clinical presentations. Most cases of myocarditis are caused by infectious agents. Despite successful research in the last few years, the pathophysiology of viral myocarditis and its sequelae leading to severe heart failure with a poor prognosis is not fully understood and represents a significant public health issue globally. Most likely, at a certain point, besides viral persistence, several etiological types merge into a common pathogenic autoimmune process leading to chronic inflammation and tissue remodeling, ultimately resulting in the clinical phenotype of dilated cardiomyopathy. Understanding the underlying molecular mechanisms is necessary to assess the prognosis of patients and is fundamental to appropriate specific and personalized therapeutic strategies. To reach this clinical prerequisite, there is the need for advanced diagnostic tools, including an endomyocardial biopsy and guidelines to optimize the management of this disease. The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has currently led to the worst pandemic in a century and has awakened a special sensitivity throughout the world to viral infections. This work aims to summarize the pathophysiology of viral myocarditis, advanced diagnostic methods and the current state of treatment options.
format	article
author	Heinz-Peter Schultheiss Christian Baumeier Ganna Aleshcheva C.-Thomas Bock Felicitas Escher
author_facet	Heinz-Peter Schultheiss Christian Baumeier Ganna Aleshcheva C.-Thomas Bock Felicitas Escher
author_sort	Heinz-Peter Schultheiss
title	Viral Myocarditis—From Pathophysiology to Treatment
title_short	Viral Myocarditis—From Pathophysiology to Treatment
title_full	Viral Myocarditis—From Pathophysiology to Treatment
title_fullStr	Viral Myocarditis—From Pathophysiology to Treatment
title_full_unstemmed	Viral Myocarditis—From Pathophysiology to Treatment
title_sort	viral myocarditis—from pathophysiology to treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ade72ae2107b4e46b9ef1710fb83763d
work_keys_str_mv	AT heinzpeterschultheiss viralmyocarditisfrompathophysiologytotreatment AT christianbaumeier viralmyocarditisfrompathophysiologytotreatment AT gannaaleshcheva viralmyocarditisfrompathophysiologytotreatment AT cthomasbock viralmyocarditisfrompathophysiologytotreatment AT felicitasescher viralmyocarditisfrompathophysiologytotreatment
_version_	1718411765402828800

Viral Myocarditis—From Pathophysiology to Treatment

Ejemplares similares