Impacts of Early Life Stress on the Methylome and Transcriptome of Atlantic Salmon

Abstract Exposure to environmental stressors during early-life stages can change the rate and timing of various developmental processes. Epigenetic marks affecting transcriptional regulation can be altered by such environmental stimuli. To assess how stress might affect the methylome and transcripto...

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Autores principales:	Hooman K. Moghadam, Hanne Johnsen, Nicholas Robinson, Øivind Andersen, Even H. Jørgensen, Helge K. Johnsen, Vegar J. Bæhr, Helge Tveiten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ade962a720de4570a581d9ad8a132ebe
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spelling	oai:doaj.org-article:ade962a720de4570a581d9ad8a132ebe2021-12-02T16:06:47ZImpacts of Early Life Stress on the Methylome and Transcriptome of Atlantic Salmon10.1038/s41598-017-05222-22045-2322https://doaj.org/article/ade962a720de4570a581d9ad8a132ebe2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05222-2https://doaj.org/toc/2045-2322Abstract Exposure to environmental stressors during early-life stages can change the rate and timing of various developmental processes. Epigenetic marks affecting transcriptional regulation can be altered by such environmental stimuli. To assess how stress might affect the methylome and transcriptome in salmon, fish were treated using cold-shock and air-exposure from the eye-stage until start-feeding. The fish were either stressed prior to hatching (E), post-hatching (PH), pre- and post-hatching (EPH) or not stressed (CO). Assessing transcriptional abundances just prior to start feeding, E and PH individuals were found to have modified the expression of thousands of genes, many with important functions in developmental processes. The EPH individuals however, showed expression similar to those of CO, suggesting an adaptive response to extended periods of stress. The methylome of stressed individuals differed from that of the CO, suggesting the importance of environment in shaping methylation signatures. Through integration of methylation with transcription, we identified bases with potential regulatory functions, some 10s of kb away from the targeted genes. We then followed fish growth for an additional year. Individuals in EPH showed superior growth compared to other treatment groups, highlighting how stress can potentially have long-lasting effects on an organism’s ability to adapt to environmental perturbations.Hooman K. MoghadamHanne JohnsenNicholas RobinsonØivind AndersenEven H. JørgensenHelge K. JohnsenVegar J. BæhrHelge TveitenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hooman K. Moghadam Hanne Johnsen Nicholas Robinson Øivind Andersen Even H. Jørgensen Helge K. Johnsen Vegar J. Bæhr Helge Tveiten Impacts of Early Life Stress on the Methylome and Transcriptome of Atlantic Salmon
description	Abstract Exposure to environmental stressors during early-life stages can change the rate and timing of various developmental processes. Epigenetic marks affecting transcriptional regulation can be altered by such environmental stimuli. To assess how stress might affect the methylome and transcriptome in salmon, fish were treated using cold-shock and air-exposure from the eye-stage until start-feeding. The fish were either stressed prior to hatching (E), post-hatching (PH), pre- and post-hatching (EPH) or not stressed (CO). Assessing transcriptional abundances just prior to start feeding, E and PH individuals were found to have modified the expression of thousands of genes, many with important functions in developmental processes. The EPH individuals however, showed expression similar to those of CO, suggesting an adaptive response to extended periods of stress. The methylome of stressed individuals differed from that of the CO, suggesting the importance of environment in shaping methylation signatures. Through integration of methylation with transcription, we identified bases with potential regulatory functions, some 10s of kb away from the targeted genes. We then followed fish growth for an additional year. Individuals in EPH showed superior growth compared to other treatment groups, highlighting how stress can potentially have long-lasting effects on an organism’s ability to adapt to environmental perturbations.
format	article
author	Hooman K. Moghadam Hanne Johnsen Nicholas Robinson Øivind Andersen Even H. Jørgensen Helge K. Johnsen Vegar J. Bæhr Helge Tveiten
author_facet	Hooman K. Moghadam Hanne Johnsen Nicholas Robinson Øivind Andersen Even H. Jørgensen Helge K. Johnsen Vegar J. Bæhr Helge Tveiten
author_sort	Hooman K. Moghadam
title	Impacts of Early Life Stress on the Methylome and Transcriptome of Atlantic Salmon
title_short	Impacts of Early Life Stress on the Methylome and Transcriptome of Atlantic Salmon
title_full	Impacts of Early Life Stress on the Methylome and Transcriptome of Atlantic Salmon
title_fullStr	Impacts of Early Life Stress on the Methylome and Transcriptome of Atlantic Salmon
title_full_unstemmed	Impacts of Early Life Stress on the Methylome and Transcriptome of Atlantic Salmon
title_sort	impacts of early life stress on the methylome and transcriptome of atlantic salmon
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ade962a720de4570a581d9ad8a132ebe
work_keys_str_mv	AT hoomankmoghadam impactsofearlylifestressonthemethylomeandtranscriptomeofatlanticsalmon AT hannejohnsen impactsofearlylifestressonthemethylomeandtranscriptomeofatlanticsalmon AT nicholasrobinson impactsofearlylifestressonthemethylomeandtranscriptomeofatlanticsalmon AT øivindandersen impactsofearlylifestressonthemethylomeandtranscriptomeofatlanticsalmon AT evenhjørgensen impactsofearlylifestressonthemethylomeandtranscriptomeofatlanticsalmon AT helgekjohnsen impactsofearlylifestressonthemethylomeandtranscriptomeofatlanticsalmon AT vegarjbæhr impactsofearlylifestressonthemethylomeandtranscriptomeofatlanticsalmon AT helgetveiten impactsofearlylifestressonthemethylomeandtranscriptomeofatlanticsalmon
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Impacts of Early Life Stress on the Methylome and Transcriptome of Atlantic Salmon

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