High Prevalence of Depressive Symptoms Among Ugandan Patients with Rheumatoid Arthritis

Felix Bongomin,1,2 Barbra Natukunda,1 Maria Sekimpi,1 Ronald Olum,1 Joseph Baruch Baluku,3,4 Anthony Makhoba,5,6 Mark Kaddumukasa1 1Department of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; 2Department of Immunology and Medical Microbiology, Gulu University Medical Sc...

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Autores principales: Bongomin F, Natukunda B, Sekimpi M, Olum R, Baluku JB, Makhoba A, Kaddumukasa M
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Publicado: Dove Medical Press 2021
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spelling oai:doaj.org-article:adec3a1dd17b44549ab5e283ec169e4e2021-12-02T17:01:03ZHigh Prevalence of Depressive Symptoms Among Ugandan Patients with Rheumatoid Arthritis1179-156Xhttps://doaj.org/article/adec3a1dd17b44549ab5e283ec169e4e2021-05-01T00:00:00Zhttps://www.dovepress.com/high-prevalence-of-depressive-symptoms-among-ugandan-patients-with-rhe-peer-reviewed-fulltext-article-OARRRhttps://doaj.org/toc/1179-156XFelix Bongomin,1,2 Barbra Natukunda,1 Maria Sekimpi,1 Ronald Olum,1 Joseph Baruch Baluku,3,4 Anthony Makhoba,5,6 Mark Kaddumukasa1 1Department of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; 2Department of Immunology and Medical Microbiology, Gulu University Medical School, Gulu, Uganda; 3Division of Pulmonology, Mulago National Referral Hospital, Kampala, Uganda; 4Directorate of Programs, Mildmay Uganda, Wakiso, Uganda; 5Department of Medicine, St. Francis’s Hospital- Nsambya, Kampala, Uganda; 6Department of Medicine, Mother Kevin Postgraduate Medical School, Uganda Martyrs University, Kampala, UgandaCorrespondence: Felix BongominDepartment of Medicine, College of Health Sciences, Makerere University, Kampala, UgandaTel +256 784-523-395Email drbongomin@gmail.comBackground: There is a scarcity of data on the burden of depression among Ugandans with rheumatoid arthritis (RA) patients. We aimed to screen for symptoms of depression, their severity and associated factors among patients with RA in Uganda.Patients and Methods: A descriptive, cross-sectional study was conducted between September and December 2020 at Mulago National Referral Hospital (MNRH) and Nsambya Hospital. Patients with RA were enrolled consecutively. Data on demographics, disease course and comorbidities and depression symptomatology were collected through an interviewer administered questionnaire. Symptoms of depression were screened for using the depression/anxiety dimension of the EuroQoL questionnaire.Results: Forty-eight patients with a median age of 52 (IQR: 43.5– 60.5) years were recruited in the study. The majority of the patients were female (91.7%, n=44). Twenty-nine patients (60.4%) had comorbidities with a median Charlson comorbidity score of 3 (IQR: 2– 4). Overall, 70.8% (n=34) had depressive symptoms. Patients attending MNRH were more likely to have depressive symptoms (p=0.025). Significantly, patients with depressive symptoms were younger (p=0.027), had lower health index value (p< 0.001), and lower overall self-reported health status (p=0.013). At binary logistic regression, patients at MNRH (crude odds ratio (COR): 4.32, 95% confidence interval (CI): 1.16– 16.15, P=0.030), patients aged < 52 years (COR: 5.24, 95% CI: 1.23– 22.28, P=0.025) and those with mild RA (COR: 5.71, 95% CI: 1.15– 28.35, P=0.033) were significantly more likely to have depressive symptoms. Increase in age (COR: 0.94, 95% CI: 0.89– 0.99, P=0.025), and high visual analogue score (COR: 0.94, 95% CI: 0.89– 0.99, P=0.013) were protective.Conclusion: Depressive symptoms were common among RA patients in Uganda. Routine screening, diagnosis and management of depression is recommended among young patients to improve quality of life and patient outcomes.Keywords: rheumatoid arthritis, depression, ED-5D-5L, UgandaBongomin FNatukunda BSekimpi MOlum RBaluku JBMakhoba AKaddumukasa MDove Medical Pressarticlerheumatoid arthritisdepressioned-5d-5lugandaDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 13, Pp 93-102 (2021)
institution DOAJ
collection DOAJ
language EN
topic rheumatoid arthritis
depression
ed-5d-5l
uganda
Diseases of the musculoskeletal system
RC925-935
spellingShingle rheumatoid arthritis
depression
ed-5d-5l
uganda
Diseases of the musculoskeletal system
RC925-935
Bongomin F
Natukunda B
Sekimpi M
Olum R
Baluku JB
Makhoba A
Kaddumukasa M
High Prevalence of Depressive Symptoms Among Ugandan Patients with Rheumatoid Arthritis
description Felix Bongomin,1,2 Barbra Natukunda,1 Maria Sekimpi,1 Ronald Olum,1 Joseph Baruch Baluku,3,4 Anthony Makhoba,5,6 Mark Kaddumukasa1 1Department of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; 2Department of Immunology and Medical Microbiology, Gulu University Medical School, Gulu, Uganda; 3Division of Pulmonology, Mulago National Referral Hospital, Kampala, Uganda; 4Directorate of Programs, Mildmay Uganda, Wakiso, Uganda; 5Department of Medicine, St. Francis’s Hospital- Nsambya, Kampala, Uganda; 6Department of Medicine, Mother Kevin Postgraduate Medical School, Uganda Martyrs University, Kampala, UgandaCorrespondence: Felix BongominDepartment of Medicine, College of Health Sciences, Makerere University, Kampala, UgandaTel +256 784-523-395Email drbongomin@gmail.comBackground: There is a scarcity of data on the burden of depression among Ugandans with rheumatoid arthritis (RA) patients. We aimed to screen for symptoms of depression, their severity and associated factors among patients with RA in Uganda.Patients and Methods: A descriptive, cross-sectional study was conducted between September and December 2020 at Mulago National Referral Hospital (MNRH) and Nsambya Hospital. Patients with RA were enrolled consecutively. Data on demographics, disease course and comorbidities and depression symptomatology were collected through an interviewer administered questionnaire. Symptoms of depression were screened for using the depression/anxiety dimension of the EuroQoL questionnaire.Results: Forty-eight patients with a median age of 52 (IQR: 43.5– 60.5) years were recruited in the study. The majority of the patients were female (91.7%, n=44). Twenty-nine patients (60.4%) had comorbidities with a median Charlson comorbidity score of 3 (IQR: 2– 4). Overall, 70.8% (n=34) had depressive symptoms. Patients attending MNRH were more likely to have depressive symptoms (p=0.025). Significantly, patients with depressive symptoms were younger (p=0.027), had lower health index value (p< 0.001), and lower overall self-reported health status (p=0.013). At binary logistic regression, patients at MNRH (crude odds ratio (COR): 4.32, 95% confidence interval (CI): 1.16– 16.15, P=0.030), patients aged < 52 years (COR: 5.24, 95% CI: 1.23– 22.28, P=0.025) and those with mild RA (COR: 5.71, 95% CI: 1.15– 28.35, P=0.033) were significantly more likely to have depressive symptoms. Increase in age (COR: 0.94, 95% CI: 0.89– 0.99, P=0.025), and high visual analogue score (COR: 0.94, 95% CI: 0.89– 0.99, P=0.013) were protective.Conclusion: Depressive symptoms were common among RA patients in Uganda. Routine screening, diagnosis and management of depression is recommended among young patients to improve quality of life and patient outcomes.Keywords: rheumatoid arthritis, depression, ED-5D-5L, Uganda
format article
author Bongomin F
Natukunda B
Sekimpi M
Olum R
Baluku JB
Makhoba A
Kaddumukasa M
author_facet Bongomin F
Natukunda B
Sekimpi M
Olum R
Baluku JB
Makhoba A
Kaddumukasa M
author_sort Bongomin F
title High Prevalence of Depressive Symptoms Among Ugandan Patients with Rheumatoid Arthritis
title_short High Prevalence of Depressive Symptoms Among Ugandan Patients with Rheumatoid Arthritis
title_full High Prevalence of Depressive Symptoms Among Ugandan Patients with Rheumatoid Arthritis
title_fullStr High Prevalence of Depressive Symptoms Among Ugandan Patients with Rheumatoid Arthritis
title_full_unstemmed High Prevalence of Depressive Symptoms Among Ugandan Patients with Rheumatoid Arthritis
title_sort high prevalence of depressive symptoms among ugandan patients with rheumatoid arthritis
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/adec3a1dd17b44549ab5e283ec169e4e
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