Association between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study

Abstract Social inequalities in health and disease are well studied. Less information is available on inequalities in biomarker levels indicating subclinical stages of disease such as cystatin C, an early diagnostic marker of renal dysfunction and predictor for cardiovascular disease. We evaluated t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tanja Zamrik, Mirjam Frank, Carina Emmel, Lars Christian Rump, Raimund Erbel, Karl-Heinz Jöckel, Nico Dragano, Börge Schmidt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/adec8468a5cd47e18d3fe113a97588f7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:adec8468a5cd47e18d3fe113a97588f7
record_format	dspace
spelling	oai:doaj.org-article:adec8468a5cd47e18d3fe113a97588f72021-12-02T18:51:28ZAssociation between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study10.1038/s41598-021-98835-72045-2322https://doaj.org/article/adec8468a5cd47e18d3fe113a97588f72021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98835-7https://doaj.org/toc/2045-2322Abstract Social inequalities in health and disease are well studied. Less information is available on inequalities in biomarker levels indicating subclinical stages of disease such as cystatin C, an early diagnostic marker of renal dysfunction and predictor for cardiovascular disease. We evaluated the relationship between cystatin C, socioeconomic position (SEP) and established cardiovascular risk factors in a population-based study. In 4475 men and women aged 45–75 years participating in the baseline examination of the Heinz Nixdorf Recall Study cystatin C was measured from serum samples with a nephelometric assay. SEP was assessed by education and household income. Linear regression models were used to analyse the association between SEP and cystatin C as well as the impact of cardiovascular risk factors (i.e., body mass index, blood pressure, blood glucose, diabetes mellitus, blood lipids, C-reactive protein, smoking) on this association. After adjustment for age and sex cystatin C decreased by 0.019 mg/l (95% confidence interval (CI) − 0.030 to − 0.008) per five years of education. While using a categorical education variable cystatin C presented 0.039 mg/l (95% CI 0.017–0.061) higher in men and women in the lowest educational category (≤ 10 years of education) compared to the highest category (≥ 18 years). Concerning income, cystatin C decreased by 0.014 mg/l (95% CI − 0.021 to − 0.006) per 1000 € after adjustment for age and sex. For men and women in the lowest income quartile cystatin C was 0.024 mg/l (95% CI 0.009–0.038) higher compared to the highest income quartile. After adjusting for established cardiovascular risk factors the observed associations were substantially diminished. Social inequalities seem to play a role in subclinical stages of renal dysfunction, which are also related to development of cardiovascular disease. Adjustment for traditional cardiovascular risk factors showed that these risk factors largely explain the association between SEP and cystatin C.Tanja ZamrikMirjam FrankCarina EmmelLars Christian RumpRaimund ErbelKarl-Heinz JöckelNico DraganoBörge SchmidtNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tanja Zamrik Mirjam Frank Carina Emmel Lars Christian Rump Raimund Erbel Karl-Heinz Jöckel Nico Dragano Börge Schmidt Association between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study
description	Abstract Social inequalities in health and disease are well studied. Less information is available on inequalities in biomarker levels indicating subclinical stages of disease such as cystatin C, an early diagnostic marker of renal dysfunction and predictor for cardiovascular disease. We evaluated the relationship between cystatin C, socioeconomic position (SEP) and established cardiovascular risk factors in a population-based study. In 4475 men and women aged 45–75 years participating in the baseline examination of the Heinz Nixdorf Recall Study cystatin C was measured from serum samples with a nephelometric assay. SEP was assessed by education and household income. Linear regression models were used to analyse the association between SEP and cystatin C as well as the impact of cardiovascular risk factors (i.e., body mass index, blood pressure, blood glucose, diabetes mellitus, blood lipids, C-reactive protein, smoking) on this association. After adjustment for age and sex cystatin C decreased by 0.019 mg/l (95% confidence interval (CI) − 0.030 to − 0.008) per five years of education. While using a categorical education variable cystatin C presented 0.039 mg/l (95% CI 0.017–0.061) higher in men and women in the lowest educational category (≤ 10 years of education) compared to the highest category (≥ 18 years). Concerning income, cystatin C decreased by 0.014 mg/l (95% CI − 0.021 to − 0.006) per 1000 € after adjustment for age and sex. For men and women in the lowest income quartile cystatin C was 0.024 mg/l (95% CI 0.009–0.038) higher compared to the highest income quartile. After adjusting for established cardiovascular risk factors the observed associations were substantially diminished. Social inequalities seem to play a role in subclinical stages of renal dysfunction, which are also related to development of cardiovascular disease. Adjustment for traditional cardiovascular risk factors showed that these risk factors largely explain the association between SEP and cystatin C.
format	article
author	Tanja Zamrik Mirjam Frank Carina Emmel Lars Christian Rump Raimund Erbel Karl-Heinz Jöckel Nico Dragano Börge Schmidt
author_facet	Tanja Zamrik Mirjam Frank Carina Emmel Lars Christian Rump Raimund Erbel Karl-Heinz Jöckel Nico Dragano Börge Schmidt
author_sort	Tanja Zamrik
title	Association between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study
title_short	Association between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study
title_full	Association between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study
title_fullStr	Association between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study
title_full_unstemmed	Association between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study
title_sort	association between socioeconomic position and cystatin c in the heinz nixdorf recall study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/adec8468a5cd47e18d3fe113a97588f7
work_keys_str_mv	AT tanjazamrik associationbetweensocioeconomicpositionandcystatincintheheinznixdorfrecallstudy AT mirjamfrank associationbetweensocioeconomicpositionandcystatincintheheinznixdorfrecallstudy AT carinaemmel associationbetweensocioeconomicpositionandcystatincintheheinznixdorfrecallstudy AT larschristianrump associationbetweensocioeconomicpositionandcystatincintheheinznixdorfrecallstudy AT raimunderbel associationbetweensocioeconomicpositionandcystatincintheheinznixdorfrecallstudy AT karlheinzjockel associationbetweensocioeconomicpositionandcystatincintheheinznixdorfrecallstudy AT nicodragano associationbetweensocioeconomicpositionandcystatincintheheinznixdorfrecallstudy AT borgeschmidt associationbetweensocioeconomicpositionandcystatincintheheinznixdorfrecallstudy
_version_	1718377404204843008

Association between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study

Ejemplares similares