YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis
The molecular mechanisms driving proliferation in the pediatric brain cancer epdendymoma are poorly understood. Here the authors show that a YAP1- MAMLD1 fusion drives tumor formation in mice and show that the fusion protein can collaborate with the TEAD and NFI transcription factors.
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Nature Portfolio
2019
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oai:doaj.org-article:adf1b461d84d45cc809ee416ce32b2412021-12-02T17:31:37ZYAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis10.1038/s41467-019-11884-52041-1723https://doaj.org/article/adf1b461d84d45cc809ee416ce32b2412019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11884-5https://doaj.org/toc/2041-1723The molecular mechanisms driving proliferation in the pediatric brain cancer epdendymoma are poorly understood. Here the authors show that a YAP1- MAMLD1 fusion drives tumor formation in mice and show that the fusion protein can collaborate with the TEAD and NFI transcription factors.Kristian W. PajtlerYiju WeiKonstantin OkonechnikovPatricia B. G. SilvaMikaella VouriLei ZhangSebastian BrabetzLaura SieberMelissa GulleyMonika MauermannTatjana WedigNorman MackYuka Imamura KawasawaTanvi SharmaMarc ZuckermannFelipe AndreiuoloEric HollandKendra MaassHuiqin Körkel-QuHai-Kun LiuFelix SahmDavid CapperJens BuntLinda J. RichardsDavid T. W. JonesAndrey KorshunovLukas ChavezPeter LichterMikio HoshinoStefan M. PfisterMarcel KoolWei LiDaisuke KawauchiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Kristian W. Pajtler Yiju Wei Konstantin Okonechnikov Patricia B. G. Silva Mikaella Vouri Lei Zhang Sebastian Brabetz Laura Sieber Melissa Gulley Monika Mauermann Tatjana Wedig Norman Mack Yuka Imamura Kawasawa Tanvi Sharma Marc Zuckermann Felipe Andreiuolo Eric Holland Kendra Maass Huiqin Körkel-Qu Hai-Kun Liu Felix Sahm David Capper Jens Bunt Linda J. Richards David T. W. Jones Andrey Korshunov Lukas Chavez Peter Lichter Mikio Hoshino Stefan M. Pfister Marcel Kool Wei Li Daisuke Kawauchi YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis |
| description |
The molecular mechanisms driving proliferation in the pediatric brain cancer epdendymoma are poorly understood. Here the authors show that a YAP1- MAMLD1 fusion drives tumor formation in mice and show that the fusion protein can collaborate with the TEAD and NFI transcription factors. |
| format |
article |
| author |
Kristian W. Pajtler Yiju Wei Konstantin Okonechnikov Patricia B. G. Silva Mikaella Vouri Lei Zhang Sebastian Brabetz Laura Sieber Melissa Gulley Monika Mauermann Tatjana Wedig Norman Mack Yuka Imamura Kawasawa Tanvi Sharma Marc Zuckermann Felipe Andreiuolo Eric Holland Kendra Maass Huiqin Körkel-Qu Hai-Kun Liu Felix Sahm David Capper Jens Bunt Linda J. Richards David T. W. Jones Andrey Korshunov Lukas Chavez Peter Lichter Mikio Hoshino Stefan M. Pfister Marcel Kool Wei Li Daisuke Kawauchi |
| author_facet |
Kristian W. Pajtler Yiju Wei Konstantin Okonechnikov Patricia B. G. Silva Mikaella Vouri Lei Zhang Sebastian Brabetz Laura Sieber Melissa Gulley Monika Mauermann Tatjana Wedig Norman Mack Yuka Imamura Kawasawa Tanvi Sharma Marc Zuckermann Felipe Andreiuolo Eric Holland Kendra Maass Huiqin Körkel-Qu Hai-Kun Liu Felix Sahm David Capper Jens Bunt Linda J. Richards David T. W. Jones Andrey Korshunov Lukas Chavez Peter Lichter Mikio Hoshino Stefan M. Pfister Marcel Kool Wei Li Daisuke Kawauchi |
| author_sort |
Kristian W. Pajtler |
| title |
YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis |
| title_short |
YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis |
| title_full |
YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis |
| title_fullStr |
YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis |
| title_full_unstemmed |
YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis |
| title_sort |
yap1 subgroup supratentorial ependymoma requires tead and nuclear factor i-mediated transcriptional programmes for tumorigenesis |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/adf1b461d84d45cc809ee416ce32b241 |
| work_keys_str_mv |
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