Low SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown

Abstract We analyzed SARS-CoV-2 seroprevalence in a large, well-described representative Viennese cohort after an early governmental lockdown with respect to the occurrence of symptoms and household transmission. Participants of the LEAD Study, a population-based cohort study from Vienna, Austria, w...

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Autores principales:	Marie-Kathrin Breyer, Robab Breyer-Kohansal, Sylvia Hartl, Michael Kundi, Lukas Weseslindtner, Karin Stiasny, Elisabeth Puchhammer-Stöckl, Andrea Schrott, Manuela Födinger, Michael Binder, Markus Fiedler, Emiel F. M. Wouters, Otto C. Burghuber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/adf1e988826f4425893d29a06934e6f7
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spelling	oai:doaj.org-article:adf1e988826f4425893d29a06934e6f72021-12-02T15:55:21ZLow SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown10.1038/s41598-021-89711-52045-2322https://doaj.org/article/adf1e988826f4425893d29a06934e6f72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89711-5https://doaj.org/toc/2045-2322Abstract We analyzed SARS-CoV-2 seroprevalence in a large, well-described representative Viennese cohort after an early governmental lockdown with respect to the occurrence of symptoms and household transmission. Participants of the LEAD Study, a population-based cohort study from Vienna, Austria, were invited along with their household members (April 20th to May20th 2020). Sera were analyzed using anti-SARS-CoV-2 immunoassay including a neutralization test as a confirmatory assay. A total of 12,419 individuals participated (5984 LEAD participants; 6435 household members), 163 (1.31%; 59 LEAD cohort members) of whom were SARS-CoV-2 antibody positive. The estimated number of COVID-19 cases projected from our findings by age and sex for Vienna was 21,504 (1.13%). Cumulative number of positively tested cases in Vienna until May 20th 2020 was 3020, hence 7.1 times (95% confidence interval 5.5–9.1) lower than projected. Relative risk (RR) of seropositivity by age was highest for children aged 6–9 years [RR compared to age group 20–49: 1.21 (CI 0.37–4.01)], lowest for ≥ 65 years [RR 0.47 (CI 0.21–1.03)]. Half of the positive individuals developed no or mild symptoms. In a multivariate analysis, taste and smell disturbances were most strongly related to SARS-CoV-2 positivity. Infection probability within households with one confirmed SARS-CoV-2-specific antibody-positive person was 31%. Although seroprevalence was very low (1.13%) for a central European capital city, due to an early governmental lockdown, SARS-CoV-2 infections were more prevalent than officially reported polymerase chain reaction-positive cases. Of note, seroprevalence was highest in young children. Half of SARS-CoV-2 antibody-positive subjects had no or only mild symptoms. Taste and smell disturbances were most prominent, possibly guiding clinicians in diagnosing SARS-CoV-2 infection.Marie-Kathrin BreyerRobab Breyer-KohansalSylvia HartlMichael KundiLukas WeseslindtnerKarin StiasnyElisabeth Puchhammer-StöcklAndrea SchrottManuela FödingerMichael BinderMarkus FiedlerEmiel F. M. WoutersOtto C. BurghuberNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie-Kathrin Breyer Robab Breyer-Kohansal Sylvia Hartl Michael Kundi Lukas Weseslindtner Karin Stiasny Elisabeth Puchhammer-Stöckl Andrea Schrott Manuela Födinger Michael Binder Markus Fiedler Emiel F. M. Wouters Otto C. Burghuber Low SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown
description	Abstract We analyzed SARS-CoV-2 seroprevalence in a large, well-described representative Viennese cohort after an early governmental lockdown with respect to the occurrence of symptoms and household transmission. Participants of the LEAD Study, a population-based cohort study from Vienna, Austria, were invited along with their household members (April 20th to May20th 2020). Sera were analyzed using anti-SARS-CoV-2 immunoassay including a neutralization test as a confirmatory assay. A total of 12,419 individuals participated (5984 LEAD participants; 6435 household members), 163 (1.31%; 59 LEAD cohort members) of whom were SARS-CoV-2 antibody positive. The estimated number of COVID-19 cases projected from our findings by age and sex for Vienna was 21,504 (1.13%). Cumulative number of positively tested cases in Vienna until May 20th 2020 was 3020, hence 7.1 times (95% confidence interval 5.5–9.1) lower than projected. Relative risk (RR) of seropositivity by age was highest for children aged 6–9 years [RR compared to age group 20–49: 1.21 (CI 0.37–4.01)], lowest for ≥ 65 years [RR 0.47 (CI 0.21–1.03)]. Half of the positive individuals developed no or mild symptoms. In a multivariate analysis, taste and smell disturbances were most strongly related to SARS-CoV-2 positivity. Infection probability within households with one confirmed SARS-CoV-2-specific antibody-positive person was 31%. Although seroprevalence was very low (1.13%) for a central European capital city, due to an early governmental lockdown, SARS-CoV-2 infections were more prevalent than officially reported polymerase chain reaction-positive cases. Of note, seroprevalence was highest in young children. Half of SARS-CoV-2 antibody-positive subjects had no or only mild symptoms. Taste and smell disturbances were most prominent, possibly guiding clinicians in diagnosing SARS-CoV-2 infection.
format	article
author	Marie-Kathrin Breyer Robab Breyer-Kohansal Sylvia Hartl Michael Kundi Lukas Weseslindtner Karin Stiasny Elisabeth Puchhammer-Stöckl Andrea Schrott Manuela Födinger Michael Binder Markus Fiedler Emiel F. M. Wouters Otto C. Burghuber
author_facet	Marie-Kathrin Breyer Robab Breyer-Kohansal Sylvia Hartl Michael Kundi Lukas Weseslindtner Karin Stiasny Elisabeth Puchhammer-Stöckl Andrea Schrott Manuela Födinger Michael Binder Markus Fiedler Emiel F. M. Wouters Otto C. Burghuber
author_sort	Marie-Kathrin Breyer
title	Low SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown
title_short	Low SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown
title_full	Low SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown
title_fullStr	Low SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown
title_full_unstemmed	Low SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown
title_sort	low sars-cov-2 seroprevalence in the austrian capital after an early governmental lockdown
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/adf1e988826f4425893d29a06934e6f7
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Low SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown

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