Current knowledge on psoriasis and autoimmune diseases

Nilmarie Ayala-Fontánez,1,2 David C Soler,1,2 Thomas S McCormick1,2 1Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA; 2The Murdough Family Center for Psoriasis, University Hospitals Case Medical Center, Cleveland, OH, USA Abstract: Psoriasis is a prevalent,...

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Autores principales:	Ayala-Fontánez N, Soler DC, McCormick TS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Psoriasis Inflammation Autoimmune disease Comorbidity Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/adf4d6292d4e442a84783b2e0e213313
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spelling	oai:doaj.org-article:adf4d6292d4e442a84783b2e0e2133132021-12-02T05:10:16ZCurrent knowledge on psoriasis and autoimmune diseases2230-326Xhttps://doaj.org/article/adf4d6292d4e442a84783b2e0e2133132016-02-01T00:00:00Zhttps://www.dovepress.com/current-knowledge-on-psoriasis-and-autoimmune-diseases-peer-reviewed-article-PTThttps://doaj.org/toc/2230-326XNilmarie Ayala-Fontánez,1,2 David C Soler,1,2 Thomas S McCormick1,2 1Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA; 2The Murdough Family Center for Psoriasis, University Hospitals Case Medical Center, Cleveland, OH, USA Abstract: Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen presenting cells (APCs) and T cells. Exclusive cellular “responsibility” for the induction and maintenance of psoriatic plaques has not been clearly defined. Increased proliferation of keratinocytes and endothelial cells in conjunction with APC/T cell/monocyte/macrophage inflammation leads to the distinct epidermal and vascular hyperplasia that is characteristic of lesional psoriatic skin. Despite the identification of numerous susceptibility loci, no single genetic determinant has been identified as responsible for the induction of psoriasis. Thus, numerous other triggers of disease, such as environmental, microbial and complex cellular interactions must also be considered as participants in the development of this multifactorial disease. Recent advances in therapeutics, especially systemic so-called “biologics” have provided new hope for identifying the critical cellular targets that drive psoriasis pathogenesis. Recent recognition of the numerous co-morbidities and other autoimmune disorders associated with psoriasis, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus suggest common signaling elements and cellular mediators may direct disease pathogenesis. In this review, we discuss common cellular pathways and participants that mediate psoriasis and other autoimmune disorders that share these cellular signaling pathways. Keywords: psoriasis, autoimmunity, immunosuppressionAyala-Fontánez NSoler DCMcCormick TSDove Medical PressarticlePsoriasisInflammationAutoimmune diseaseComorbidityDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 7-32 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psoriasis Inflammation Autoimmune disease Comorbidity Dermatology RL1-803
spellingShingle	Psoriasis Inflammation Autoimmune disease Comorbidity Dermatology RL1-803 Ayala-Fontánez N Soler DC McCormick TS Current knowledge on psoriasis and autoimmune diseases
description	Nilmarie Ayala-Fontánez,1,2 David C Soler,1,2 Thomas S McCormick1,2 1Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA; 2The Murdough Family Center for Psoriasis, University Hospitals Case Medical Center, Cleveland, OH, USA Abstract: Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen presenting cells (APCs) and T cells. Exclusive cellular “responsibility” for the induction and maintenance of psoriatic plaques has not been clearly defined. Increased proliferation of keratinocytes and endothelial cells in conjunction with APC/T cell/monocyte/macrophage inflammation leads to the distinct epidermal and vascular hyperplasia that is characteristic of lesional psoriatic skin. Despite the identification of numerous susceptibility loci, no single genetic determinant has been identified as responsible for the induction of psoriasis. Thus, numerous other triggers of disease, such as environmental, microbial and complex cellular interactions must also be considered as participants in the development of this multifactorial disease. Recent advances in therapeutics, especially systemic so-called “biologics” have provided new hope for identifying the critical cellular targets that drive psoriasis pathogenesis. Recent recognition of the numerous co-morbidities and other autoimmune disorders associated with psoriasis, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus suggest common signaling elements and cellular mediators may direct disease pathogenesis. In this review, we discuss common cellular pathways and participants that mediate psoriasis and other autoimmune disorders that share these cellular signaling pathways. Keywords: psoriasis, autoimmunity, immunosuppression
format	article
author	Ayala-Fontánez N Soler DC McCormick TS
author_facet	Ayala-Fontánez N Soler DC McCormick TS
author_sort	Ayala-Fontánez N
title	Current knowledge on psoriasis and autoimmune diseases
title_short	Current knowledge on psoriasis and autoimmune diseases
title_full	Current knowledge on psoriasis and autoimmune diseases
title_fullStr	Current knowledge on psoriasis and autoimmune diseases
title_full_unstemmed	Current knowledge on psoriasis and autoimmune diseases
title_sort	current knowledge on psoriasis and autoimmune diseases
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/adf4d6292d4e442a84783b2e0e213313
work_keys_str_mv	AT ayalafontanezn currentknowledgeonpsoriasisandautoimmunediseases AT solerdc currentknowledgeonpsoriasisandautoimmunediseases AT mccormickts currentknowledgeonpsoriasisandautoimmunediseases
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Current knowledge on psoriasis and autoimmune diseases

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