Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.

Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid dec...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alicja Kuban-Jankowska, Jack A Tuszynski, Philip Winter, Magdalena Gorska, Narcyz Knap, Michal Wozniak
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/adf6ddcd969d42ac88d4b352b029f390
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:adf6ddcd969d42ac88d4b352b029f390
record_format	dspace
spelling	oai:doaj.org-article:adf6ddcd969d42ac88d4b352b029f3902021-11-18T08:03:30ZActivation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.1932-620310.1371/journal.pone.0052495https://doaj.org/article/adf6ddcd969d42ac88d4b352b029f3902012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300686/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid decreases the enzymatic activity of CD45 phosphatase significantly more than hydrogen peroxide. Our molecular docking computational analysis suggests that peroxytetradecanoic acid has a higher binding affinity to the catalytic center of CD45 than hydrogen peroxide.Alicja Kuban-JankowskaJack A TuszynskiPhilip WinterMagdalena GorskaNarcyz KnapMichal WozniakPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52495 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alicja Kuban-Jankowska Jack A Tuszynski Philip Winter Magdalena Gorska Narcyz Knap Michal Wozniak Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.
description	Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid decreases the enzymatic activity of CD45 phosphatase significantly more than hydrogen peroxide. Our molecular docking computational analysis suggests that peroxytetradecanoic acid has a higher binding affinity to the catalytic center of CD45 than hydrogen peroxide.
format	article
author	Alicja Kuban-Jankowska Jack A Tuszynski Philip Winter Magdalena Gorska Narcyz Knap Michal Wozniak
author_facet	Alicja Kuban-Jankowska Jack A Tuszynski Philip Winter Magdalena Gorska Narcyz Knap Michal Wozniak
author_sort	Alicja Kuban-Jankowska
title	Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.
title_short	Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.
title_full	Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.
title_fullStr	Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.
title_full_unstemmed	Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.
title_sort	activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase cd45.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/adf6ddcd969d42ac88d4b352b029f390
work_keys_str_mv	AT alicjakubanjankowska activationofhydrogenperoxidetoperoxytetradecanoicacidisresponsibleforpotentinhibitionofproteintyrosinephosphatasecd45 AT jackatuszynski activationofhydrogenperoxidetoperoxytetradecanoicacidisresponsibleforpotentinhibitionofproteintyrosinephosphatasecd45 AT philipwinter activationofhydrogenperoxidetoperoxytetradecanoicacidisresponsibleforpotentinhibitionofproteintyrosinephosphatasecd45 AT magdalenagorska activationofhydrogenperoxidetoperoxytetradecanoicacidisresponsibleforpotentinhibitionofproteintyrosinephosphatasecd45 AT narcyzknap activationofhydrogenperoxidetoperoxytetradecanoicacidisresponsibleforpotentinhibitionofproteintyrosinephosphatasecd45 AT michalwozniak activationofhydrogenperoxidetoperoxytetradecanoicacidisresponsibleforpotentinhibitionofproteintyrosinephosphatasecd45
_version_	1718422623954665472

Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.

Ejemplares similares