Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats.

<h4>Introduction</h4>Micronutrient deficiency is observed in heart failure patients. Taurine, for example, represents 50% of total free amino acids in the heart, and in vivo studies have linked taurine deficiency with cardiomyopathy.<h4>Methods</h4>Thirty-four male Wistar rat...

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Autores principales: Mariele Castilho Pansani, Paula S Azevedo, Bruna Paola Murino Rafacho, Marcos F Minicucci, Fernanda Chiuso-Minicucci, Sofia Gonçalves Zorzella-Pezavento, Julio Sergio Marchini, Gilberto João Padovan, Ana Angelica Henrique Fernandes, Beatriz B Matsubara, Luiz S Matsubara, Leonardo A M Zornoff, Sergio A R Paiva
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/adf7a0ecbccb41efafe7fc94daf9fbe5
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Sumario:<h4>Introduction</h4>Micronutrient deficiency is observed in heart failure patients. Taurine, for example, represents 50% of total free amino acids in the heart, and in vivo studies have linked taurine deficiency with cardiomyopathy.<h4>Methods</h4>Thirty-four male Wistar rats (body weight = 100 g) were weighed and randomly assigned to one of two groups: Control (C) or taurine-deficient (T (-)). Beta-alanine at a concentration of 3% was added to the animals' water to induce taurine deficiency in the T (-) group. On day 30, the rats were individually submitted to echocardiography; morphometrical and histopathological evaluation and metalloproteinase activity, oxidative stress and inflammation evaluation were performed. Tissue samples were collected to determine the taurine concentration in the heart.<h4>Results</h4>Taurine deficiency led to decreases in: ventricular wall thickness, left ventricle dry weight, myocyte sectional area, left ventricle posterior wall thickness and ventricular geometry. With regard to heart function, the velocity of the A wave, the ratio between the E and A wave, the ejection fraction, fractional shortening and cardiac output values were decreased in T (-) rats, suggesting abnormal diastolic and systolic function. Increased fibrosis, inflammation and increased activation of metalloproteinases were not observed. Oxidative stress was increased in deficient animals.<h4>Conclusions</h4>These data suggest that taurine deficiency promotes structural and functional cardiac alterations with unique characteristics.