Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats.
<h4>Introduction</h4>Micronutrient deficiency is observed in heart failure patients. Taurine, for example, represents 50% of total free amino acids in the heart, and in vivo studies have linked taurine deficiency with cardiomyopathy.<h4>Methods</h4>Thirty-four male Wistar rat...
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2012
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oai:doaj.org-article:adf7a0ecbccb41efafe7fc94daf9fbe52021-11-18T07:11:31ZAtrophic cardiac remodeling induced by taurine deficiency in Wistar rats.1932-620310.1371/journal.pone.0041439https://doaj.org/article/adf7a0ecbccb41efafe7fc94daf9fbe52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22844478/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Micronutrient deficiency is observed in heart failure patients. Taurine, for example, represents 50% of total free amino acids in the heart, and in vivo studies have linked taurine deficiency with cardiomyopathy.<h4>Methods</h4>Thirty-four male Wistar rats (body weight = 100 g) were weighed and randomly assigned to one of two groups: Control (C) or taurine-deficient (T (-)). Beta-alanine at a concentration of 3% was added to the animals' water to induce taurine deficiency in the T (-) group. On day 30, the rats were individually submitted to echocardiography; morphometrical and histopathological evaluation and metalloproteinase activity, oxidative stress and inflammation evaluation were performed. Tissue samples were collected to determine the taurine concentration in the heart.<h4>Results</h4>Taurine deficiency led to decreases in: ventricular wall thickness, left ventricle dry weight, myocyte sectional area, left ventricle posterior wall thickness and ventricular geometry. With regard to heart function, the velocity of the A wave, the ratio between the E and A wave, the ejection fraction, fractional shortening and cardiac output values were decreased in T (-) rats, suggesting abnormal diastolic and systolic function. Increased fibrosis, inflammation and increased activation of metalloproteinases were not observed. Oxidative stress was increased in deficient animals.<h4>Conclusions</h4>These data suggest that taurine deficiency promotes structural and functional cardiac alterations with unique characteristics.Mariele Castilho PansaniPaula S AzevedoBruna Paola Murino RafachoMarcos F MinicucciFernanda Chiuso-MinicucciSofia Gonçalves Zorzella-PezaventoJulio Sergio MarchiniGilberto João PadovanAna Angelica Henrique FernandesBeatriz B MatsubaraLuiz S MatsubaraLeonardo A M ZornoffSergio A R PaivaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41439 (2012) |
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Medicine R Science Q Mariele Castilho Pansani Paula S Azevedo Bruna Paola Murino Rafacho Marcos F Minicucci Fernanda Chiuso-Minicucci Sofia Gonçalves Zorzella-Pezavento Julio Sergio Marchini Gilberto João Padovan Ana Angelica Henrique Fernandes Beatriz B Matsubara Luiz S Matsubara Leonardo A M Zornoff Sergio A R Paiva Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats. |
| description |
<h4>Introduction</h4>Micronutrient deficiency is observed in heart failure patients. Taurine, for example, represents 50% of total free amino acids in the heart, and in vivo studies have linked taurine deficiency with cardiomyopathy.<h4>Methods</h4>Thirty-four male Wistar rats (body weight = 100 g) were weighed and randomly assigned to one of two groups: Control (C) or taurine-deficient (T (-)). Beta-alanine at a concentration of 3% was added to the animals' water to induce taurine deficiency in the T (-) group. On day 30, the rats were individually submitted to echocardiography; morphometrical and histopathological evaluation and metalloproteinase activity, oxidative stress and inflammation evaluation were performed. Tissue samples were collected to determine the taurine concentration in the heart.<h4>Results</h4>Taurine deficiency led to decreases in: ventricular wall thickness, left ventricle dry weight, myocyte sectional area, left ventricle posterior wall thickness and ventricular geometry. With regard to heart function, the velocity of the A wave, the ratio between the E and A wave, the ejection fraction, fractional shortening and cardiac output values were decreased in T (-) rats, suggesting abnormal diastolic and systolic function. Increased fibrosis, inflammation and increased activation of metalloproteinases were not observed. Oxidative stress was increased in deficient animals.<h4>Conclusions</h4>These data suggest that taurine deficiency promotes structural and functional cardiac alterations with unique characteristics. |
| format |
article |
| author |
Mariele Castilho Pansani Paula S Azevedo Bruna Paola Murino Rafacho Marcos F Minicucci Fernanda Chiuso-Minicucci Sofia Gonçalves Zorzella-Pezavento Julio Sergio Marchini Gilberto João Padovan Ana Angelica Henrique Fernandes Beatriz B Matsubara Luiz S Matsubara Leonardo A M Zornoff Sergio A R Paiva |
| author_facet |
Mariele Castilho Pansani Paula S Azevedo Bruna Paola Murino Rafacho Marcos F Minicucci Fernanda Chiuso-Minicucci Sofia Gonçalves Zorzella-Pezavento Julio Sergio Marchini Gilberto João Padovan Ana Angelica Henrique Fernandes Beatriz B Matsubara Luiz S Matsubara Leonardo A M Zornoff Sergio A R Paiva |
| author_sort |
Mariele Castilho Pansani |
| title |
Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats. |
| title_short |
Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats. |
| title_full |
Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats. |
| title_fullStr |
Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats. |
| title_full_unstemmed |
Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats. |
| title_sort |
atrophic cardiac remodeling induced by taurine deficiency in wistar rats. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/adf7a0ecbccb41efafe7fc94daf9fbe5 |
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