Fluency shaping increases integration of the command-to-execution and the auditory-to-motor pathways in persistent developmental stuttering

Fluency-shaping enhances the speech fluency of persons who stutter, yet underlying conditions and neuroplasticity-related mechanisms are largely unknown. While speech production-related brain activity in stuttering is well studied, it is unclear whether therapy repairs networks of altered sensorimot...

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Autores principales:	Alexandra Korzeczek, Annika Primaßin, Alexander Wolff von Gudenberg, Peter Dechent, Walter Paulus, Martin Sommer, Nicole E. Neef
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Stuttering intervention Sensorimotor integration Neuroplasticity Inferior frontal gyrus Dorsal laryngeal motor cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/adfad624eea644ce8cd8260f48f8ee0d
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spelling	oai:doaj.org-article:adfad624eea644ce8cd8260f48f8ee0d2021-11-28T04:29:08ZFluency shaping increases integration of the command-to-execution and the auditory-to-motor pathways in persistent developmental stuttering1095-957210.1016/j.neuroimage.2021.118736https://doaj.org/article/adfad624eea644ce8cd8260f48f8ee0d2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921010089https://doaj.org/toc/1095-9572Fluency-shaping enhances the speech fluency of persons who stutter, yet underlying conditions and neuroplasticity-related mechanisms are largely unknown. While speech production-related brain activity in stuttering is well studied, it is unclear whether therapy repairs networks of altered sensorimotor integration, imprecise neural timing and sequencing, faulty error monitoring, or insufficient speech planning. Here, we tested the impact of one-year fluency-shaping therapy on resting-state fMRI connectivity within sets of brain regions subserving these speech functions. We analyzed resting-state data of 22 patients who participated in a fluency-shaping program, 18 patients not participating in therapy, and 28 fluent control participants, measured one year apart. Improved fluency was accompanied by an increased connectivity within the sensorimotor integration network. Specifically, two connections were strengthened; the left inferior frontal gyrus showed increased connectivity with the precentral gyrus at the representation of the left laryngeal motor cortex, and the left inferior frontal gyrus showed increased connectivity with the right superior temporal gyrus. Thus, therapy-associated neural remediation was based on a strengthened integration of the command-to-execution pathway together with an increased auditory-to-motor coupling. Since we investigated task-free brain activity, we assume that our findings are not biased to network activity involved in compensation but represent long-term focal neuroplasticity effects.Alexandra KorzeczekAnnika PrimaßinAlexander Wolff von GudenbergPeter DechentWalter PaulusMartin SommerNicole E. NeefElsevierarticleStuttering interventionSensorimotor integrationNeuroplasticityInferior frontal gyrusDorsal laryngeal motor cortexNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118736- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Stuttering intervention Sensorimotor integration Neuroplasticity Inferior frontal gyrus Dorsal laryngeal motor cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Stuttering intervention Sensorimotor integration Neuroplasticity Inferior frontal gyrus Dorsal laryngeal motor cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Alexandra Korzeczek Annika Primaßin Alexander Wolff von Gudenberg Peter Dechent Walter Paulus Martin Sommer Nicole E. Neef Fluency shaping increases integration of the command-to-execution and the auditory-to-motor pathways in persistent developmental stuttering
description	Fluency-shaping enhances the speech fluency of persons who stutter, yet underlying conditions and neuroplasticity-related mechanisms are largely unknown. While speech production-related brain activity in stuttering is well studied, it is unclear whether therapy repairs networks of altered sensorimotor integration, imprecise neural timing and sequencing, faulty error monitoring, or insufficient speech planning. Here, we tested the impact of one-year fluency-shaping therapy on resting-state fMRI connectivity within sets of brain regions subserving these speech functions. We analyzed resting-state data of 22 patients who participated in a fluency-shaping program, 18 patients not participating in therapy, and 28 fluent control participants, measured one year apart. Improved fluency was accompanied by an increased connectivity within the sensorimotor integration network. Specifically, two connections were strengthened; the left inferior frontal gyrus showed increased connectivity with the precentral gyrus at the representation of the left laryngeal motor cortex, and the left inferior frontal gyrus showed increased connectivity with the right superior temporal gyrus. Thus, therapy-associated neural remediation was based on a strengthened integration of the command-to-execution pathway together with an increased auditory-to-motor coupling. Since we investigated task-free brain activity, we assume that our findings are not biased to network activity involved in compensation but represent long-term focal neuroplasticity effects.
format	article
author	Alexandra Korzeczek Annika Primaßin Alexander Wolff von Gudenberg Peter Dechent Walter Paulus Martin Sommer Nicole E. Neef
author_facet	Alexandra Korzeczek Annika Primaßin Alexander Wolff von Gudenberg Peter Dechent Walter Paulus Martin Sommer Nicole E. Neef
author_sort	Alexandra Korzeczek
title	Fluency shaping increases integration of the command-to-execution and the auditory-to-motor pathways in persistent developmental stuttering
title_short	Fluency shaping increases integration of the command-to-execution and the auditory-to-motor pathways in persistent developmental stuttering
title_full	Fluency shaping increases integration of the command-to-execution and the auditory-to-motor pathways in persistent developmental stuttering
title_fullStr	Fluency shaping increases integration of the command-to-execution and the auditory-to-motor pathways in persistent developmental stuttering
title_full_unstemmed	Fluency shaping increases integration of the command-to-execution and the auditory-to-motor pathways in persistent developmental stuttering
title_sort	fluency shaping increases integration of the command-to-execution and the auditory-to-motor pathways in persistent developmental stuttering
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/adfad624eea644ce8cd8260f48f8ee0d
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Fluency shaping increases integration of the command-to-execution and the auditory-to-motor pathways in persistent developmental stuttering

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