Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow

Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow

Tumor cell in the peritoneum are often exposed to shear forces generated by ascitic flow during metastasis. Here, the authors show that metastatic cancer stem cells tether more and roll slower than the non-metastatic counterparts, and that sialyl-Lewisx -P-selectin axis mediates peritoneal metastasi...

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Autores principales: Shan-Shan Li, Carman K. M. Ip, Matthew Y. H. Tang, Maggie K. S. Tang, Yin Tong, Jiangwen Zhang, Ayon Ahmed Hassan, Abby S. C. Mak, Susan Yung, Tak-Mao Chan, Philip P. Ip, Cheuk Lun Lee, Philip C. N. Chiu, Leo Tsz On Lee, Hung-Cheng Lai, Jin-Zhang Zeng, Ho Cheung Shum, Alice S. T. Wong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/adfaf653b8994433a83662d8754dca91
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Sumario:Tumor cell in the peritoneum are often exposed to shear forces generated by ascitic flow during metastasis. Here, the authors show that metastatic cancer stem cells tether more and roll slower than the non-metastatic counterparts, and that sialyl-Lewisx -P-selectin axis mediates peritoneal metastasis.

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