Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow
Tumor cell in the peritoneum are often exposed to shear forces generated by ascitic flow during metastasis. Here, the authors show that metastatic cancer stem cells tether more and roll slower than the non-metastatic counterparts, and that sialyl-Lewisx -P-selectin axis mediates peritoneal metastasi...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/adfaf653b8994433a83662d8754dca91 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:adfaf653b8994433a83662d8754dca91 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:adfaf653b8994433a83662d8754dca912021-12-02T17:33:11ZSialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow10.1038/s41467-019-10334-62041-1723https://doaj.org/article/adfaf653b8994433a83662d8754dca912019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10334-6https://doaj.org/toc/2041-1723Tumor cell in the peritoneum are often exposed to shear forces generated by ascitic flow during metastasis. Here, the authors show that metastatic cancer stem cells tether more and roll slower than the non-metastatic counterparts, and that sialyl-Lewisx -P-selectin axis mediates peritoneal metastasis.Shan-Shan LiCarman K. M. IpMatthew Y. H. TangMaggie K. S. TangYin TongJiangwen ZhangAyon Ahmed HassanAbby S. C. MakSusan YungTak-Mao ChanPhilip P. IpCheuk Lun LeePhilip C. N. ChiuLeo Tsz On LeeHung-Cheng LaiJin-Zhang ZengHo Cheung ShumAlice S. T. WongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Shan-Shan Li Carman K. M. Ip Matthew Y. H. Tang Maggie K. S. Tang Yin Tong Jiangwen Zhang Ayon Ahmed Hassan Abby S. C. Mak Susan Yung Tak-Mao Chan Philip P. Ip Cheuk Lun Lee Philip C. N. Chiu Leo Tsz On Lee Hung-Cheng Lai Jin-Zhang Zeng Ho Cheung Shum Alice S. T. Wong Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow |
| description |
Tumor cell in the peritoneum are often exposed to shear forces generated by ascitic flow during metastasis. Here, the authors show that metastatic cancer stem cells tether more and roll slower than the non-metastatic counterparts, and that sialyl-Lewisx -P-selectin axis mediates peritoneal metastasis. |
| format |
article |
| author |
Shan-Shan Li Carman K. M. Ip Matthew Y. H. Tang Maggie K. S. Tang Yin Tong Jiangwen Zhang Ayon Ahmed Hassan Abby S. C. Mak Susan Yung Tak-Mao Chan Philip P. Ip Cheuk Lun Lee Philip C. N. Chiu Leo Tsz On Lee Hung-Cheng Lai Jin-Zhang Zeng Ho Cheung Shum Alice S. T. Wong |
| author_facet |
Shan-Shan Li Carman K. M. Ip Matthew Y. H. Tang Maggie K. S. Tang Yin Tong Jiangwen Zhang Ayon Ahmed Hassan Abby S. C. Mak Susan Yung Tak-Mao Chan Philip P. Ip Cheuk Lun Lee Philip C. N. Chiu Leo Tsz On Lee Hung-Cheng Lai Jin-Zhang Zeng Ho Cheung Shum Alice S. T. Wong |
| author_sort |
Shan-Shan Li |
| title |
Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow |
| title_short |
Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow |
| title_full |
Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow |
| title_fullStr |
Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow |
| title_full_unstemmed |
Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow |
| title_sort |
sialyl lewisx-p-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/adfaf653b8994433a83662d8754dca91 |
| work_keys_str_mv |
AT shanshanli sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT carmankmip sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT matthewyhtang sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT maggiekstang sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT yintong sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT jiangwenzhang sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT ayonahmedhassan sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT abbyscmak sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT susanyung sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT takmaochan sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT philippip sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT cheuklunlee sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT philipcnchiu sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT leotszonlee sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT hungchenglai sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT jinzhangzeng sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT hocheungshum sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow AT alicestwong sialyllewisxpselectincascademediatestumormesothelialadhesioninasciticfluidshearflow |
| _version_ |
1718380019659571200 |